个人简历

2017-至 今：中国科学院上海营养与健康研究所，研究员，院长助理
2009-2016年：中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所，研究员
2014-2016年：中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所，副所长
2011-2014年：中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所，所长助理
2009-2009年：美国普林斯顿大学分子生物系，Associate Research Scholar
2005-2008年：美国普林斯顿大学分子生物系，博士后
2000-2005年：美国罗格斯大学，分子遗传学，博士
1996-2000年：清华大学，生物科学与技术系，学士

研究领域

肿瘤转移与微环境调控
1. 转移的微环境调控机制。肿瘤转移是癌症致死的主要原因。癌细胞对其所处微环境的适应及改造对转移过程有重要影响。我们主要研究癌细胞与转移微环境的互作机制，以及这些互作对肿瘤转移能力、转移的器官特异性、癌细胞的转移休眠/重激活状态的调控作用，并进一步发现有效预测肿瘤转移的分子标志物以及靶向肿瘤-微环境互作的策略。
2. 肿瘤干细胞与转移。肿瘤干细胞一般被认为是癌症发生、抗药及复发的“元凶”，但是肿瘤干细胞与转移的关系尚不清楚。我们主要研究肿瘤干细胞在转移中发挥的作用及调控机制，分析肿瘤干细胞的异质性，不同干细胞亚群的转移及调控，肿瘤干细胞与转移微环境的互作等，以期发现通过靶向肿瘤干细胞抑制转移的方法。
3. 肿瘤代谢调控与转移。肿瘤的Warburg效应已经引起广泛关注。我们主要研究在转移过程中的糖脂代谢调控，包括癌细胞自身的代谢异常模式、代谢微环境对癌细胞转移能力以及转移器官特异性的调控作用等。""

