个人简历

2017-至 今：中国科学院上海营养与健康研究所 研究员
2008-2016年：中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所 研究员
2008-2014年 中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所 所长
2003-2008年：美国新泽西医科和牙科大学-罗伯特伍德约翰逊医学院分子遗传学、微生物学和免疫学系 终身教授
2001-2008年：美国新泽西癌症研究所 研究员
2001-2003年：美国新泽西医科和牙科大学-罗伯特伍德约翰逊医学院分子遗传学、微生物学和免疫学系 终身副教授
1999-2001年：美国红十字协会Holland医学生物研究所免疫学部 终身副教授
1996-1999年：美国乔治华盛顿大学微生物学和免疫学系 助理教授、博士生导师
1995-1999年：美国红十字协会Holland医学生物研究所免疫学部Scientist I 助理教授
1992-1995年：加拿大多伦多大学免疫学系 博士后
1986-1989年：加拿大阿尔伯塔大学动物学系 助教
1982-1985年；山东农学院畜牧兽医系 助教

研究领域

干细胞、肿瘤、免疫、自身免疫性疾病
1. 间充质干细胞的免疫调节：间充质干细胞在组织修复中具有重要作用，而损伤组织与炎症反应密切相关。因此，了解间充质干细胞与免疫细胞之间的作用关系是必要的。我们已经发现，炎症因子赋予间充质干细胞免疫调节能力，并且这种免疫调节能力具有“可塑性”。我们的研究将系统阐明间充质干细胞与免疫之间的相互作用及机制，相关研究成果对于理解多种免疫性疾病的病理机制和探寻相关疾病的治疗新策略具有重要意义。
2. 肿瘤免疫调控：免疫监视是控制肿瘤发生发展的关键。随着研究的不断进展，免疫疗法成为继手术治疗、放化疗之外的肿瘤治疗的另一重要研究方向。虽然已有许多免疫疗法在肿瘤治疗过程中显示出一定的疗效，但却无一被证实能够治愈肿瘤。我们的研究重点将集中在肿瘤基质（即癌细胞生存的土壤）上，以其了解肿瘤微环境中免疫反应调控的具体机制。
3. 免疫细胞代谢调控：促炎和抑炎的免疫细胞具有不同的代谢偏好，研究表明胞内的代谢活动不仅为免疫细胞提供了能量，也决定了免疫细胞的功能。我们的研究旨在一方面解析代谢对免疫细胞的功能的调控机制，另一方面开发靶向免疫细胞代谢的新策略来治疗免疫失调性疾病。
4. 不同T细胞亚群的活化诱导细胞凋亡（AICD）过程及机制：T细胞受抗原刺激后会迅速增殖，并伴随细胞死亡。因此，了解不同T细胞群体的死亡机制对控制传染病、癌症和自身性免疫疾病具有重要意义。""

近期论文

Liu K, Lin L, Li Q, Xue Y, Zheng F, Wang G, Zheng C, Du L, Hu M, Shao C, Kong X, Melino G, Shi Y*, Wang Y*. Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II. Proc Natl Acad Sci U S A 2020 Feb 4;117(5):2462-2472.
Nicolai, Pieraccioli M, Smirnov A, Pitolli C, Anemona L, Mauriello A, Candi E, Annicchiarico-Petruzzelli M, Shi Y, Wang Y, Melino G., Raschella G. ZNF281/Zfp281 Is a Target of miR-1 and Counteracts Muscle Differentiation. Mol Oncol 2020 Feb;14(2):294-308.
Pitolli C, Wang Y, Mancini M, Shi Y, Melino G, Amelio I., Do Mutations Turn p53 Into an Oncogene? Int J Mol Sci 2019 Dec 11;20(24). pii: E6241.
Pitolli C, Wang Y, Mancini M, Shi Y, Candi E., Melino G, Amelio I.p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms. Cancers (Basel) 2019 Dec 9;11(12). pii: E1983.
Li XL, Liu R, Su X, Pan YS, Han XF*, Shao CS*, Shi Y*. Harnessing Tumor-Associated Macrophages as Aids for Cancer Immunotherapy. Mol Cancer 2019 Dec 5;18(1):177.
Lanna C, Mancini M, Gaziano R, Cannizzaro MV, Galluzzo M, Talamonti M, Rovella V, Annicchiarico-Petruzzelli M, Melino G, Wang Y, Shi Y, Campione E, Bianchi L. Skin immunity and its dysregulation in psoriasis. Cell Cycle 2019 Oct;18(20):2581-2589.
Jiang Y, Li C, Wu Q, An P, Huang L, Wang J, Chen C, Chen X, Zhang F, Ma L, Liu S, He H, Xie S, Sun Y, Liu H, Zhan Y, Tao Y, Liu Z, Sun X, Hu Y, Wang Q, Ye D, Zhang J, Zou S, Wang Y, Wei G, Liu Y, Shi Y, Eugene Chin Y, Hao Y, Wang F, Zhang X. Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses. Nat Commun 2019 Jul 3;10(1):2935.
Gong Z, Shang B, Chu Y, Chen X, Li Q, Liu K, Chen Y, Huang Y, Han Y, Shang Q, Zheng Z, Song L, Li Y, Liu R, Xu C, Zhang X, Liu B, Wang L*, Shao C*, Wang Y*, Shi Y*. Fibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development. Cell Death Dis 2019 Jun 5;10(6):440.
Huang Y, Li Q, Zhang K, Hu M, Wang Y, Du L, Lin L, Li S, Sorokin L, Melino G, Shi Y*, Wang Y*. Single cell transcriptomic analysis of human mesenchymal stem cells reveals limited heterogeneity. Cell Death Dis 2019 May 8;10(5):368.
