个人简历

工作经历： 1998-2000年，北京大学，博士后 2000-2005年，美国加州大学洛杉矶分校医学院Cedars-Sinai 医学中心，博士后； 2005-2011年，美国加州大学洛杉矶分校医学院Cedars-Sinai 医学中心，研究员/助教授 2011-2011年，美国加州大学洛杉矶分校医学院Cedars-Sinai 医学中心，副教授 2011年--至今，中山大学孙逸仙纪念医院医学研究中心主任，研究员 现任中山大学孙逸仙纪念医院医学研究中心主任，广东省恶性肿瘤表观遗传与基因调控重点实验室专职副主任。2000-2011曾作为博士后、助教授和副教授在美国加州大学洛杉矶分校医学院（UCLA）Cedars-Sinai医学中心学习和工作。多年来一直从事分子肿瘤学研究，先后在Nature Genetics、PNAS、Hepatology、Cancer Research、Clinical Cancer Research、Leukemia、Oncogene、Oncotarget、Molecular Cancer Research、International Journal of Cancer等国际知名的肿瘤学学术期刊上发表SCI研究论文50余篇，其中20多篇第一作者和/或通信作者论文。担任国际杂志《Case Report in Oncological Medicine》编委。

研究领域

1. 肿瘤功能基因组学和肿瘤分子遗传学研究：利用肿瘤全基因组芯片和测序技术，扫描筛选癌症相关基因，研究其表达调控机制和肿瘤学功能及在诊断治疗中的应用。 2. CCN家族蛋白的肿瘤学功能与机制研究：揭示CCN家族蛋白作为分泌蛋白，在肿瘤中的功能和细胞生物学的作用机制。研究CCN蛋白作为细胞内蛋白，与肿瘤有丝分裂和抗药性的关系。该研究获得国自然国际合作类重点项目的资助。 3. 抗肿瘤小分子药物机理研究：阐明小分子抗肿瘤药物细胞生物学机制。研究组蛋白去乙酰化抑制剂、蛋白酶体抑制剂、激酶抑制剂和中药提取物等小分子药物的抗肿瘤机制。