近期论文

Zhang P, Liu Y, Lian C, Cao X, Wang Y, Li X, Cong M, Tian P, Zhang X, Wei G, Liu T*, Hu G*. SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation. Nat Commun, 2020 May 19;11(1):2487
Cong M, Wang Y, Yang Y, Lian C, Zhuang X, Li X, Zhang P, Liu Y, Tang J, Yang Q, Zhang X, Xiong H*, Hu R*, Hu G*. MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination. Nat Cancer, 2020 Jan 20;1(2):222–234
Zhuang X, Zhang H, Li X, Li X, Cong M, Peng F, Yu J, Zhang X, Yang Q*, Hu G*. Differential effects on lung and bone metastasis of breast cancer by Wntsignalling inhibitor DKK1. Nat Cell Biol, 2017;19(10):1274-1285
Huang H, Zhang W, Pan Y, Gao Y, Deng L, Li F, Li F, Ma X, Hou S, Xu J, Li P, Li X, Hu G, Li C, Chen H, Zhang L, Ji H*. YAP suppresses lung squamous cell carcinoma progression via deregulation of the DNp63-GPX2 axis and ROS accumulation. Cancer Res, 2017 Nov 1;77(21):5769-5781
Hu J#, Li G#, Zhang P, Zhuang X, Hu G*. A CD44v+ subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity. Cell Death Dis, 2017;8(3):e2679
Li N, Xue W, Yuan H, Dong B, Ding Y, Liu Y, Jiang M, Kan S, Sun T, Ren J, Pan Q, Li X, Zhang P, Hu G, Wang Y, Wang X, Li Q, Qin J*. AKT-mediated stabilization of WHSC1 promotes prostate cancer metastasis. J Clin Invest, 2017;127(4):1284-1302
Li G, Li M, Hu J, Lei R, Xiong H, Ji H, Yin H, Wei Q*, Hu G*. The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis. Oncogene, 2017;36(7):989-998
Yu PF, Huang Y, Xu CL, Lin LY, Han YY, Sun WH, Hu G, Rabson AB, Wang Y, Shi Y*. Downregulation of CXCL12 in mesenchymal stromal cells by TGFβ promotes breast cancer metastasis. Oncogene, 2017;36(6):840-849
Yu J#, Lei R#, Zhuang X, Li X, Li G, Lev S, Segura MF, Zhang X, Hu G*. MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells. Nat Commun, 2016;7:13884
Chen X, Cao X, Sun X, Lei, Chen P, Zhao Y, Jiang Y, Yin J, Chen R, Ye D, Wang Q, Liu Z, Liu S, Cheng C, Mao J, HouY, Wang M, SiebenlistUt, Chin E, Wang Y, Cao L, Hu G*, Zhang X*. Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis. Cell Death Dis, 2016;7(12):e2508
Liang Y#, Hu J#, Li J, Liu Y, Yu J, Zhuang X, Mu L, Kong X, Hong D, Yang Q, Hu G*. Epigenetic activation of TWIST1 by MTDH promotes cancer stem-like Cell traits in breast cancer. Cancer Res, 2015;75:3672
Chen F, Zhuang X, Lin L, Yu P, Wang Y, Shi Y, Hu G, Sun Y*. New horizons in tumor microenvironment biology: challenges and opportunities. BMC Medicine, 2015;13:45
Wei Q，Lei R, Hu G*. Roles of miR-182 in sensory organ development and cancer. Thorac Cancer, 2015;6;2-9
Wan L, Hu G, Wei Y, Yuan M, Bronson RT, Yang Q, Siddiqui J, Pienta KJ, Kang Y*. Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis. Cancer Res, 2014;74(18):5336-5347
Lin B#, Wang Y#, Wang Z, Tan H, Kong X, Shu Y, Zhang Y, Huang Y, Zhu Y, Xu H, Wang Z, Wang P, Ning G, Kong X*, Hu G*, Hu L*. Uncovering the rare variants of DLC1 isoform 1 and their functional effects in a Chinese sporadic congenital heart disease cohort. PLoS One, 2014 Feb 28;9(2):e90215
WangY, Lei R, Zhuang X, Zhang N, Pan H, Li G, Hu J, Pan X, Tao Q, Fu D, Xiao J, Chin E, Kang Y, Yang Q*, Hu G*. DLC1-dependent parathyroid hormone-like hormone inhibition suppresses breast cancer bone metastasis. J Clin Invest, 2014;124(4):1646-1659
Zhang N, Wang X, Huo Q, Sun M, Cai C, Liu Z, Hu G, Yang Q*. MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin. Oncogene, 2014;33(24):3119-3128
Lei R#，Tang J#, Zhuang X, Deng R, Li G, Yu J, Liang Y, Xiao J, Wang H-Y, Yang Q, Hu G*. Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis. Oncogene, 2014 Mar 6;33(10):1287-1296
Zhang N, Wang X, Huo Q, Li X, Wang H-Y, Schneider P, Hu G*, Yang Q*. The oncogene metadherin modulates the apoptotic pathway based on thetumor necrosis factor superfamily member TRAIL in breast cancer. J Biol Chem, 2013;288(13):9396-9407
Liang Y, Wu H, Lei R, Chong RA, Wei Y, Lu X, Tagkopoulos I, Kung S-Y, Yang Q, Hu G*, Kang Y*. Transcriptional network analysis identifies BACH1 as amaster regulator of breast cancer bone metastasis. J Biol Chem, 2012;287(40):33533-33544
Jin L#, Zhang Y#, Li H, Yao L, Fu D, Yao X, Xu L*, Hu X*, Hu G*. Differential secretomeanalysis reveals CST6 as a suppressor of breast cancer bone metastasis. Cell Res, 2012;22(9):1356-1373
Yu X, Wang F, Liu H, Adams G, Aikhionbare F, Liu D, Cao X, Fan L, Hu G, Chen Y, Frost A, Partridge E, Ding X, Yao X*. ACAP4 cooperates with GRB2 to orchestrate EGF-stimulated integrin beta1 recycling in cell migration. J Biol Chem, 2011;286(51):43735-43747
Liang Y, Fu D, Hu G*. MTDH: An emerging key regulator of malignant progression in multiple cancers. Thorac Cancer, 2011;2:143-148
Korpal M, Ell B, Buffa F, Khan Z, Blanco M, Hua Y, Wei Y, Hu G, Garcia B, Ragoussis J, Singh M, Harris A, Kang Y*. Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med, 2011;17(9):1101-1108
Shan J#, Budijono S#, Hu G#, Yao N, Kang Y, Ju Y*, Prud’homme R*. PEGylated composite nanoparticles containing upconverting phosphors and meso-tetraphenylporphine (TPP) for photodynamic therapy. Adv Funct Mater, 2011 May 5;21(13):2488-2495
Lu X, Yan C, Yuan M, Wei Y, Hu G, Kang Y*. In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropicmetastasis of breast cancer. Cancer Res, 2010;70(10):3905-3914