Fibbe WE*, Shi Y*. FOXO3, a Molecular Search for the Fountain of Youth. Cell Stem Cell 2019 Mar 7;24(3):351-352.
Du L, Lin L, Li Q, Liu K, Huang Y, Wang X, Cao K, Chen X, Cao W, Li F, Shao C, Wang Y*, Shi Y*. IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties. Cell Metab 2019 Jun 4;29(6):1363-1375.e8.
Huang L, Xu C, Xu P, Qin Y, Chen M, Feng Q, Pan J, Cheng Q, Liang F, Wen X, Wang Y, Shi Y, Cheng Y. Intelligent Photosensitive Mesenchymal Stem Cells and Cell-Derived Microvesicles for Photothermal Therapy of Prostate Cancer. Nanotheranostics 2018 Nov 11;3(1):41-53.
Li X, Shang B, Li YN, Shi Y*, Shao C*. IFNγ and TNFα synergistically induceapoptosis of mesenchymal stem/stromal cells via the induction of nitric oxide. Stem Cell Res Ther 2019 Jan 11;10(1):18.
Yi S, Zhai J, Niu R, Zhu G, Wang M, Liu J, Huang H, Wang Y, Jing X, Kang L, Song W, Shi Y, Tang H. Eosinophil recruitment is dynamically regulated byinterplay among lung dendritic cell subsets after allergen challenge. Nat Commun 2018 Sep 24;9(1):3879.
Li X, Song W, Shao C, Shi Y*, Han W*. Emerging predictors of the response to the blockade of immune checkpoints in cancer therapy. Cell Mol Immunol 2019 Jan;16(1):28-39.
Shi Y*, Wang Y, Li Q, Liu K, Hou J, Shao C, Wang Y*. Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases. Nat Rev Nephrol 2018 Aug;14(8):493-507.
Chen Y, Liu K, Shi Y, Shao C. The tango of ROS and p53 in tissue stem cells. Cell Death Differ 2018 Mar;25(4):639-641.
Galluzzi L, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ 2018 Mar;25(3):486-541.
Wang G, Cao K, Liu K, Xue Y, Roberts AI, Li F, Han Y, Rabson AB, Wang Y*, Shi Y*. Kynurenic acid, an IDO metabolite, controls TSG-6-mediated immunosuppression of human mesenchymal stem cells. Cell Death Differ 2018 Jul;25(7):1209-1223.
Shi Y, Du LM, Lin LY, Wang Y. Tumor associated mesenchymal stem/stromal cells: emerging therapeutic targets. Nat Rev Drug Discov 2017 Jan;16(1):35-52.
Yu P, Huang Y, Xu C, Lin L, Han Y, Sun W, Hu G, Rabson A, Wang Y*, Shi Y*. Downregulation of CXCL12 in Mesenchymal Stromal Cells by TGFβ Promotes Breast Cancer Metastasis. Oncogene 2017 Feb 9;36(6):840-849.
Yu P, Huang Y, Han Y, Lin L, Rabson A, Wang Y*, Shi Y*. TNFα-activated Mesenchymal Stromal Cells Promote Breast Cancer Metastasis through Recruiting CXCR2+ Neutrophils. Oncogene 2017 Jan 26;36(4):482-490.
Lin L, Du L, Cao K, Huang Y, Yu P, Zhang L, Li F, Wang Y*, Shi Y*. Tumour cell-derived exosomes endow mesenchymal stromal cells with tumour-promotion capabilities. Oncogene 2016 Nov 17;35(46):6038-6042.
Shou P, Chen Q, Jiang J, Xu C, Zhang J, Zheng C, Jiang M, Velletri T, Cao W, Huang Y, Yang Q, Han X, Zhang L, Wei L, Rabson AB, Chin YE, Wang Y*, Shi Y*. Type I Interferons Exert Anti-tumor Effect via Reversing Immunosuppression Mediated by Mesenchymal Stromal Cells. Oncogene 2016 Nov 17;35(46):5953-5962.
Jiang M, Zheng C, Shou P, Li N, Cao G, Chen Q, Xu C, Du L, Yang Q, Cao J, Han Y, Li F, Cao W, Zhang L, Wang Y*, Shi Y*. SHP1 Regulates Bone Mass by Directing Mesenchymal Stem Cell Differentiation. Cell Rep 2016 Jul 19;16(3):769-780.
Chen Q, Shou P, Zheng C, Jiang M, Cao G, Yang Q, Cao J, Xie N, Velletri T, Zhang X, Xu C, Zhang L, Yang H, Hou J, Wang Y*, Shi Y*. Fate decision of mesenchymal stem cells: adipocytes or osteoblasts? Cell Death Differ 2016 Jul;23(7):1128-1139.
Zheng C, Yang Q, Cao J, Xie N, Liu K, Shou P, Qian F, Wang Y*, Shi Y*. Local proliferation initiates macrophage accumulation in adipose tissue during obesity. Cell Death Dis 2016 Mar 31;7:e2167.
Velletri T, Xie N, Wang Y, Huang Y, Yang Q, Chen X, Chen Q, Shou P, Gan Y, Cao G, Melino G, Shi Y*. P53 functional abnormality in mesenchymal stem cells promotes osteosarcoma development. Cell Death Dis 2016 Jan 21;7:e2015.
Galipeau J, Krampera M, Barrett J, Dazzi F, Deans RJ, DeBruijn J, Dominici M, Fibbe WE, Gee AP, Gimble JM, Hematti P, Koh MB, LeBlanc K, Martin I, McNiece IK, Mendicino M, Oh S, Ortiz L, Phinney DG, Planat V, Shi Y, Stroncek DF, Viswanathan S, Weiss DJ Sensebe L. International Society for Cellular Therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase clinical trials. Cytotherapy 2016 Feb;18(2):151-159.
