个人简历

教育经历\r
2002年09月—2006年07月 北京大学生命科学学院，生物科学专业，获学士学位；\r
2006年11月—2011年11月 香港大学化学系，化学生物学专业， 获博士学位。\r
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工作经历\r
2011年9月—2014年10月 哈佛大学医学院/波士顿儿童医院，博士后；\r
2014年11月至今 中山大学化学与化学工程学院，副教授，硕士生导师。\r
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讲授课程\r
化学生物学导论，配位化学（研究生），普通化学实验，有机化学实验

研究领域

"""""生物无机化学方向：金属抗菌、抗癌药物设计合成及作用机理研究；小分子药物靶点结构生物学研究。"

近期论文

“Bismuth-induced Inactivation of Ferric Uptake Regulator from Helicobacter pylori.” X He, X Liao, H Li, W Xia*, H Sun*, Inorg. Chem., 2017, 56, 15041-15048\r
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“Targeting the Thioredoxin Reductase-Thioredoxin System from Staphylococcus aureus by Silver Ions.” X Liao, F Yang, H Li, PK So, Z Yao, YT, W Xia*, H Sun*, Inorg. Chem., 2017, 56, 14823-14830\r
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“Identification of Catabolite Control Protein A from Staphylococcus aureus as a Target of Silver Ions.” X Liao, F Yang, R Wang, X He, H Li, YT Richard, W Xia*, H Sun*, Chem. Sci., 2017, 8, 8061-8066\r
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“Integrative approach for the analysis of the proteome-wide response to bismuth drugs in Helicobacter pylori” Y Wang, L Hu, F Xu, Q Quan, YT Lai, W Xia, Y Yang, YY Chang, X Yang, Z Chai, J Wang, IK Chu, H Li, H Sun*, Chem. Sci., 2017, 8, 4626-4633\r
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“Relating conformation to function in integrin α5β1.” Y. Su#, W. Xia#, J. Li, T. Walz, M. J. Humphries, D. Vestweber, C. Cabanas, C. Lu and T. A. Springer*, Proc. Natl. Acad. Sci. USA, 2016, 113, E3872-3881. (#: Co-first authors)\r
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“Metal ion and ligand binding of integrin α5β1.” W. Xia and T. A. Springer*, Proc. Natl. Acad. Sci. USA, 2014, 111, 17863-17868.\r
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“Functional disruption of HypB, a GTPase of Helicobacter pylori by bismuth.” W. Xia, H. Li and H. Sun*, Chem. Commun., 2014, 50, 1611-1614.\r
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“Histidine-rich Proteins in Prokaryotes: Metal Homeostasis and Environmental Habitat-related Occurrence.” T. Cheng#, W. Xia#, P. Wang, F. Huang, J. Wang and H. Sun*, Metallomics, 2013, 5, 1423-1429. (#: Co-first authors)\r
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“Metallo-GTPase HypB from Helicobacter pylori and Its Interaction with Nickel Chaperone Protein HypA.” W. Xia, H. Li, X. Yang, K.-B. Wong and H. Sun*, J. Biol. Chem., 2012, 287, 6753-6763.\r
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“Structure of a Nickel Chaperone, HypA, from Helicobacter pylori Reveals Two Distinct Metal Binding Sites.”W. Xia, H. Li, K.-H. Sze and H. Sun*, J. Am. Chem. Soc., 2009, 131, 10031-10040.\r
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