个人简历
1993.9 – 1997.6 华中农业大学，水产养殖学士 1999.9 – 2004.6 华中农业大学，动物遗传育种博士 2004.7 – 2008.6 中山大学生命科学学院，讲师 2008至今 中山大学生命科学学院，副教授 2009.12–2010.11 美国Medical College of Georgia (现Georgia Health Sciences University)访问学者
研究领域
肿瘤相关基因的表达调控；非编码基因在肝癌发生发展中的作用及机制。
近期论文
Wang R, Fu T, You K, Li S, Zhao N, Yang J*, Zhuang SM*, Identification of a TGF-β-miR-195 positive feedback loop in hepatocytes and its deregulation in hepatoma cells. Faseb J, 2018, in press, PMID: 29465312. (IF= 5.5) You K, Li SY, Gong J, Fang JH, Zhang C, Zhang M, Yuan Y, Yang J*, Zhuang SM*. MicroRNA-125b promotes hepatic stellate cell activation and liver fibrosis by activating RhoA signaling. Mol Ther-Nucl Acids, 2018, 12: 57-66. (IF=6.4). Yang J, Lu Y, Lin YY, Zheng ZY, Fang JH, He S, Zhuang SM. Vascular mimicry formation is promoted by paracrine TGF-beta and SDF1 of cancer-associated fibroblasts and inhibited by miR-101 in hepatocellular carcinoma. Cancer Lett 2016;383:18-27. （IF= 6.4） Zhao N, Li S, Wang R, Xiao M, Meng Y, Zeng C, Fang JH, Yang J*, Zhuang SM*. Expression of microRNA-195 is transactivated by Sp1 but inhibited by histone deacetylase 3 in hepatocellular carcinoma cells. BBA- Gene Regul Mech 2016;1859: 933-42. （IF= 5.0） Liu JJ, Lin XJ, Yang X, Zhou L, He S, Zhuang SM*, Yang J*. A novel AP-1/miR-101 regulatory feedback loop and its implication in the migration and invasion of hepatoma cells. Nucleic Acids Res 2014, 42(19):12041-51. (IF= 10.2) Ge YY, Shi Q, Zheng ZY, Gong J, Zeng C, Yang J, Zhuang SM*. MicroRNA-100 promotes the autophagy of hepatocellular carcinoma cells by inhibiting the expression of mTOR and IGF-1R. Oncotarget 2014, 5(15):6218-28. (IF= 5.2) Zhou HC, Fang JH, Luo X, Zhang L, Yang J, Zhang C, Zhuang SM*. Downregulation of microRNA-100 enhances the ICMT-Rac1 signaling and promotes metastasis of hepatocellular carcinoma cells. Oncotarget 2014, 5(23):12177-88. (IF= 5.2) Yang J, Hu X, Zimmerman M, Torres CM, Yang D, Smith SB, Liu K. Cutting Edge: IRF8 Regulates Bax Transcription In Vivo in Primary Myeloid Cells. J Immunol 2011,187:4426-30. （IF= 4.9） Fang JH, Zhou HC, Zeng C, Yang J, Liu Y, Huang X, Zhang JP, et al. MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression. Hepatology 2011,54:1729-40. （IF= 13.2） Hu X, Yang D, Zimmerman M, Liu F, Yang J, Kannan S, Burchert A, et al. IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia. Cancer Res 2011,71:2882-91. （IF= 9.1） Zhao J, Yu BY, Wang DY, Yang JE*. Promoter polymorphism of MRP1 associated with reduced survival in hepatocellular carcinoma. World J Gastroenterol 2010,16:6104-10. (IF= 3.4) Xiong Y, Fang JH, Yun JP, Yang J, Zhang Y, Jia WH, Zhuang SM. Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma. Hepatology,51:836-45. （IF= 13.2） Luo J, Yang J, Yu BY, Liu W, Li M, Zhuang SM. Identification of Siah-interacting protein as a potential regulator of apoptosis and curcumin resistance. Oncogene 2010,29:6357-66. （IF= 7.5） Yang J, Zhou F, Xu T, Deng H, Ge YY, Zhang C, Li J, et al. Analysis of sequence variations in 59 microRNAs in hepatocellular carcinomas. Mutat Res 2008,638:205-9. （IF= 1.8） Huo DH, Yi LN, Yang J*. Interaction with Ppil3 leads to the cytoplasmic localization of Apoptin in tumor cells. Biochem Bioph Res Co 2008,372:14-8. (IF= 2.5) Cheng J, Huo DH, Kuang DM, Yang J, Zheng L, Zhuang SM. Human macrophages promote the motility and invasiveness of osteopontin-knockdown tumor cells. Cancer Res 2007,67:5141-7. （IF= 9.1） Hu LL, Wang XX, Chen X, Chang J, Li C, Zhang Y, Yang J, et al. BCRP gene polymorphisms are associated with susceptibility and survival of diffuse large B-cell lymphoma. Carcinogenesis 2007,28:1740-4. （IF= 5.1）