Liu Y, Yang X, Jing Y, Zhang S, Zong C, Jiang J, Sun K, Li R, Gao L, Zhao X, Wu D, Shi Y, Han Z, Wei L. Contribution and Mobilization of Mesenchymal Stem Cells in a mouse model of carbon tetrachloride-induced liver fibrosis. Sci Rep 2015 Dec 8;5:17762.
Zhou Y, Wu K, Jiang J, Huang J, Zhang P, Zhu Y, Hu G, Lang J, Shi Y, Hu L, Huang T, Kong X. Integrative analysis reveals enhanced regulatory effects of human long intergenic non-coding RNAs in lung adenocarcinoma. J Genet Genomics 2015 Aug 20;42(8):423-436.
Zheng C, Yang Q, Xua C, Shou P, Cao J, Jiang M, Chen Q, Cao G, Han Y, Li F, Cao W, Zhang L, Zhang L, Shi Y*, Wang Y*. CD11b Regulates Obesity-Induced Insulin Resistance via Limiting Alternative Activation and Proliferation of Adipose Tissue Macrophages. Proc Natl Acad Sci U S A 2015 Dec 29;112(52):E7239-E7248.
Shi Y, Cao J, Wang Y. Rethinking regeneration: empowerment of stem cells by inflammation. Cell Death Differ 2015 Dec;22(12):1891-1892.
Cheng Y, Wang B, Zhou H, Dang S, Jin M, Shi Y, Hao L, Yang Z, Zhang Y. Autophagy is Required for the Maintenance of Liver Progenitor Cell Functionality. Cell Physiol Biochem 2015;36(3):1163-1174.
Liu Z, Cao W, Xu L, Chen X, Zhan Y, Yang Q, Liu S, Chen P, Jiang Y, Sun X, Tao Y, Hu Y, Li C, Wang Q, Wang Y, Chen CD*, Shi Y*, Zhang X*. The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation. J Mol Cell Biol 2015 Dec;7(6):505-516.
Cao K, Wang G, Li W, Zhang L, Wang R, Huang Y, Du L, Jiang J, Wu C, He X, Roberts AI, Li F, Rabson AB, Wang Y*, Shi Y*. Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity. Oncogene 2015 Dec 3;34(49):5960-5970.
Zhu K, Zhang N, Guo N, Yang J, Wang J, Yang C, Yang C, Zhu L, Xu C, Deng Q, Zhu R, Wang H, Chen X, Shi Y, Li Y*, Leng Q*. SSC(high)CD11b(high)Ly-6C(high)Ly-6G(low) myeloid cells curtail CD4 T cell response by inducible nitric oxide synthase in murine hepatitis. Int J Biochem Cell Biol 2014 Sep;54:89-97.
Cao W, Cao K, Cao J, Wang Y, Shi Y*. Mesenchymal stem cells and adaptive immune responses. Immunol Lett 2015 Dec;168(2):147-153.
Chen F, Zhuang X, Lin L, Yu P, Wang Y, Shi Y, Hu G, Sun Y. New horizons in tumor microenvironment biology: challenges and opportunities. BMC Med 2015 Mar 5;13:45. doi: 10.1186/s12916-015-0278-7.
Khan I, Zhang L, Mohammed M, Archer FE, Abukharmah J, Yuan Z, Rizvi SS, Melek MG, Rabson AB, Shi Y, Weinberger B, Vetrano AM. Effects of Wharton's jelly-derived mesenchymal stem cells on neonatal neutrophils. J Inflamm Res 2014 Dec 31;8:1-8.
Wang Y, Chen X, Cao W, Shi Y*. Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. Nat Immunol 2014 Nov;15(11):1009-1016.
Zhang M, Zhou H, Zheng C, Xiao J, Zuo E, Liu W, Xie D, Shi Y, Wu C, Wang H, Li D, Li J. The roles of testicular c-kit positive cells in de novo morphogenesis of testis. Sci Rep 2014 Aug 4;4:5936.
Yin S, Yang J, Lin B, Deng W, Zhang Y, Yi X, Shi Y, Tao Y, Cai J, Wu CI, Zhao G, Hurst LD, Zhang J, Hu L, Kong X. Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients. Sci Rep 2014 Aug 12;4:6036.
Shi Y*. The 1000th publication features protection of normal cells during chemotherapy: a land mark for Cell Death & Disease. Cell Death Dis 2014 Feb 13;5:e1062.
Han X, Yang Q, Lin L, Xu C, Zheng C, Chen X, Han Y, Li M, Cao W, Cao K, Chen Q, Xu G, Zhang Y, Zhang J, Schneider RJ, Qian Y, Wang Y*, Brewer G*, Shi Y*. Interleukin-17 enhances immunosuppression by mesenchymal stem cells. Cell Death Differ 2014 Nov;21(11):1758-1768.
Ma S, Xie N, Li W, Yuan B, Shi Y*, Wang Y*. Immunobiology of mesenchymal stem cells. Cell Death Differ 2014 Feb;21(2):216-225.
Zhang Y, Cai W, Huang Q, Gu Y, Shi Y, Huang J, Zhao F, Liu Q, Wei X, Jin M, Wu C, Xie Q, Zhang Y, Wan B, Zhang Y. Mesenchymal stem cells alleviate bacteria-induced liver injury in mice by inducing regulatory dendritic cells. Hepatology 2014 Feb;59(2):671-682.
