个人简历

2017-至 今：中国科学院上海营养与健康研究所 研究员
2015-2016年：中国科学院上海生命科学研究院/上海交通大学医学院 健康科学研究所 研究员
2010-2015年：MD Anderson Cancer Center 博士后
2007-2010年：中国科学院上海生命科学研究院 博士
2006-2007年：中国科学院上海生命科学信息中心 编辑
2003-2006年：华东理工大学 硕士
1999-2003年：湖北大学 学士

研究领域

蛋白质的翻译后修饰（post-translational modifications, PTM），如磷酸化、泛素化、乙酰化等，在细胞信号转导过程中发挥重要调控作用。在免疫细胞中，特定的PTM修饰可通过影响信号蛋白分子的降解、蛋白-蛋白之间相互作用，蛋白转运等，进而调节免疫细胞的发育、存活和活化等。因此，发现并解析特定PTM在免疫细胞中的功能对于免疫相关疾病病理机制的认识，以及疾病的防治具有重要意义。我们主要聚焦PTM的动态调控作用，利用遗传突变小鼠及相应病理模型，结合临床病人样品，主要研究：
1. 免疫细胞活化及相关炎症与自身免疫性疾病中的调节功能与分子机制
2. 肿瘤病理过程中免疫学特征、分子机制与免疫干预策略
3. 中枢神经系统免疫调节及其炎症反应过程中的病理与分子机制""

