个人简历

中山大学中山医学院教授、博士生导师、国家优秀青年科学基金获得者。2002年毕业于山东大学获得医学学士学位；2009年毕业于中科院上海生命科学研究院/上海交通大学医学院健康科学研究所师从上海交通大学医学院陈国强院士获得生物化学与分子生物学博士，2010年起在美国Stowers Institute for Medical Research从事博士后研究，师从著名华人干细胞专家Linheng Li教授；在中山大学任职至今。

研究领域

主要从事造血干细胞骨髓微环境以及骨髓间充质干细胞的基础转化研究

近期论文

Qian, P., De Kumar, B., He, X. C., Nolte, C., Gogol, M., Ahn, Y., Chen, S., Li, Z., Xu, H., Perry, J. M., Hu, D., Tao, F., Zhao, M., Han, Y., Hall, K., Peak, A., Paulson, A., Zhao, C., Venkatraman, A., Box, A., Perera, A., Haug, J. S., Parmely, T., Li, H., Krumlauf, R., and Li, L. (2018) Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis. Cell Stem Cell 22, 740-754 e747（影响因子22.39） Kang, X., Cui, C., Wang, C., Wu, G., Chen, H., Lu, Z., Chen, X., Wang, L., Huang, J., Geng, H., Zhao, M., Chen, Z., Muschen, M., Wang, H. Y., and Zhang, C. C. (2018) CAMKs support development of acute myeloid leukemia. J Hematol Oncol 11, 30（影响因子6.3） Jiang, L., Han, X., Wang, J., Wang, C., Sun, X., Xie, J., Wu, G., Phan, H., Liu, Z., Zhang, C.*, Zhao, M.*, and Kang, X*. (2018) SHP-1 regulates hematopoietic stem cell quiescence by coordinating TGF-beta signaling. The Journal of experimental medicine （*通讯作者，影响因子12） Qin W, Zheng Y, Qian BZ*, Zhao M*. Prostate cancer stem cells and nanotechnology: A focus on wnt signaling. Frontiers in pharmacology, 2017, 8: 153. （*通讯作者，影响因子4.8） Wang J, Zheng Y, Zhao M*. Exosome-Based Cancer Therapy: Implication for Targeting Cancer Stem Cells. Frontiers in pharmacology. 2016;7:533. （*通讯作者，影响因子4.8） Zhao, M., Li, L. (2016) Dissecting the bone marrow hematopoietic stem cell niches. Cell Res. 26: 975-976（影响因子14.82） Qian, P., He, X. C., Paulson, A., Li, Z., Tao, F., Perry, J. M., Guo, F., Zhao, M., Zhi, L., Venkatraman, A., Haug, J. S., Parmely, T., Li, H., Dobrowsky, R. T., Ding, W. X., Kono, T., Ferguson-Smith, A. C., Li, L. 2016 The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism. Cell stem cell 18, 214-228. （影响因子22.39） Zhao, M., Li, L. 2015 Regulation of hematopoietic stem cells in the niche. Science China Life Sciences 58, 1209-1215. （影响因子2.30） Zhao, M., Li, L. 2015. Osteoblast ablation burns out functional stem cells. Blood. 2015;125(17):2590-2591. （影响因子11.84） Zhao, M., Perry, J.M., Marshall, H., Venkatraman, A., Qian, P., He, X.C., Ahamed, J., and Li, L. 2014. Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells. Nat Med 20, 1321-1326. (Cover article). Featured in: Day, R. B. & Link, D. C. 2014 Megakaryocytes in the hematopoietic stem cell niche. Nat Med 20, 1233-1234. （影响因子30.36） Venkatraman, A., He, X.C., Thorvaldsen, J.L., Sugimura, R., Perry, J.M., Tao, F., Zhao, M., Christenson, M.K., Sanchez, R., Yu, J.Y., et al. 2013. Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence. Nature 500:345-349. （影响因子38.12） Zhao, M., Ross, J.T., Itkin, T., Perry, J.M., Venkatraman, A., Haug, J.S., Hembree, M.J., Deng, C.X., Lapidot, T., He, X.C., et al. 2012. FGF signaling facilitates postinjury recovery of mouse hematopoietic system. Blood 120:1831-1842. （影响因子11.84） Xia, L., Wang, T.D., Shen, S.M., Zhao, M., Sun, H., He, Y., Xie, L., Wu, Z.X., Han, S.F., Wang, L.S., et al. 2013. Phosphoproteomics study on the activated PKCdelta-induced cell death. J Proteome Res 12:4280-4301. （影响因子4.17） Wu, Z.X., Zhao, M. (co-first author), Xia, L., Yu, Y., Shen, S.M., Han, S.F., Li, H., Wang, T.D., Chen, G.Q., and Wang, L.S. 2013. PKCdelta enhances C/EBPalpha degradation via inducing its phosphorylation and cytoplasmic translocation. Biochem Biophys Res Commun 433:220-225. （影响因子2.37） Zhao, M., Xia, L., and Chen, G.Q. 2012. Protein kinase cdelta in apoptosis: a brief overview. Arch Immunol Ther Exp (Warsz) 60:361-372. （影响因子2.46） Zhao, X.Y., Zhao, K.W., Jiang, Y., Zhao, M., and Chen, G.Q. 2011. Synergistic induction of galectin-1 by CCAAT/enhancer binding protein alpha and hypoxia-inducible factor 1alpha and its role in differentiation of acute myeloid leukemic cells. J Biol Chem 286:36808-36819. （影响因子4.26） Gu, Z.M., Liu, C.X., Wu, S.F., Zhao, M., Xu, H.Z., Liu, W., Zhou, H.C., Chen, G.Q., and Wu, Y.L. 2011. PU.1 directly regulates retinoic acid-induced expression of RIG-G in leukemia cells. FEBS Lett 585:375-380. （影响因子3.52） Duan, X.F., Wu, Y.L., Xu, H.Z., Zhao, M., Zhuang, H.Y., Wang, X.D., Yan, H., and Chen, G.Q. 2010. Synergistic mitosis-arresting effects of arsenic trioxide and paclitaxel on human malignant lymphocytes. Chem Biol Interact 183:222-230. （影响因子2.62） Zhao, M., Duan, X.F., Zhao, X.Y., Zhang, B., Lu, Y., Liu, W., Cheng, J.K., and Chen, G.Q. 2009. Protein kinase Cdelta stimulates proteasome-dependent degradation of C/EBPalpha during apoptosis induction of leukemic cells. PLoS One 4:e6552. （影响因子3.06） Zhao, M., Duan, X.F., Wen, D.H., and Chen, G.Q. 2009. PU.1, a novel caspase-3 substrate, partially contributes to chemotherapeutic agents-induced apoptosis in leukemic cells. Biochem Biophys Res Commun 382:508-513. （影响因子2.37）