Zhu K, Zhang N, Guo N, Yang J, Wang J, Yang C, Yang C, Zhu L, Xu C, Deng Q, Zhu R, Wang H, Chen X, Shi Y, Li Y, Leng Q. SSC(high)CD11b(high)Ly-6C(high)Ly-6G(low) myeloid cells curtail CD4 T cell response by inducible nitric oxide synthase in murine hepatitis. Int J Biochem Cell Biol 2014 Sep;54:89-97.
Yang X, Han Z, Zhang S, Zhu P, Hao C, Fan T, Yang Y, Li L, Shi Y*, Wei L*. Chronic restraint stress decreases the repair potential from mesenchymal stem cells on liver injury by inhibiting TGF-β1 generation. Cell Death Dis 2014 Jun 26;5:e1308.
Liu S, Sun X, Wang M, Hou Y, Zhan Y, Jiang Y, Liu Z, Cao X, Chen P, Liu Z, Chen X, Tao Y, Xu C, Mao J, Cheng C, Li C, Hu Y, Wang L, Chin YE, Shi Y,, Siebenlist U, Zhang X. A microRNA miR-221- and miR-222-mediated feedback loop, via PDLIM2, maintains constitutive activation of nuclear factor κB and STAT3 in colorectal cancer cells. Gastroenterology 2014 Oct;147(4):847-859.e11.
Ke F, Zhang L, Liu Z, Liu J, Yan S, Xu Z, Bai J, Zhu H, Lou F, Wang H, Shi Y, Jiang Y, Su B, Wang H. Autocrine IL-6 drives skin-derived mesenchymal stem cell trafficking via regulating voltage-gated Ca(2+) channels. Stem Cells 2014 Oct;32(10):2799-810.
Cao G, Yang Q, Zhang SY, Xu CL, Roberts, AI, Wang Y*, Shi Y*. Mesenchymal stem cells prevent restraint stress-induced lymphocyte depletion via interleukin-4. Brain Behav Immun 2014 May;38:125-132.
Chen X, Gan Y, Li W, Su J, Zhang Y, Huang Y, Roberts AI, Han Y, Li J, Wang Y, Shi Y*. The interaction between mesenchymal stem cells and steroids during inflammation. Cell Death Dis 2014 Jan 23;5:e1009.
Ling W, Zhang J, Yuan Z, Ren G, Zhang L, Chen X, Rabson AB, Roberts AI, Wang Y, Shi Y*. Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment. Cancer Res 2014 Mar 1;74(5):1576-87.
Song X, Gao H, Lin Y, Yao Y, Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, Qian Y. Alterations in the Microbiota Drive Interleukin-17C Production from Intestinal Epithelial Cells to Promote Tumorigenesis. Immunity 2014 Jan 16;40(1):140-152.
Xu C, Yu P, Han X, Du L, Gan J, Wang Y, Shi Y*. TGF-β Promotes Immune Responses in the Presence of Mesenchymal Stem Cells. J Immunol 2014 Jan 1;192(1):103-109.
Ren G, Liu Y, Zhao X, Zhang J, Zheng B, Yuag Z, Zhang L, Tischfield J, Shao C*, Shi Y*. Tumor resident mesenchymal stromal cells endow na？ve stromal cells with tumor-promoting properties. Oncogene 2014 Jul 24;33(30):4016-4020.
Huang Y, Yu P, Li W, Ren G, Roberts, AI, Cao W, Zhang X, Su J, Chen X, Chen Q, Shou P, Xu C, Du L, Lin L, Zhang L, Xie N, Wang Y*, Shi Y*. p53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation. Oncogene 2014 Jul 17;33(29):3830-8.
Su J, Chen X, Huang Y, Li W, Li J, Cao K, Cao G, Zhang L, Li F, Roberts AI, Kang H, Yu P, Ren G, Ji W, Wang Y*, Shi Y*. Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species. Cell Death Differ 2014 Mar;21(3):388-396.
Chen Q, Shou P, Zhang L, Xu C, Zheng C, Han Y, Li W, Huang Y, Zhang X, Shao C, Roberts AI, Rabson AB, Ren G, Zhang Y, Wang Y, Denhardt DT, Shi Y*. An Osteopontin-Integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells. Stem Cells 2014 Feb;32(2):327-337.
Hou J, Han Z, Jing Y, Yang X, Zhang S, Sun K, Hao C, Meng Y, Yu F, Liu X, Shi Y, Wu M, Zhang L, Wei LX. Autophagy prevents irradiation injury and maintains stemness through decreasing ROS generation in mesenchymal stem cells. Cell Death Dis 2013 Oct 10;4:e844.
Xu C, Lin L, Cao G, Chen Q, Shou P, Huang Y, Han Y, Wang Y*, Shi Y*. Interferon-α-secreting mesenchymal stem cells exert potent antitumor effect in vivo. Oncogene 2014 Oct 16;33(42):5047-5052.
Chen P, Zhang J, Zhan Y, Su J, Du Y, Xu G, Shi Y, Siebenlist U, Zhang X. Established thymic epithelial progenitor/stem cell-like cell lines differentiate into mature thymic epithelial cells and support T cell development. PLoS One 2013 Sep 23;8(9):e75222.
Zhang J, Liu C, Roberts AI, Xu G, REN G, Zhang L, Devadas S* and Shi Y*. A novel subset of helper T cells promotes immune responses by secreting GM-CSF. Cell Death Differ 2013 Dec;20(12):1731-41.
Wu Q, Wang H, Zhao X, Shi Y, Jin M, Wan B, Xu H, Cheng Y, Ge H, Zhang Y. Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor that induces angiogenesis and migration in human colorectal carcinoma. Oncogene 2013 Dec 5;32(49):5541-5550.
