个人简历

杨霞，女，中山大学中山医学院生物化学教研室教授，博士生导师。中国医学生物化学与分子生物学青年委员会委员、中国生物化学与分子生物学会教学专业委员会第一届青年委员会委员、中国生物化学与分子生物学会脂质与脂蛋白专业委员会青年委员会委员、广东省生物化学学会副秘书长、广东省抗癌协会肿瘤转移专业委员会第一届委员会委员、广东省中西医结合学会实验医学专业委员会第二届委员会会员。1993年获得四川大学生物化学学士学位，1996年获得华西医科大学生物化学与分子生物学硕士学位，2006年获得中山大学生物化学与分子生物学博士学位。2011年1月晋升为教授和博士生导师。

研究领域

致力于K5、PEDF、KBP等血管抑制因子对恶性肿瘤的治疗作用、结构基础和分子机制研究。

近期论文

1. Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop. 所有作者：Li L, Yao YC, Gu XQ, Che D, Ma CQ, Dai ZY, Li C, Zhou T, Cai WB, Yang ZH, Yang X*(co-corresponding author), Gao GQ*. 发表杂志：J Biol Chem. 2014 Oct 8. pii: jbc.M114.567792. 发表年份：2014 2. Pigment epithelium-derived factor (PEDF) inhibits breast cancer metastasis by down-regulating fibronectin. 所有作者：Hong H, Zhou T, Fang S, Jia M, Dai Z, Li C, Li S, Zhang T, Qi W, Yang Z, Cai W, Yang X*(co-corresponding author), Gao G*. 发表杂志：Breast Cancer Res Treat. 2014 Nov;148(1):61-72. doi: 10.1007/s10549-014-3154-9. Epub 2014 Oct 5. 发表年份：2014 3. Pigment epithelial-derived factor(PEDF)-triggered lung cancer cell apoptosis relies on a p53-driven Fas-L up-regulation and Fas cell surface translocation. 所有作者：Li L, Yao YC, Fang SH, Ma CQ, Cen Y, Xu ZM, Dai ZY, Li C, Li S, Zhang T, Hong HH, Qi WW, Zhou T, Li CY, Yang X*(co-corresponding author), Gao GQ* 发表杂志：J Biol Chem. 2014 Sep 15. pii: jbc.M114.590000. 发表年份：2014 4. Anthraquinone G503 Induces Apoptosis in Gastric Cancer Cells through the Mitochondrial Pathway. 所有作者：Huang L, Zhang T, Li S, Duan J, Ye F, Li H, She Z, Gao G, Xia Yang* (Corresponding author). 发表杂志：PLoS One. 2014 Sep 30;9(9):e108286. doi: 10.1371/journal.pone.0108286. eCollection 2014. 发表年份：2014 5. High Metastaticgastric and Breast Cancer Cells Consume Oleic Acid in an AMPK Dependent Manner. 所有作者：Li S, Zhou T, Li C, Dai Z, Che D, Yao Y, Li L, Ma J, Yang X * (co-corresponding author), Gao G*. 发表杂志： PLoS One. 2014 May 13; 9(5):e97330. doi: 10.1371/journal. pone.0097330. eCollection 2014. 发表年份：2014 6. SERPINA3K induces apoptosis in human colorectal cancer cells via activating the Fas/FasL/caspase-8 signaling pathway. 所有作者：Yachao Yao, Lei Li, Xuan Huang, Xiaoqiong Gu, Zumin Xu, Yang Zhang, Lijun Huang, Shuai Li, Zhiyu Dai, Cen Li, Ti Zhou, Weibin Cai, ZhonghanYang, Guoquan Gao, Xia Yang* (Corresponding author). 发表杂志：FEBS Journal, 2013 Jul;280(14):3244-55. 发表年份：2013 7. Acidic/neutral amino acid residues substitution in NH2 terminal of Plasminogen kringle5 exerts enhanced effects on corneal neovascularization. 所有作者：Cen Li, Lei Li, Rui Cheng, Zhiyu Dai, Chaoyang Li, Yachao Yao, Ti Zhou, Zhonghan Yang, Guoquan Gao, Xia Yang* (Corresponding author). 发表杂志：Cornea. 2013 May:32(5):680-8. 发表年份：2013 8. Intracellular pigment epithelium-derived factor contributes to triglyceride degradation. 所有作者：Dai Z, Zhou T, Li C, Qi W, Mao Y, Lu J, Yao Y, Li L, Zhang T, Hong H, Li S, Cai W, Yang Z, Ma J, Yang X * (co-corresponding author), Gao G. 发表杂志：Int J Biochem Cell Biol. 2013 Sep;45(9):2076-86. 发表年份：2013 9. Kallikrein-binding protein inhibits LPS-induced TNF-α by upregulating SOCS3 expression. 所有作者：Zhiyu Dai, Lei Lu, ZhonghanYang, Cen Li, Weiwei Qi, Yifei Chen, Yuling Mao, Juling Lu, Yachao Yao, Lei Li, Shaobo Chen, Yang Zhang, Weibin Cai, Xia Yang* (co-corresponding author) and Guoquan Gao. 发表杂志：J Cell Biochem. 2013 May;114(5):1020-8. 