近期论文

Zhang X, Wang Y, Yuan J, Li N, Pei S, Xu J, Luo X, Mao C, Liu J, Yu T, Gan S, Zheng Q, Liang Y, Guo W, Qiu J, Constantin G, Jin J, Qin J*, Xiao Y*. Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3. J Exp Med. 2018 May 7;215(5):1365-1382
Liu J, Huang X, Hao S, Wang Y, Liu M, Xu J, Zhang X, Yu T, Gan S, Dai D, Luo X, Lu Q, Mao C, Zhang Y, Shen N, Li B, Huang M, Zhu X, Jin J, Cheng X, Sun SC, Xiao Y*. Peli1 negatively regulate noncanonical NF-κB signaling to restrain systemic lupus erythematosus. Nat Commun. 2018;9:1136
Zheng T#, Xu C#, Mao C*, Mou X, Wu F, Wang X, Bu L, Zhou Y, Luo X, Lu Q, Liu H, Yuan G, Wang S, Chen D, Xiao Y*. Increased Interleukin-23 in Hashimoto's Thyroiditis Disease Induces Autophagy Suppression and Reactive Oxygen Species Accumulation. Front Immunol. 2018;9:96. (#Equal contribution)
Xu C, Wu F, Mao C*, Wang X, Zheng T, Bu L, Mou X, Zhou Y, Yuan G, Wang S, Xiao Y*. Excess iodine promotes apoptosis of thyroid follicular epithelial cells by inducing autophagy suppression and is associated with Hashimoto thyroiditis disease. J Autoimmun. 2016;75:50-57
Xiao Y, Jin J, Chang M, Chang JH, Hu H, Zhou X, Brittain GC, Stansberg C, Torkildsen ？, Wang X, Brink R, Cheng X, Sun SC. Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation. Nat Med, 2013;19:595-602 (News and Views in Nat Med. 2013;19:536-538. Research highlighted in Nat Immunol, 2013;14:535)
>Xiao Y, Jin J, Chang M, Nakaya M, Hu H, Zou Q, Zhou X, Brittain GC, Cheng X, Sun SC. TPL2 mediates autoimmune inflammation through activation of the TAK1 axis of IL-17 signaling. J Exp Med. 2014;211:1689-1702
Xiao Y#, Zou Q#, Xie X#, Liu T, Li HS, Jie Z, Jin J, Hu H, Manyam G, Zhang L, Cheng X, Wang H, Marie I, Levy DE, Watowich SS, Sun SC. The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity. J Exp Med. 2017;214:1493-1507 (# Equal contribution)
Liu Y, Peng J, Sun T, Li N, Zhang L, Ren J, Yuan H, Kan S, Pan Q, Li X, Ding Y, Jiang M, Cong X, Tan M, Ma Y, Fu D, Cai S, Xiao Y, Wang X, Qin J. Epithelial EZH2 serves as an epigenetic determinant in experimental colitis by inhibiting TNFα-mediated inflammation and apoptosis. Proc Natl Acad Sci U S A. 2017;114:E3796-E3805
Gao Z, Li Y, Wang F, Huang T, Fan K, Zhang Y, Zhong J, Cao Q, Chao T, Jia J, Yang S, Zhang L, Xiao Y, Zhou JY, Feng XH, Jin J. Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability. Nat Commun. 2017;8(1):1805.
Jin J, Xiao Y, Chang JH, Yu J, Hu H, Starr R, Brittain GC, Chang M, Cheng X, Sun SC. The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling. Nat Immunol. 2012;13:1101-1109.
Chang JH, Xiao Y, Hu H, Jin J, Yu J, Zhou X, Wu X, Johnson HM, Akira S, Pasparakis M, Cheng X, Sun SC. Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells. Nat Immunol. 2012;13:481-490.
Nakaya M, Xiao Y, Zhou X, Chang JH, Chang M, Cheng X, Blonska M, Lin X, Sun SC. Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation. Immunity. 2014;40:692-705
Jin J, Xiao Y, Hu H, Zou Q, Li Y, Cheng X, Sun SC. Proinflammatory TLR signaling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages. Nat Comm. 2015;6:5930.
Hu H, Wang H, Xiao Y, Jin J, Chang JH, Zou Q, Xie X, Cheng X, Sun SC. Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination. J Exp Med. 2016;213:399-414
Jin J, Xie X, Xiao Y, Hu H, Zou Q, Cheng X, Sun SC. Epigenetic regulation of the expression of Il12 and Il23 and autoimmune inflammation by the deubiquitinase Trabid. Nat Immunol. 2016;17:259-268
Romano S, Xiao Y, Nakaya M, D’Angelillo A, Chang M, Jin J, Felix Hausch4, Masullo M, Feng X, Romano MF, Sun SC. FKBP51 employs both scaffold and isomerase functions to promote NF-kB activation in melanoma. Nucleic Acids Res. 2015;43: 6983-6993
Chang M, Jin W, Chang JH, Xiao Y, Brittain GC, Yu J, Zhou X, Wang YH, Cheng X, Li P, Rabinovich BA, Hwu P, Sun SC. The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat Immunol. 2011;12:1002-1009.
Hu H, Brittain GC, Chang JH, Puebla-Osorio N, Jin J, Zal A, Xiao Y, Cheng X, Chang M, Fu YX, Zal T, Zhu C, Sun SC. OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3. Nature. 2013;494:371-374
Jin J, Hu H, Li HS, Yu J, Xiao Y, Brittain GC, Zou Q, Cheng X, Mallette FA, Watowich SS, Sun SC. Noncanonical NF-κB Pathway Controls the Production of Type I Interferons in Antiviral Innate Immunity. Immunity. 2014;40:342-354
Zou Q, Jin J, Hu H, Li HS, Romano S, Xiao Y, Nakaya M, Zhou Xi, Cheng X, Yang P, Lozano G, Zhu C, Watowich SS, Ullrich SE, Sun SC. USP15 stabilizes MDM2 to mediate cancer cell survival and inhibit antitumor T-cell responses. Nat Immunol. 2014;15:562-570
Zou Q, Jin J, Xiao Y, Hu H, Zhou X, Li J, Cheng X, Jie Z, Xie X. T cell development involves TRAF3IP3-mediated ERK signaling in the Golgi. J Exp Med. 2015;212:1323-1336
Zou Q, Jin J, Xiao Y, Zhou X, Hu H, Cheng X, Kazimi N, Ullrich SE, Sun SC. T Cell Intrinsic USP15 Deficiency Promotes Excessive IFN-γ Production and an Immunosuppressive Tumor Microenvironment in MCA-Induced Fibrosarcoma. Cell Rep. 2015;13:2470-2479
Chang JH, Hu H, Jin J, Puebla-Osorio N, Xiao Y, Blink R, Ullrich SE, Sun SC. TRAF3 regulates follicular regulatory T cell induction and humoral immune responses. J Exp Med. 2014;211:137-151
Yu J, Zhou X Chang M, Nakaya M, Chang J, Xiao Y, Lindsey JW, Dorta-Estremera S, Cao W, Zal A, Zal T, Sun SC. Regulation of T-cell migration by the kinase TBK1 during neuroinflammation. Nat Comm. 2015;6:6074.
Li HS, Liu C, Xiao Y, Chu F, Liang X, Peng W, Hu J, Neelapu SS, Sun SC, Hwu P, Watowich SS. Bypassing STAT3-mediated inhibition of the transcriptional regulator ID2 improves the antitumor efficacy of dendritic cells. Sci Signal. 2016;9: ra94
Xiao Y*, Sun SC*. TPL2 mediates IL-17R signaling in neuroinflammation. Oncotarget. 2015;6:21789-21790 (* Corresponding)
Xiao Y, Xu J, Mao C, Jin M, Wu Q, Zou J, Gu Q, Zhang Y, Zhang Y. 18β-glycyrrhetinic acid ameliorated Propionibacterium acnes-induced acute liver injury through inhibition of macrophage inflammatory protein-1α. J Biol Chem. 2010;285:1128-1137
Xiao Y#, Xu J#, Wang S, Mao C, Jin M, Ning G, Xu J, Zhang Y. Genetic ablation of steroid receptor coactivator-3 promotes PPAR-β-mediated alternative activation of microglia/macrophages in experimental autoimmune encephalomyelitis. Glia. 2010;58:932-942 (#Equal contribution)
Xiao Y, Zhang Y. Suppressor of cytokine signaling-1, a possible cause for regulatory T cells in hepatitis? Hepatology. 2008;48:1353.
Xiao Y, Jin J, Zou Q, Hu H, Cheng X, Sun SC. Peli1 negatively regulates type I interferon induction and antiviral immunity in the CNS. Cell & Bioscience. 2015;5:34.