Yu B, He Z, You P, Han Q, Xiang D, Chen F, Wang M, Liu C, Lin X, Borjigin U, Zi X, Li J, Zhu H, Li W, Han C, Wangensteen KJ, Shi Y, Hui L, Wang X, Hu Y. Reprogramming fibroblasts into bipotential hepatic stem cells by defined factors. Cell Stem Cell 2013 Sep 5;13(3):328-340.
Liu B*, Chen X, Wang Y, Shi Y*. Curative effect of hepatic portal venous administration of autologous bone marrow in AIDS patients with decompensated liver cirrhosis. Cell Death Dis 2013 Jul 25;4:e739.
Phinney DG, Galipeau J, Krampera M, Martin I, Shi Y, Sensebe L. MSCs: science and trials. Nat Med 2013 Jul;19(7):812.
Wei X, Yang X, Han Z, Qu F, Shao L*, Shi Y*. Mesenchymal stem cells: a new trend for cell therapy. Acta Pharmacol Sin 2013 Jun;34(6):747-754.
Xu C, Ren G, Cao G, Chen Q, Shou P, Zheng C, Du L, Han X, Jiang M, Yang Q, Lin L, Wang G, Yu P, Zhang X, Cao W, Brewer G, Wang Y*, Shi Y*. MiR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding protein 2. J Biol Chem 2013 Apr 19;288(16):11074-11079.
Krampera M, Galipeau J, Shi Y, Tarte K, Sensebe L. MSC Committee of the International Society for Cellular Therapy (ISCT). Immunological characterization of multipotent mesenchymal stromal cells - The International Society for Cellular Therapy (ISCT) working proposal. Cytotherapy 2013 Sep;15(9):1054-1061.
Wu X, Chesoni S, Rondeau G, Tempesta C, Patel R, Charles S, Daginawala N, Zucconi BE, Kishor A, Xu G, Shi Y, Li ML, Barreto PI, Welsh J, Wilson GM, Brewer G. Combinatorial mRNA binding by AUF1 and Argonaute 2 controls decay of selected target mRNAs. Nucleic Acids Res 2013 Feb 1;41(4):2644-2658.
Yang X, Hou J, Han Z, Wang Y, Hao C, Wei L*, Shi Y*. One cell, multiple roles: contribution of mesenchymal stem cells to tumor development in tumor microenvironment. Cell Biosci 2013 Jan 21;3(1):5.
Liu Z, Jiang Y, Hou Y, Hu Y, Cao X, Tao Y, Xu C, Liu S, Wang S, Wang L, Shi Y, Siebenlist U, Zhang X. The IκB family member Bcl-3 stabilizes c-Myc in colorectal cancer. J Mol Cell Biol2013 Aug;5(4):280-2.
Zeng A, Li Y, Wang C, Han X, Li G, Wang JY, Li D, Qin Y, Shi Y, Brewer G, Jing Q. Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells. J Cell Biol 2013 Apr 29;201(3):409-25.
Lang JY, Shi Y, Chin YE. Reprogramming cancer cells: back to the future. Oncogene 2013 May 2;32(18):2247-2248.
Ren G, Zhao X, Wang Y, Zhang X, Chen X, Xu C, Yuan Z, Roberts A, Zhang L, Zheng B, Wen T, Han Y, Rabson A, Tischfield J, Shao C, Shi Y*. CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα. Cell Stem Cell2012 Dec 7;11(6):812-824.
Qu F, Gao H, Zhu S, Shi P, Zhang Y, Liu Y, Jallal B, Yao Y, Shi Y, Qian Y. TRAF6-dependent Act1 phosphorylation by the IκB kinase-related kinases suppresses interleukin-17-induced NF-κB activation. Mol Cell Biol 2012 Oct;32(19):3925-3937.
L'huillier A, Ren G, Shi Y*, Zhang J*. A two-hit model of autoimmunity: lymphopenia and unresponsiveness to TGF-β signaling. Cell Mol Immunol 2012 Sep;9(5):369-370.
Zhu S, Pan W, Song X, Liu Y, Shao X, Tang Y, Liang D, He D, Wang H, Liu W, Shi Y, Harley JB, Shen N, Qian Y. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Nat Med 2012 Jul;18(7):1077-1086.
Yao Y, Wang Y, Chen F, Huang Y, Zhu S, Leng Q, Wang H, Shi Y, Qian Y. NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens. Cell Res 2012 May;22(5):836-847.
Li W, Ren G, Huang Y, Su J, Han Y, Li J, Chen X, Cao K, Chen Q, Shou P, Zhang L, Yuan ZR, Roberts AI, Shi S, Le AD, Shi Y*. Mesenchymal stem cells: a double-edged sword in regulating immune responses. Cell Death Differ 2012 Sep;19(9):1505-1513.
Han Z, Jing Y, Zhang S, Liu Y, Shi Y*, Wei L*. The role of immunosuppression of mesenchymal stem cells in tissue repair and tumor growth. Cell Biosci 2012 Mar 5;2(1):8.
Shi Y*, Su J, Roberts AI, Shou P, Rabson AB, Ren G*. How mesenchymal stem cells interact with tissue immune responses. Trends Immunol 2012 Mar;33(3):136-143.
Sensebé L, Tarte K, Galipeau J, Krampera M, Martin I, Phinney DG, Shi Y. Limited Acquisition of Chromosomal Aberrations in Human Adult Mesenchymal Stromal Cells. Cell Stem Cell 2012 Jan 6;10(1):9-10; author reply 10-1. doi: 10.1016/j.stem.2011.12.005.
Shi Y*, Wei L, Wang Y, Ren G. Stem Cells Deployed for Bone Repair Hijacked by T Cells. Cell Stem Cell 2012 Jan 6;10(1):6-8.
