个人简历

严励，中山大学孙逸仙纪念医院副院长，内分泌科主任，二级教授，中山大学名医，博士生导师。现任中华医学会内分泌分会常委，中华医学会内分泌分会肥胖学组组长，广东省内分泌学会主委，广东省保健医学会内分泌分会副主任委员，中国老年保健医学研究会老年内分泌与代谢病分会副主任委员，《中国实用内科杂志》副主编，曾任中华医学会糖尿病分会足病组副组长。

研究领域

1)胰岛β细胞功能在2型糖尿病发病机理中的作用 (2)糖尿病足的基础和临床系列研究

近期论文

[1] Ping Zhu, Chuan Yang, Li-hong Chen, Li Yan(通讯作者). Impairment of human keratinocyte mobility and proliferation by advanced glycation end products-modified BSA. Archives of Dermatological Research. 2011,303(5) :339-350. [2] Ping Zhu, Men Ren, Chuan Yang, Li-hong Chen, Li Yan(通讯作者). Involvement of RAGE, MAPK and NF-κB pathways in AGEs-induced MMP-9 expression in HaCaT keratinocytes. Experiment Dermatology. 2011,10(21):123-129. [3] ShaoYun Hao, Meng Ren, Chuan Yang, DiaoZhu Lin, LiHong Chen, Ping Zhu, Hua Cheng, Li Yan(通讯作者). Activation of skin renin-angiotensin system in diabetic rats. Endocrine. 2011,39(3):242-250. [4] Chuan Yang, Ping Zhu, Li Yan (通讯作者), Li Hong Chen, Meng Ren, GuoJuan Lao. Dynamic changes in matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 levels during wound healing in diabetic rats. J Am Podiatr Med Assoc. 2009, 99(6): 489-96. [5] GuoJuan Lao,Li Yan (通讯作者), Chuan Yang, LiMing Zhang, Li Hong Chen. Controlled-released of epidermal growth factor from hydrogels accelerates wound healing of diabetic rats. J Am Podiatr Med Assoc . 2012, 102(2):89-98 [6] SN Xue , Lei J, C Yang, DZ Lin, Li Yan (通讯作者). The Biological Behaviors of Rat Dermal Fibroblasts Can Be Inhibited by High Levels of MMP9. 2012:494579 [7] XY Xie, C Yang, M Ren, SY Hao, P Zhua, Li Yan (通讯作者). Inhibition of matrix metalloproteinase 9 expression in rat dermal fibroblasts using small interfering RNA.J Am Podiatr Med Assoc. 2012 Jul-Aug;102(4):299-308. [8] Li Ling*, Meng Ren*, Chuan Yang, Guojuan Lao, Lihong Chen, Hengcong Luo, Zhimei Feng ,Li Yan(通讯作者).. Role of site-specific DNA demethylation in TNF-α-induced MMP9 expression in keratinocytes. Journal of Molecular Endocrinology.2013,50(3):279-290. [9] Meng Ren*, Shaoyun Hao*, Chuan Yang, Ping Zhu, Lihong Chen, Diaozhu Lin, Na Li,Li Yan(通讯作者). Angiotensin II Regulates Collagen Metabolism through Modulating Tissue Inhibitor of Metalloproteinase-1 in Diabetic Skin Tissues. Diabetes and Vascular Disease Research.2013,10(5):426-435. [10] Meng Ren*, Mu chao Wu*, Chang Zhen Shang, Xiao yi Wang, Jing Lu Zhang, Hua Cheng, Ming tong Xu,Li Yan(通讯作者).Predictive factors of thyroid cancer in patients with Graves’disease.World Journal of Surgery. 2014,38(1):80-87 [11] D Ma, LM Zhang, C Yang, L Yan(通讯作者). UV photopolymerized hydrogels with β-cyclodextrin moieties. Journal of Polymer Research, 2008, 15(4): 301-07. [12] SP Zhao, LM Zhang, D Ma, C Yang, L Yan(通讯作者). Fabrication of novel supramolecular hydrogels with high mechanical strength and adjustable thermosensitivity. The Journal of Physical Chemistry B, 2006, 110(33): 16503-07. [13] LM Zhang, C Yang, L Yan(通讯作者). Perspectives on: Strategies to fabricate starch-based hydrogels with potential biomedical applications. Journal of Bioactive and Compatible Polymers, 2005, 20(3): 297-314. [14] LM Zhang, GH Wang, HW Lu, C Yang, L Yan(通讯作者). A new class of starch-based hydrogels incorporating acrylamide and vinyl pyrrolidone: Effects of reaction variables on water sorption behavior. Journal of Bioactive and Compatible Polymers, 2005, 20(5): 491-501. [15] Liming Z, Chuan Y, Li Y(通讯作者).Perspectives on: Strategies to Fabricate Starchbased Hydrogels with Potential Biomedical Applications. J Bioact Compat Pol.2005;20: 297-314. [16] Song F, Zhang LM, Chuan Y, Yan L(通讯作者). Genipin-crosslinked casein hydrogels for controlled drug delivery. Int J Pharm. 2009;373:41-47. [17] Junjie D, Na L, Kaijin M, Chuan Y, Li Y(通讯作者) and Li-Ming Z：Star-shaped polymers consisting of a β-cyclodextrin core and poly(amidoamine) dendron arms: binding and release studies with methotrexate and siRNA. J. Mater. Chem, 2011,21, 5273-5281. [18] Zeng YJ, Zeng FQ, Dai L, Yang Chuan, Lin BZ, Zheng DH, Liu D, Yan L(通讯作者), Ren M, Cheng H. Characteristics and risk factors for hyperglycemia in Chinese female patients with systemic lupus erythematosus. Lupus. 2010;19:1344-1350. [19] Zhao SP, Zhang LM, Ma D, Yang Chuan, Yan L(通讯作者). Fabrication of novel supramolecular hydrogels with high mechanical strength and adjustable thermosensitivity. J Phys Chem B. 2006;110:16503-16507.