发表年份：2013 10. Artemisinin derivative inhibits corneal neovascularization via inducing ROS-dependent endothelial cell apoptosis. Invest Ophthalmol Vis Sci. 2013 May 15;54(5):3400-9. 所有作者：Rui Cheng, Chen Li, Chaoyang Li, Ling Wei, Yang Zhang, Fang Ye, Yachao Yao, Xiaoqiong Gu, Weibin Cai, ZhonghanYang, Xia Yang* (co-corresponding author) and Guoquan Gao. 发表杂志：Invest Ophthalmol Vis Sci. 2013 May 15;54(5):3400-9. 发表年份：2013 11. Codon optimization increases human Kallistatin expression in Escherichia coli. 所有作者：Zhiyu Dai, Yifei Chen, Weiwei Qi, Lijun Huang, Yang Zhang, Ti Zhou, Rui Cheng, Xia Yang* (co-corresponding author) and Guoquan Gao 发表杂志：Preparative Biochemistry & Biotechnology, 2013;43(1):123-36. doi: 10.1080/10826068.2012.712079. 发表年份：2013 12. Decreased K5 receptor expression in the retina, a potential pathogenic mechanism for diabetic retinopathy. 所有作者：Jianfang Ma, Chaoyang Li, Chunkui Shao, Guoquan Gao , Xia Yang* (Corresponding author). 发表杂志：Molecular Vision 2012; 18:330-336. 发表年份：2012 13. Combination of PEDF with radiotherapy enhances the antitumor effects on nasopharyngeal carcinoma by down-regulating VEGF expression and angiogenesis. 所有作者：Zuming Xu, Shuhuan Fang, Yufang Zuo, Yang Zhang, Rui Cheng, Qingsong Wang, Zhonghan Yang, Weibin Cai, Jianxing Ma, Xia Yang* (Co-corresponding author), Guoquan Gao. 发表杂志：Cancer Sci. 2011 Oct;102(10):1789-98. 发表年份：2011 14. Plasminogen K5 activates mitochondrial apoptosis pathway of endothelial cells by regulating Bak and Bcl-xL subcellular translocation. Apoptosis, 2011. 16:846–855. 所有作者：Xiaoqiong Gu，Yachao Yao，Rui Cheng, Yang Zhang, Zhiyu Dai, Genping Wan, ZhonghanYang，Weibin Cai，Guoquan Gao, Xia Yang* (Corresponding author). 发表杂志：Apoptosis. 2011 Aug;16(8):846-55. 发表年份：2011 15. Inhibitory effect of small interfering RNA on dengue virus replication in mosquito cells. 所有作者：Xinwei Wu, Hua Hong, Jinya Yue, Yejian Wu, Xiangzhong Li, Liyun Jiang, Lei Li, Qiaoyan Li, Guoquan Gao, Xia Yang* (Corresponding author). 发表杂志：Virology Journal. 2010 Oct 14. 7:210. 发表年份：2010 16. Growth suppression of cervical carcinoma by pigment epithelium-derived factor via anti-angiogenesis. 所有作者：Jun Yang, Shuqin Chen, Xuan Huang, Jiande Han, Qingsong Wang, Dingbo Shi, Rui Cheng, Guoquan Gao, and Xia Yang* (Corresponding author). 发表杂志：Cancer Biol Ther. 2010 Jun 15;9(12):967-74. 发表年份：2010 17. High efficacy and minimal peptide required for the anti-angiogenic and anti-hepatocarcinoma activities of plasminogen K5. 所有作者：Xia Yang，Weibin Cai，Zumin Xu，Jing Chen，Chaoyang Li，Shaojun Liu, ZhonghanYang， Qiuhui Pan，Mingtao Li，Jianxing Ma，Guoquan Gao. 发表杂志：J Cell Mol Med. 2010 Oct 14(10): 2519–2530 发表年份：2010 18. PEDF inhibits growth of retinoblastoma by anti-angiogenic activity. 所有作者：Huasheng Yang，Rui Cheng, Guoying Liu, Qinghua Zhong, Chaoyang Li，Weibin Cai，ZhonghanYang， Jianxing Ma， Xia Yang* (Co-corresponding author), Guoquan Gao. 发表杂志：Cancer Science. 100(12):2419-2425, 2009 Dec 发表年份：2009 19. Kringle 5 of human plasminogen suppresses hepatocellular carcinoma growth both in grafted and xenografted mice by anti-angiogenic activity. 所有作者：Xia Yang, Rui Cheng, Chaoyang Li, Weibin Cai, Jian-xing Ma, Qianping Liu, Zhonghan Yang, Zhihong Song, Zuguo Liu, and Guoquan Gao 发表杂志：Cancer Biology & Therapy,2006 Apr; 5(4):399-405 发表年份：2006 20. Expression and Identification for Functional Epitope of Pigment Epithelium-derived Factor with Anti-angiogenic Activity.