Ren G, Chen X, Dong F, Li W, Ren X, Zhang Y, Shi Y*. Concise review: mesenchymal stem cells and translational medicine: emerging issues. Stem Cells Transl Med 2012 Jan;1(1):51-58.
Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, Dawson TM, Dawson VL, El-Deiry WS, Fulda S, Gottlieb E, Green DR, Hengartner MO, Kepp O, Knight RA, Kumar S, Lipton SA, Lu X, Madeo F, Malorni W, Mehlen P, Nunez G, Peter ME, Piacentini M, Rubinsztein DC, Shi Y, Simon HU, Vandenabeele P, White E, Yuan J, Zhivotovsky B, Melino G, Kroemer G. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 2012 Jan;19(1):107-120.
Han Z, Tian Z, Lv G, Zhang L, Jiang G, Sun K, Wang C, Bu X, Li R, Shi Y, Wu M, Wei L. Immunosuppressive effect of bone marrow‐derived mesenchymal stem cells in inflammatory microenvironment favours the growth of B16 melanoma cells. J Cell Mol Med 2011 Nov;15(11):2343-52. doi: 10.1111/j.1582-4934.2010.01215.x.
Shi P, Zhu S, Lin Y, Liu Y, Liu Y, Chen Zn, Shi Y, Qian Y. Persistent Stimulation with Interleukin-17 Desensitizes Cells Through SCFβ-TrCP-Mediated Degradation of Act1. Sci Signal 2011 Nov 1;4(197):ra73. doi: 10.1126/scisignal.2001653.
Song X, Zhu S, Shi P, Liu Y, Shi Y, Levin SD, Qian Y. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nat Immunol 2011 Oct 12;12(12):1151-8. doi: 10.1038/ni.2155.
Cao W, Yang Y, Wang Z, Liu A, Fang L, Wu F, Hong J, Shi Y, Leung S, Dong C, Zhang JZ. Leukemia Inhibitory Factor Inhibits T Helper 17 Cell Differentiation and Confers Treatment Effects of Neural Progenitor Cell Therapy in Autoimmune Disease. Immunity 2011 Aug 26;35(2):273-84. doi: 10.1016/j.immuni.2011.06.011.
Krause CD, Izotova LS, Ren G, Yuan ZR, Shi Y, Chen CC, Ron Y, Pestka S. Efficient co-expression of bicistronic proteins in mesenchymal stem cells by development and optimization of a multifunctional plasmid. Stem Cell Res Ther 2011 Mar 14;2(2):15. doi: 10.1186/scrt56.
Yamaza T, Ren G, Akiyama K, Chen C, Shi Y, Shi S. Mouse mandible contains distinctive mesenchymal stem cells. J Dent Res 2011 Mar;90(3):317-24. doi: 10.1177/0022034510387796.
Zhao F, Zhang Y, Wang H, Jin M, S, He S, Shi Y, Guo Y, Zhang Y. Blockade of osteopontin reduces alloreactive CD8+ T cell-mediated graft-versus-host disease. Blood 2011 Feb 3;117(5):1723-33. doi: 10.1182/blood-2010-04-281659.
Ren G, Roberts AI, Shi Y*. Adhesion molecules: key players in mesenchymal stem cell-mediated immunosuppression. Cell Adh Migr 2011 Jan-Feb;5(1):20-2. doi: 10.4161/cam.5.1.13491.
Hu G, Ren G, Shi Y*. The putative cannabinoid receptor GPR55 promotes cancer cell proliferation. Oncogene 2011 Jan 13;30(2):139-41. doi: 10.1038/onc.2010.502.
Zhu S, Pan W, Shi P, Gao H, Zhao F, Song X, Liu Y, Zhao L, Li X, Shi Y, Qian Y. Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling. J Exp Med 2010 Nov 22;207(12):2647-62. doi: 10.1084/jem.20100703.
Swaims AY, Khani F, Zhang Y, Roberts AI, Devadas S, Shi Y*, Rabson AB*. Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T cells. Blood 2010 Oct 21;116(16):2994-3003. doi: 10.1182/blood-2009-07-231050.
Arriola A, Kiel ME, Shi Y, McKinnon RD. Adjunctive MSCs enhance myelin formation by xenogenic oligodendrocyte precursors transplanted in the retina. Cell Res 2010 Jun;20(6):728-31. doi: 10.1038/cr.2010.63.
Shi Y*, Hu GZ, Su JJ, Li WZ, Chen Q, Shou PS, Xu CL, Chen XD, Huang Y, Zhu ZX, Huang X, Han XY, Xie NX, Ren GW. Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair. Cell Res 2010 May;20(5):510-8. doi: 10.1038/cr.2010.44.
Ye W, Gong X, Xie J, Wu J, Zhang X, Ouyang Q, Zhao X, Shi Y, Zhang X. AChE deficiency or inhibition decreases apoptosis and p53 expression and protects renal function after ischemia/reperfusion. Apoptosis 2010 Apr;15(4):474-87. doi: 10.1007/s10495-009-0438-3.
Yamaza T, Kentaro A, Chen C, Liu Y, Shi Y, Gronthos S, Wang S, Shi S. Immunomodulatory properties of stem cells from human exfoliated deciduous teeth. Stem Cell Res Ther 2010 Mar 15;1(1):5. doi: 10.1186/scrt5.
Ren GW, Zhao X, Zhang LY, Zhang JM, L'Huillier A, Ling WF, Roberts AI, Le AD, Shi ST, Shao CS, and Shi Y*. Inflammatory Cytokine-Induced Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 in Mesenchymal Stem Cells Are Critical for Immunosuppression. J Immunol 2010 Mar 1;184(5):2321-8. doi: 10.4049/jimmunol.0902023.
