个人简历

袁岩，男，1982年毕业于山东大学生物系，1985年于中国科学院上海细胞生物学研究所获硕士学位，1991年于美国贝勒医学院获博士学位，1991年至1996年于美国耶鲁大学师从Sidney Altman教授（1989年诺贝尔奖获得者）从事博士后研究工作，1997年起，在美国宾夕法尼亚大学口腔医学院微生物系先后任助理教授、副教授和正教授。2010年12月任中山大学医学院人类病毒研究所教授、博导。

研究领域

从事病毒分子生物学研究十多年，在宾夕法尼亚大学任教期间率领一个具有国际领先水平的KSHV病毒学研究团队，其研究成果在以下几个病毒学领域中处于国际权威或领先地位：1. 世界上首次发现多个KSHV的即早基因（immediate-early genes）并研究了其相关的功能；2. 系统的研究KSHV对宿主抗病毒机理，尤其是对干扰素抗病毒作用的反制和逃匿；3. KSHV DNA复制的研究及抗病毒药物的筛选；4. KSHV病毒颗粒的结构、组装和成熟。

近期论文

1.Wang, Y., Sathish, N., Hollow, C. and Yuan, Y. (2011) Functional Characterization of Kaposi's Sarcoma-Associated Herpesvirus ORF K8 by Bacterial Artificial Chromosome-Based Mutagenesis. J. Virol. 85: 1943-1957. 2.Sathish, N., Zhu, F. X., Golub, E. E., Liang, Q. and Yuan, Y. (2011) Mechanisms of auto-inhibition of IRF-7 and a probable model for inactivation of IRF-7 by Kaposi′s Sarcoma-associated herpesvirus protein ORF45. J. Biol. Chem. 286: 746-756. 3.Zhu, F.X., Sathish, N. and Yuan, Y. (2010) Antagonism of Host Antiviral Responses by Kaposi's Sarcoma-associated Herpesvirus Tegument Protein ORF45. PLoSONE 5(5): e10573. 4.Sathish, N., Zhu, F.X. and Yuan, Y. (2009) Kaposi’s Sarcoma-associated Herpesvirus ORF45 Interacts with Kinesin-2 Transporting Viral Capsid-Tegument Complexes along Microtubules. PLoS Pathogens5(3): e1000332. 5.Rozen, R., Sathish, N., Li, Y. and Yuan, Y. (2008) Virion-wide protein interactions of Kaposi’s sarcoma-associated herpesvirus. J. Virol. 82: 4742-4750. 6.Wang, Y., Li, H., Hollow, C. and Yuan, Y. (2008) Kaposi’s Sarcoma-associated Herpesvirus ori-Lyt-dependent DNA Replication: Involvement of Cellular Factors in the Replication. J. Virol. 82: 2867-2882. 7.Zhu, F. X., Chong, J. M., Wu, L. and Yuan, Y. (2005) Virion Proteins of Kaposi’s Sarcoma-associated Herpesvirus. J. Virol. 79:800-811. 8.Wang, Y., Li, H., Chan, M. Y., Lukac, D. M. and Yuan, Y. (2004) Kaposi’s Sarcoma-Associated Herpesvirus ori-Lyt-dependent DNA Replication: cis-acting Requirements for the Replication and ori-Lyt-associated RNA Transcription. J. Virol. 78: 8615-8629. 9.Lin, C., Li, H., Wang, Y, Kudchodkar, S., Zhu, F. X. and Yuan, Y. (2003) Kaposi’s sarcoma-associated herpesvirus ori-Lyt-dependent DNA replication: Identification of the ori-Lyt and association of K8 bZip protein with the origin. J. Virol.77: 5578-5588. 10. Zhu, F. X., King, S. M., Smith, E. J., Levy, D. E. and Yuan, Y. (2002) A Kaposi’s sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation. Proc. Natl. Acad. Sci. USA 99: 5573-5578.