近期论文

Huang P, Zhuang B, Zhang H, Yan H, Xiao Z, Li W, Zhang J, Tang Q, Hu K, Koeffler HP, Wang J*.Dong Yin*. Clin Cancer Res, Hepatitis B virus X protein (HBx) is responsible for resistance to targeted therapies in hepatocellular carcinoma: ex vivo culture evidence. 2015 Oct 1;21(19):4420-30. (Co-Correspondence Author) De-Chen Lin*, Liang Xu, Ye Chen, Haiyan Yan, Masaharu Hazawa, Ngan Doan, Jonathan W. Said, Ling-Wen Ding, Li-Zhen Liu, Henry Yang, Shizhu Yu, Michael Kahn, Dong Yin*, H. Phillip Koeffler. Genomic and functional analysis of the E3 ligase PARK2 in glioma. Cancer Research. 2015, 75(9):1815-27. (Co-Correspondence Author) Heyun Zhang, Wenbin Li, P. Huang, L. Lin, H. Ye, Z. Xiao, D. Lin, HP. Koeffler，Jie Wang*, Dong Yin*. Expression of CCN Family Members Correlates with Clinical Features in Hepatocellular Carcinoma. 2015, Oncology Reports 33: 1481-1492. (Co-Correspondence Author) Jin S, Wang K, Xu K, Xu J, Sun J, Chu Z, Lin D, Koeffler PH, Wang J, Yin Dong. Oncogenic function and prognostic significance of protein tyrosine phosphatase PRL-1 in hepatocellular carcinoma.Oncotarget. 2014 Jun 15;5(11):3685-96.(Co-Correspondence Author) Lin DC, Hao JJ, Nagata Y, Xu L, Shang L, Meng X, Sato Y, Okuno Y, Varela AM, Ding LW, Garg M, Liu LZ, Yang H, Yin Dong, Shi ZZ, Jiang YY, Gu WY, Gong T, Zhang Y, Xu X, Kalid O, Shacham S, Ogawa S, Wang MR, Koeffler HP.Genomic and molecular characterization of esophageal squamous cell carcinoma.Nat Genet. 2014 Mar 30. 46(5), pp 467-473 Xu L, Lin DC, Yin Dong, Koeffler HP. An emerging role of PARK2 in cancer. J MolMed (Berl). 2014 Jan;92(1):31-42. Epub 2013 Dec3 (Co-Correspondence Author) Lin DC, Xu L, Ding LW, Sharma A, Liu LZ, Yang H, Tan P, Vadgama J, Karlan BY, Lester J, Urban N, Schummer M, Doan N, Said JW, Sun H, Walsh M, Thomas CJ, Patel P, Dong Yin, Chan D, Koeffler HP. Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers. ProcNatlAcadSci U S A. 2013 Apr 9;110(15):6109-14. Lin L, Gaut D, Hu K, Yan H, Yin Dong, Koeffler HP. Dual targeting of glioblastomamultiforme with a proteasome inhibitor (Velcade) and a phosphatidylinositol3-kinase inhibitor (ZSTK474). Int J Oncol. 2014 Feb;44(2):557-62. Epub 2013 Dec 2.(Correspondence Author) Tang W, Yu F, Yao H, Cui X, Jiao Y, Lin L, Chen J, Yin Dong, Song E, Liu Q.miR-27a regulates endothelial differentiation of breast cancer stem like cells.Oncogene. 2014；33(20):2629-38 Hayano T, Garg M, Dong Yin, Sudo M, Kawamata N, Shi S, Chien W, Ding LW, Leong G, Mori S, Xie D, Tan P, Koeffler HP. SOX7 is down-regulated in lung cancer. J ExpClin Cancer Res. 2013 Apr 4;32(1):17. [Epub ahead of print] Dong Yin, Yang WG, Weissberg J, Goff CB, Chen W, Kuwayama Y, Leiter A, Xing H, Meixel A, Gaut D, Kirkbir F, Sawcer D, Vernier PT, Said JW, Gundersen MA, Koeffler HP (2012),Cutaneous Papilloma and Squamous Cell Carcinoma Therapy Utilizing Nanosecond Pulsed Electric Fields (nsPEF). PLOS ONE 2012;7(8):e43891 (Correspondence Author) Dong Yin, Seishi Ogawa, Norihiko Kawamata, Amanda Leiter, Michelle Ham, Dong Li, Ngan B Doan, Jonathan W. Said, Keith L. Black, H. Phillip Koeffler (2013). miR-34a functions as a tumor suppressor modulating EGFR in glioblastoma multiforme. Oncogene, 2013 Feb 28;32(9):1155-63. (Correspondence Author) Yin Z, Liu C, Chen Y, Bai Y, Shang C, Yin R, Dong Yin, Wang J. Timing of hepatectomy in resectable synchronous colorectal liver metastases (SCRLM): Simultaneous or Delayed? Hepatology 2013 Jun;57(6):2346-57 (Co-Correspondence Author) Yin Z, Fan X, Ye H, Dong Yin, Wang J. Short- and Long-term Outcomes after Laparoscopic and Open Hepatectomy for Hepatocellular Carcinoma: A Global Systematic Review and Meta-analysis. Ann SurgOncol. 2012 Oct 26.20(4):1203-15 Yin Z, Dong Yin, Wang J. A meta-analysis for percutaneous tumour ablation in patients with small hepatocellular carcinoma: highlighting combined strategy in the future. Gut. 2013;62(3):477-478 Yang YL, Fan Y, Lang RG, Gu F, Ren MJ, Zhang XM, Yin Dong, Fu L. Genetic heterogeneity of HER2 in breast cancer: impact on HER2 testing and its clinicopathologic significance. Breast Cancer Res Treat. 2012 Aug;134(3):1095-102. Epub 2012 Apr 5. Liu F, Lang R, Zhao J, Zhang X, Pringle GA, Fan Y, Yin Dong, Gu F, Yao Z, Fu L. CD8⁺ cytotoxic T cell and FOXP3⁺ regulatory T cell infiltration in relation to breast cancer survival and molecular subtypes. Breast Cancer Res Treat. 2011 Nov;130(2):645-55. Epub 2011 Jun 30. Chien W, O'Kelly J, Lu D, Leiter A, Sohn J, Dong Yin, Karlan B, Vadgama J, Lyons KM, Koeffler HP (2011). Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis. Int J Oncol. 2011;38(6):1741-1747 Weikai Chen, Amada Leiter, Dong Yin, Meiring M, Louw VJ, Koeffler HP (2010). Cucurbitacin B inhibits growth, arrests the cell cycle, and potentiates antiproliferative efficacy of cisplatin in cutaneous squamous cell carcinoma cell lines. International Journal of Oncology. 37(3):737-743. (Correspondence Author) Dong Yin, James O'Kelly, Daning Lu, Michelle Ham, Weikai Chen, Dong Xie, Ngan B Doan, Charles Wang, Jay Vadgama, Jonathan Said，Keith Black and H. Phillip Koeffler (2010). CTGF induces cell growth in vitro and in vivo, migration, as well as, drug resistance in glioblastoma multiforme. International Journal of Cancer. 127(10):2257-67 (Correspondence Author) Qi Cao, SigalGery, AzadehDashti, Dong Yin, Yan Zhou, Jiang Gu, H. Phillip Koeffler (2009). A Role for the Clock Gene Per1 in Prostate Cancer. Cancer Res. 69(19):7619-25 Thoennissen NH, Iwanski GB, Doan NB, Okamoto R, Lin P, Abbassi S, Song JH, Dong Yin, Toh M, Xie WD, Said JW, Koeffler HP. Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells. Cancer Res. 2009 Jul 15;69(14):5876-84 Dong Yin, Ogawa S, Kawamata N, Tunici P, Finocchiaro G, Eoli M, Ruckert C，Huynh T, Liu G, Kato M, Sanada M, Jauch A, Dugas M, Black K, Koeffle HP (2009). High resolution genomic copy number profiling of GBM by single nucleotide polymorphism DNA microarray. Molecular Cancer Research. 7(5):665-77. (Correspondence Author)