Markovina S, Callander NS, O′Connor SL, Xu G, Shi Y, Leith CP, Kim K, Trivedi P, Kim J, Hematti P, Miyamoto S. Bone marrow stromal cells from multiple myeloma patients uniquely induce bortezomib resistant NF-kappaB activity in myeloma cells. Mol Cancer 2010 Jul 6;9:176. doi: 10.1186/1476-4598-9-176.
Zhao X, Ren GW, Liang L, Zheng B, Tischfield JA, Shi Y*, Shao CS*. Brief report: IFN-γ induces expansion of Lin-Sca-1+C-Kit+ Cells. Stem Cells 2010 Jan;28(1):122-6. doi: 10.1002/stem.252.
Zhang Q, Shi S, Liu Y, Uyanne J, Shi Y, Shi S, Le AD. Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis. J Immunol 2009 Dec 15;183(12):7787-98. doi: 10.4049/jimmunol.0902318.
Das J, Ren GW, Zhang LY, Roberts IA, Zhao X, Bothwel ALM, Kaer LV, Shi Y*, Das G*. Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation. J Exp Med 2009 Oct 26;206(11):2407-16. doi: 10.1084/jem.20082286.
Izotova LS, Krause CD, Ren G, Yuan ZR, Shi Y, Pestka S. PP2-014 Visualizing engineered interferon-producing cells with multicistronic vectors and fluorescent proteins. Abstracts/Cytokine 2009, 48:91-137. Doi: 10.1016/j.cyto.2009.07.392.
Kong L, Sun L, Zhang H, Liu Q, Liu Y, Qin L, Shi G, Hu JH, Xu A, Sun YP, Li D, Shi Y, Zang JW, Zhu J, Chen Z, Wang ZG, Ge BX. An essential role for RIG-I in toll-like receptor-stimulated phagocytosis. Cell Host Microbe 2009 Aug 20;6(2):150-61. doi: 10.1016/j.chom.2009.06.008.
Ren G, Su J, Zhang L, Zhao X, Ling W, L′huillie A, Zhang J, Lu Y, Roberts AI, Ji W, Rabson AB, Shi Y*. Species Variation in the Mechanisms of Mesenchymal Stem Cell-Mediated Immunosuppression. Stem Cells 2009 Aug;27(8):1954-62. doi: 10.1002/stem.118.
Shi Y, Zhu J, Salomoni P, Tucci P, Lu X. A Sino-British frontier workshop of cancer biology. Cell Death Differ 2009 Apr;16(4):648-50. doi: 10.1038/cdd.2008.192.
Vavassori S, Shi Y, Chen CC, Ron Y, Covey LR. In vivo post-transcriptional regulation of CD154 in mouse CD4+ T cells. Eur J Immunol 2009 Aug;39(8):2224-32. doi: 10.1002/eji.200839163.
Xu G, Zhang Y, Zhang L, Roberts, A.I., Shi Y*. C/EBPβ Mdiates Synergistic Upregulation of Gene Expression by IFNγ and TNFα in Bone Marrow-Derived Mesenchymal Stem Cells. Stem Cells 2009 April;27(4):942–948. doi:10.1002/stem.22.
Wang KX, Shi Y, Ron Y, Kazanecki CC, Denhardt DT. Plasma osteopontin modulates chronic restraint stress-induced thymus atrophy by regulating stress hormones: inhibition by an anti-osteopontin monoclonal antibody. J Immunol 2009 Feb 15;182(4):2485-91. doi: 10.4049/jimmunol.0803023.
Qian Y, Shi Y*. Natural killer cells go inside: entosis versus cannibalism. Cell Res 2009 Dec;19(12):1320-1. doi: 10.1038/cr.2009.134.
Xu G, Zhang Y, Zhang L, Ren G, Shi Y*. Bone marrow stromal cells induce apoptosis of lymphoma cells in the presence of IFNgamma and TNF by producing nitric oxide. Biochem Biophys Res Commun 2008 Oct 31;375(4):666-70. doi: 10.1016/j.bbrc.2008.08.077.
Ren GW, Su JJ, Zhao X, Zhang LY, Zhang JM, Roberts AI, Zhang HT, Das G, Shi Y*. Apoptotic cells induce immunosuppression through dendritic cells: critical roles of IFN-gamma and nitric oxide. J Immunol 2008 Sep 1;181(5):3277-84. doi: 10.4049/jimmunol.181.5.3277.
Zhao RC, Zhu YS, Shi Y*. New Hope for Cancer Treatment: exploring the distinction between normal adult stem cells and cancer stem cells. Pharmacol Ther 2008 Jul;119(1):74-82. doi: 10.1016/j.pharmthera.2008.04.008.
Zhang YY, Xu GW, Zhang LY, Roberts AI, Shi Y*. Th17 Cells Undergo Fas-mediated Activation-induced Cell Independent of IFN-γ. J Immunol 2008 Jul 1;181(1):190-6. doi: 10.4049/jimmunol.181.1.190.
Yuan ZR and Shi Y*. Chloramphenicol induces abnormal differentiation and inhibits apoptosis in activated T cells. Cancer Res 2008 Jun 15;68(12):4875-81. doi: 10.1158/0008-5472.CAN-07-6061.
Zhang J, Jiang H, Gao W, Wu J, Peng K, Shi Y, Zhang X. The JNK/AP1/ATF2 pathway is involved in H2O2-induced acetylcholinesterase expression during apoptosis. Cell Mol Life Sci 2008 May;65(9):1435-45. doi: 10.1007/s00018-008-8047-9.
