个人简历

周倜，女，中山大学中山医学院生物化学教研室副教授。2006年获得中山大学中山医学院临床医学学士学位，2011获得中山大学生物化学专业博士学位。2008年至2011年攻博期间在美国university of Oklahoma糖尿病研究中心从事“糖尿病并发症的分子机制”方面的研究工作，侧重研究经典Wnt信号通路在糖尿病并发症的病理作用及分子机制以及基因工程靶向治疗的研究。作为主要成员参与美国National Institutes of Health多项科研项目。2013年师资博士后出站留校工作至今，荣获“中山大学优秀博士后”、“2013年度中山大学青年教师英文授课比赛优秀奖”等奖励。

研究领域

研究方向为糖尿病血管并发症、代谢与肿瘤

近期论文

1）Zhou T, Hu Y, Chen Y, Zhou KK, Zhang B, Gao G, Ma JX. The pathogenic role of the canonical Wnt pathway in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4371-9（IF:3.5） 2）Zhou T, Zhou KK, Lee K, Gao G, Lyons TJ, Kowluru R, Ma J. The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy. Diabetologia. 2011 Feb;54(2):459-68.（IF:6.9） 3）Zhou T, He X, Cheng R, Zhang B, Zhang RR, Chen Y, Takahashi Y, Murray AR, Lee K, Gao G, Ma JX. Implication of dysregulation of the canonical wingless-type MMTV integration site (WNT) pathway in diabetic nephropathy. Diabetologia. 2012 Jan;55(1):255-66.（IF:6.9） 4）Dai Z*, Zhou T*, Li C, Qi W, Mao Y, Lu J, Yao Y, Li L, Zhang T, Hong H, Li S, Cai W, Yang Z, Ma J, Yang X, Gao G. Intracellular pigment epithelium-derived factor contributes to triglyceride degradation. Int J Biochem Cell Biol. 2013 Sep;45(9):2076-86. (IF 4.2) 5）Li S*, Zhou T*, Li C, Dai Z, Che D, Yao Y, Li L, Ma J, Yang X, Gao G. High metastatic gastric and breast cancer cells consume oleic acid in an AMPK dependent manner. PLoS One. 2014 May 13;9(5):e97330. (IF 3.5) 6）Hong H*, Zhou T*, Fang S*, Jia M, Xu Z, Dai Z, Li C, Li S, Li L, Zhang T, Qi W, Bardeesi AS, Yang Z, Cai W, Yang X, Gao G. Pigment epithelium-derived factor (PEDF) inhibits breast cancer metastasis by down-regulating fibronectin. Breast Cancer Res Treat. 2014 Nov;148(1):61-72. doi: 10.1007/s10549-014-3154-9. Epub 2014 Oct 5. (IF 4.1) 7）Che D*, Zhou T*, Lan Y, Xie J, Gong H, Li C, Feng J, Hong H, Qi W, Ma C, Wu Q, Yang X*, Gao G*. High glucose-induced epithelial-mesenchymal transition contributes to the upregulation of fibrogenic factors in retinal pigment epithelial cells. Int J Mol Med. 2016, Dec;38(6):1815-1822. （IF:2.3） 8）Zhou T*, Che D*, Lan Y1, Fang Z, Xie J, Gong H, Li C, Feng J, Hong H, Qi W, Ma C, Yang Z, Cai W, Zhong J, Ma J, Yang X, Gao G. Mesenchymal marker expression is elevated in Müller cells exposed to high glucose and in animal models of diabetic retinopathy. Oncotarget. 2017 Jan 17;8(3):4582-4594. （IF:5.0） 9）Chen Y, Hu Y, Zhou T, Zhou KK, Mott R, Wu M, Boulton M, Lyons TJ, Gao G, Ma JX. Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models. Am J Pathol. 