个人简历
于涛，副主任医师，医学博士，毕业于中山大学，现为中山大学孙逸仙纪念医院消化内科博士导师，胃肠专科副主任。中华医学会消化病分会营养与支持协作组全国委员、广东省医学会消化病分会委员兼秘书、广东省医学会胰腺病学组委员兼秘书、广东省医学会药物性肝损害学组委员兼秘书、广东省抗癌协会肿瘤内镜学组委员，美国马里兰大学医学院VA Health Center胃肠病研究所访问学者。独立开展我院首例双气囊小肠镜检查及内镜下消化道黏膜下肿物全层切除/剥离术及OTSC夹全层吻合术，填补了我院黏膜剥离术（ESD）及其相关技术的多项空白。
研究领域
从事肠上皮干细胞的基础与临床应用的研究，目前主攻于糖尿病状态下肠上皮结构与功能异常的机制及治疗靶点的探索。
近期论文
1.Yu T, Lu XJ, Li JY, Shan TD, Huang CZ, Ouyang H, Yang HS, Xu JH, Zhong W, Xia ZS, Chen QK. Overexpression of miR-429 impairs intestinal barrier function in diabetic mice by down-regulating occludin expression. Cell Tissue Res. 2016 Jun 14. [Epub ahead of print]（IF：2.948） 2.Yu T, Shan TD, Li JY, Huang CZ, Wang SY, Ouyang H, Lu XJ, Xu JH, Zhong W, Chen QK. Knockdown of linc-UFC1 suppresses proliferation and induces apoptosis of colorectal cancer. Cell Death Dis. 2016 May 19;7:e2228. (IF：5.378) 3. Shan TD, Ouyang H, Yu T*, Li JY, Huang CZ, Yang HS, Zhong W, Xia ZS, Chen QK. miRNA-30e regulates abnormal differentiation of small intestinal epithelial cells in diabetic mice by downregulating Dll4 expression. Cell Prolif. 2016 Feb;49(1):102-14. (IF：3.084) 4. Ouyang H, Yang HS, Yu T*, Shan TD, Li JY, Huang CZ, Zhong W, Xia ZS, Chen QK. MEK/ERK pathway activation by insulin receptor isoform alteration is associated with the abnormal proliferation and differentiation of intestinal epithelial cells in diabetic mice. Mol Cell Biochem. 2016 Feb;413(1-2):165-78. (IF：2.613) 5.Shan TD, Xu JH, Yu T*, Li JY, Zhao LN, Ouyang H, Luo S, Lu XJ, Huang CZ, Lan QS, Zhong W, Chen QK. Knockdown of linc-POU3F3 suppresses the proliferation, apoptosis, and migration resistance of colorectal cancer. Oncotarget. 2016 Jan 5;7(1):961-75. (IF：5.008) 6.Huang CZ, Yu T, Chen QK. DNA Methylation Dynamics During Differentiation, Proliferation, and Tumorigenesis in the Intestinal Tract. Stem Cells Dev. 2015 Dec 1;24(23):2733-9.（Review）(IF：3.777) 7. Luo S, Li JY, Zhao LN, Yu T*, Zhong W, Xia ZS, Shan TD, Ouyang H, Yang HS, Chen QK. Diabetes mellitus increases the risk of colorectal neoplasia: An updated meta-analysis. Clin Res Hepatol Gastroenterol. 2016 Feb;40(1):110-23.(IF：1.872) 8. Lai Y, Zhong W, Yu T*, Xia ZS, Li JY, Ouyang H, Shan TD, Yang HS, Chen QK. Rebamipide Promotes the Regeneration of Aspirin-Induced Small-Intestine Mucosal Injury through Accumulation of β-Catenin. PLoS One. 2015 Jul 2;10(7):e0132031. (IF：3.057) 9. Zhong XY, Yu T#, Zhong W, Li JY, Xia ZS, Yuan YH, Yu Z, Chen QK. Lgr5 positive stem cells sorted from small intestines of diabetic mice differentiate into higher proportion of absorptive cells and Paneth cells in vitro. Dev Growth Differ. 2015 Aug;57(6):453-65. (IF：2.412) 10. Yu T, Qing Q, Deng N, Min XH, Zhao LN, Li JY, Xia ZS, Chen QK. CXCR4 positive cell-derived Pdx1-high/Shh-low cells originated from embryonic stem cells improve the repair of pancreatic injury in mice. Cell Biol Int. 2015 Sep;39(9):995-1006. (IF：1.663) 11. Chen H, Min XH, Wang QY, Leung FW, Shi L, Zhou Y, Yu T, Wang CM, An G, Sha WH, Chen QK. Pre-activation of mesenchymal stem cells with TNF-α, IL-1β and nitric oxide enhances its paracrine effects on radiation-induced intestinal injury. Sci Rep. 2015 Mar 3;5:8718. (IF：5.228) 12. Zhao LN, Yu T#, Li CQ, Lai Y, Chen QK. Somatostatin administration prior to ERCP is effective in reducing the risk of post-ERCP pancreatitis in high-risk patients. Exp Ther Med. 2014 Aug;8(2):509-514. (IF：1.28) 13. Li JY, Yu T#, Xia ZS, Chen GC, Yuan YH, Zhong W, Zhao LN, Chen QK. Enhanced proliferation in colorectal epithelium of patients with type 2 diabetes correlates with β-catenin accumulation. J Diabetes Complications. 2014 Sep-Oct;28(5):689-97. (IF：2.955) 14. Min XH, Yu T#, Qing Q, Yuan YH, Zhong W, Chen GC, Zhao LN, Deng N, Zhang LF, Chen QK. Abnormal differentiation of intestinal epithelium and intestinal barrier dysfunction in diabetic mice associated with depressed Notch/NICD transduction in Notch/Hes1 signal pathway. Cell Biol Int. 2014 Oct;38(10):1194-204. (IF：1.663) 15. Zhong W, Yu Z, Zhan J, Yu T, Lin Y, Xia ZS, Yuan YH, Chen QK. Association of serum levels of CEA, CA199, CA125, CYFRA21-1 and CA72-4 and disease characteristics in colorectal cancer. Pathol Oncol Res. 2015 Jan;21(1):83-95. (IF：1.94) 16. Zhao LN, Li JY, Yu T*, Chen GC, Yuan YH, Chen QK. 5-Aminosalicylates reduce the risk of colorectal neoplasia in patients with ulcerative colitis: an updated meta-analysis. PLoS One. 2014 Apr 7;9(4):e94208. (IF：3.234)