Shi Y* and August DA. A New Trick for an Old Drug: mTOR Inhibitor Rapamycin Augments the Effect of Fluorouracil on Hepatocellular Carcinoma through Inducing Cell Senescence. Cancer Biol Ther 2008 Mar;7(3):397-8. doi: 10.4161/cbt.7.3.5871.
Ren GW, Zhang LY, Zhao X, Xu GW, Zhang YY, Roberts AI, Zhao RC, Shi Y*. Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide. Cell Stem Cell 2008 Feb 7;2(2):141-50. doi: 10.1016/j.stem.2007.11.014.
Zhu H, Gao W, Jiang H, Jin QH, Shi Y, Tsim KW, Zhang XJ. Regulation of acetylcholinesterase expression by calcium signaling during calcium ionophore A23187- and thapsigargin-induced apoptosis. Int J Biochem Cell Biol 2007;39(1):93-108. doi: 10.1016/j.biocel.2006.06.012.
Zhu H, Gao W, Shi Y, Zhang XJ. The CCAAT-binding factor CBF/NF-Y regulates the human acetylcholinesterase promoter activity during calcium ionophore A23187-induced cell apoptosis. Biochim Biophys Acta 2007 Oct;1770(10):1475-82. doi: 10.1016/j.bbagen.2007.07.007.
Chen L, Zhang W, Yue H, Han Q, Chen B, Shi M, Li J, Li B, You S, Shi Y, Zhao RC. Effects of human mesenchymal stem cells on the differentiation of dendritic cells from CD34+ cells. Stem Cells Dev 2007 Oct;16(5):719-31. doi: 10.1089/scd.2007.0065.
Xu G, Zhang Y, Zhang L, Ren G, Shi Y*. The role of IL-6 in inhibition of lymphocyte apoptosis by mesenchymal stem cells. Biochem Biophys Res Commun 2007 Sep 28;361(3):745-50. doi: 10.1016/j.bbrc.2007.07.052.
Wang K, Desai B, Shi Y and Denhardt DT*. Osteopontin regulates hindlimb-unloading-induced lymphoid organ atrophy through modulating corticosteroid production. Proc Natl Acad Sci U S A 2007 Sep 11;104(37):14777-14782. doi: 10.1073/pnas.0703236104.
Ehirchiou D, Amarnath S, Xiong Y, Xu G, Chen W, Shi Y and Zhang L. CD11b Facilitates the Development of Peripheral Tolerance by Suppressing Th17 Differentiation. J Exp Med 2007 Jul 9;204(7):1519-1524. doi: 10.1084/jem.20062292.
Xu G and Shi Y*. Apoptosis signaling pathways and lymphocyte homeostasis. Cell Res 2007 Sep;17(9):759-771. doi: 10.1038/cr.2007.52.
Zhu H, Gao W, Jiang H, Wu J, Shi Y, Zhang X. Calcineurin mediates acetylcholinesterase expression during calcium ionophore A23187-induced HeLa cell apoptosis. Biochim Biophys Acta 2007 Apr;1773(4):593-602. doi: 10.1016/j.bbamcr.2007.01.008.
Xu G, Zhang L, Ren G, Yuan Z, Zhang Y, Zhao R, Shi Y*. Immunosuppressive properties of cloned bone marrow mesenchymal stem cells. Cell Res 2007 Mar;17(3):240-248. doi: 10.1038/cr.2007.4
Das J, Eynott P, Van Kaer L, Shi Y* and Das G. Natural killer T cells and CD8+ T cells are dispensable for T cell-dependent allergic airway inflammation. Nat Med 2006 Dec;12(12):1345-1346. doi: 10.1038/nm1206-1345.
Das G*, Mittal J, Zhang Y, Bothwell A, Van Kare Luc, and Shi Y*. Pivotal Roles of Major Histocompatibility Complex Class Ib Restricted CD8+ T Cells in Autoimmune Diseases. J Exp Med 2006 Nov 27;203(12):2603-11. doi: 10.1084/jem.20060936.
Devadas S, Das J, Liu C, Zhang L, Roberts AI, Pan Z, Moore PA, Das G, Shi Y*. Granzyme B is critical for T cell receptor-induced cell death of Type 2 helper T cells. Immunity 2006 Aug;25(2):237-247. doi: 10.1016/j.immuni.2006.06.011.
Shi Y, Roberts AI, Sun E. Dying T lymphocytes call for the death of tumor cells. Commentary. Cell Res 2006 Aug;16(8):679-680. doi: 10.1038/sj.cr.7310087.
Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C, Shi Y, Gelinas C, Fan Y, Nelson DA, Jin S, White E. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 2006 Jul;10(1):51-64. doi: 10.1016/j.ccr.2006.06.001
Devadas S, Liu C, Shi Y. Novel helper T cell subset helps other T cells through producing GM-CSF. The Journal of Immunology 2006;176:S14-S15.
Shi Y, Liu CH, Roberts AI, Das J, Xu G, Ren G, Zhang Y, Zhang L, Yuan ZR, Tan HS, Das G, Devadas S. Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) and T-Cell Responses: What We Do and Don′t Know. Cell Res 2006 Feb;16(2):126-133. doi: 10.1038/sj.cr.7310017.
Yuan ZR, Wang R, Solomon J, Luo X, Sun H, Zhang L, Shi Y. Identification and characterization of survival-related gene, a novel cell survival gene controlling apoptosis and tumorigenesis. Cancer Res 2005 Dec 1;65(23):10716-10724. doi:10.1158/0008-5472.CAN-05-2176.
Greeneltch KM, Kelly-Welch AE, Keegan AD*,Shi Y*. Chronic morphine treatment promotes specific Th2 cytokine production by murine T cells in vitro via a Fas/Fas