2009 Dec;175(6):2676-2685. （IF:5.6） 10）Park K, Lee K, Zhang B, Zhou T, He X, Gao G, Murray AR, Ma JX. Identification of a Novel Inhibitor of the Canonical Wnt Pathway. Mol Cell Biol. 2011 Jul;31(14):3038-51（IF: 6.0） 11）Zhang B, Abreu JG, Zhou K, Chen Y, Hu Y, Zhou T, He X, Ma JX. Blocking the wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase family Proc Natl Acad Sci. 2010 Apr 13;107(15):6900-6905.（IF:9.4） 12）Li C, Li L, Cheng R, Dai Z, Li C, Yao Y, Zhou T, Yang Z, Gao G, Yang X. Acidic/neutral amino acid residues substitution in NH2 terminal of plasminogen kringle 5 exerts enhanced effects on corneal neovascularization. Cornea. 2013 May;32(5):680-8.（IF:9.4） 13）Dai Z, Qi W, Li C, Lu J, Mao Y, Yao Y, Li L, Zhang T, Hong H, Li S, Zhou T, Yang Z, Yang X, Gao G, Cai W. Dual regulation of adipose triglyceride lipase by pigment epithelium-derived factor: A novel mechanistic insight into progressive obesity. Mol Cell Endocrinol. 2013 Sep 5; 377(1-2):123-34. (IF 4.1) 14）Dai Z, Chen Y, Qi W, Huang L, Zhang Y, Zhou T, Yang X, Gao G.Codon optimization increases human kallistatin expression in Escherichia coli. Prep Biochem Biotechnol. 2013;43(1):123-36.（IF:0.7） 15）Yao Y, Li L, Huang X, Gu X, Xu Z, Zhang Y, Huang L, Li S, Dai Z, Li C, Zhou T, Cai W, Yang Z, Gao G, Yang X.SERPINA3K induces apoptosis in human colorectal cancer cells via activating the Fas/FasL/caspase-8 signaling pathway. FEBS J. 2013 Jul;280(14):3244-55.（IF:3.9） 16）Li L, Yao YC, Gu XQ, Che D, Ma CQ, Dai ZY, Li C, Zhou T, Cai WB, Yang ZH, Yang X, Gao GQ.Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop.J Biol Chem. 2014 Oct 8. pii: jbc.M114.567792. [Epub ahead of print]（IF:4.6） 17）Li L, Yao YC, Fang SH, Ma CQ, Cen Y, Xu ZM, Dai ZY, Li C, Li S, Zhang T, Hong HH, Qi WW, Zhou T, Li CY, Yang X, Gao GQ. Pigment Epithelial-derived Factor (PEDF)-triggered Lung Cancer Cell Apoptosis Relies on p53 Protein-driven Fas Ligand (Fas-L) Up-regulation and Fas Protein Cell Surface Translocation.J Biol Chem. 2014 Oct 31;289(44):30785-99. （IF:4.6） 18）Qi W, Yang C, Dai Z, Che D, Feng J, Mao Y, Cheng R, Wang Z, He X, Zhou T, Gu X, Yan L, Yang X, Ma JX, Gao G..High Levels of Pigment Epithelium-derived Factor in Diabetes Impair Wound Healing through Suppression of Wnt Signaling. Diabetes. 2014 Nov 3. pii: DB_141111. [Epub ahead of print]（IF:8.4） 19) Li S, Mao Y, Zhou T, Luo C, Xie J, Qi W, Yang Z, Ma J, Gao G, Yang X. Manganese superoxide dismutase mediates anoikis resistance and tumor metastasis in nasopharyngeal carcinoma. Oncotarget. 2016 Apr 13. doi: 10.18632/oncotarget.8717. [Epub ahead of print]（IF:5.0） 20) Liang ZW, Wang Z, Chen H, Li C, Zhou T, Yang Z, Yang X, Yang Y, Gao G, Cai W. Nestin-mediated cytoskeletal remodeling in endothelial cells: novel mechanistic insight into VEGF-induced cell migration in angiogenesis. Am J Physiol Cell Physiol. 2015 Mar 1;308(5):C349-58. （IF:3.4）