个人简历

2020-Present: Professor and Principal investigator
Institut Pasteur Shanghai - Chinese Academy of SciencesInstitut Pasteur Shanghai - Chinese Academy of Sciences , Center for Microbes, Development and Health Shanghai, China
2014-2019: Senior Post-doctoral Fellow
Institut Pasteur Paris - INSERM Unit of Molecular Microbial Pathogenesis Paris, France
2010-2014: Post-doctoral Fellow
University of California Berkeley David Drubin Lab Berkeley, USA
2006-2010: Ph.D
Institut Pasteur - University Paris-Saclay (Paris 11) Institut Pasteur - University Paris-Saclay (Paris 11) Unit of Biology of Cell interactions Paris, France
2006 M.S
University Paris Descartes (Paris 5) Paris, France

研究领域

Our laboratory is exploring the complexity of the interactions happening at epithelial interfaces between microbes, host cells and microenvironment. In particular, we seek to elucidate how these events are dynamically integrated at the gut interface to function as a defensive barrier against pathogen infections.
A first aspect of our research aims at understanding the spatio-temporal organization of gut microbial communities to gain new insights into the protective role of gut microbiota against pathogens, such as Shigella flexneri. A second aspect of our research aim at understanding how tissue microarchitecture and mechanical forces play a role in the maintenance of the intestinal microbial ecosystem and how these physical cues impact host-pathogen interactions.
To pursue these goals, we are applying cutting edge strategies in stem cell bioengineering, genome-engineering, microfluidics and microfabrication to build ex vivo human mimetic organs (organ on chip). The high physiological relevance of these microfluidic models allow us to better model infectious processes and open new avenues for personalized medicine and drug discoveries.""

近期论文

1. Grassart A#, Valérie Malardé, Gobaa S, Anna Sartori-Rupp, Jordan Kerns, Katia Karalis, Benoit Marteyn, Sansonetti P and Sauvonnet N#. Cell Host & Microbe (2019) Sep 11;26(3):435-444. Bioengineered human organ-on-Chip reveals intestinal microenvironment and mechanical forces impacting Shigella infection.
# Corresponding authors
2. Ferrari M, Malardé V, Grassart A, Salavessa L, Nigro G, Decorps-Leclere S, Masson V, Arras G, Loew D, Rhode J, Sansonetti Pj, Sauvonnet N. Shigella flexneri induces a global blockage in host cell intracellular transport leading to cell and tissue disorganization. PNAS. (2019) Jul 2; 116(27):13582-13591.
3. Bertot L*, Grassart A*, Lagache T*, Nardi G*, Basquin C, Olivo-Marin JC and Sauvonnet N. Cell reports (2018) Feb 6;(22):1574-1588. Quantitative imaging and statistical analysis of the dynamics of clathrin-dependent and -independent endocytosis reveal a differential role of endophilinA2 in dynamin2 recruitment.
*These authors contributed equally to this work
4. Lagache T, Grassart A, Faklaris O, Sauvonnet N, Danglot L, Olivo-Marin JC. SODA: A statistical framework to analyze the spatial organization of molecules in multi-color super-resolution microscopy. Nature Communications (2018) Feb 15 ;9(1):698.
5. Grassart A*, Cheng AT*, Sun Hae Hong, Fan Zhang, Nathan Zenzer, Yongmei Feng, David M. Briner, Gregory D. Davis, Dmitry Malkov, Drubin DG. Actin and dynamin2 dynamics and interplay during clathrin mediated endocytosis. J Cell Biol. (2014) Jun 205 (5):721-735.
*These authors contributed equally to this work