个人简历

徐康，助理研究员，医学博士。现就职于中山大学孙逸仙纪念医院普外科。

研究领域

主要从事肿瘤与代谢的相关机制研究，已完成的科研工作中以疾病动物模型为主，曾完成肝脏特异性高表达miR-155、miR-21小鼠的构建，并利用这些转基因小鼠进行了相关研究，发现miR-155可通过协同调节胰岛素信号通路相关的多个基因而增强小鼠胰岛素敏感性。

近期论文

1. Wang X, Li C, Liang A, Peng Y, Sun J, Huang D, Xu K*, Ye W. Regulation of a disintegrins and metalloproteinase with thrombospondin motifs 7 during inflammation in nucleus pulposus (NP) cells: role of AP-1, Sp1 and NF-κB signaling. Inflamm Res. 2016;65(12):951-62. (IF: 2.557) 2. Lin X, Qin Y, Jia J, Lin T, Lin X, Chen L, Zeng H, Han Y, Wu L, Huang S, Wang M, Huang S, Xie R, Liang L, Liu Y, Liu R, Zhang T, Li J, Wang S, Sun P, Huang W, Yao K, Xu K*, Du T, Xiao D. MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice. PLoS Genet. 2016;12(10):e1006308. (IF:6.661) 3. Xu K, Wang X, Zhang Q, Liang A, Zhu H, Huang D, Li C, Ye W. Sp1 downregulates proinflammatory cytokine‑induced catabolic gene expression in nucleus pulposus cells. Mol Med Rep. 2016;14(4):3961-8. (IF:1.559) 4. Lin X, Zhao W, Jia J, Lin T, Xiao G, Wang S, Lin X, Liu Y, Chen L, Qin Y, Li J, Zhang T, Hao W, Chen B, Xie R, Cheng Y, Xu K, Yao K, Huang W, Xiao D, Sun Y. Ectopic expression of Cripto-1 in transgenic mouse embryos causes hemorrhages, fatal cardiac defects and embryonic lethality. Sci Rep. 2016;6:34501. (IF: 5.228) 5. Xie R, Lin X, Du T, Xu K#, Shen H, Wei F, Hao W, Lin T, Lin X, Qin Y, Wang H, Chen L, Yang S, Yang J, Rong X, Yao K, Xiao D, Jia J, Sun Y. Targeted Disruption of miR-17-92 Impairs Mouse Spermatogenesis by Activating mTOR Signaling Pathway. Medicine (Baltimore). 2016;95(7):e2713. (IF:2.133) 6. Xu K, Chen W, Wang X, Peng Y, Liang A, Huang D, Li C, Ye W. Autophagy attenuates the catabolic effect during inflammatory conditions in nucleus pulposus cells, as sustained by NF-κB and JNK inhibition. Int J Mol Med. 2015;36(3):661-8. (IF:2.348) 7. Lin X, Jia J, Du T, Li W, Wang X, Wei J, Lin X, Zeng H, Yao L, Chen X, Zhuang J, Weng J, Liu Y, Lin J, Wu Q, Wang W, Yao K, Xu K*, Xiao D. Overexpression of miR-155 in the liver of transgenic mice alters the expression profiling of hepatic genes associated with lipid metabolism. PLoS One. 2015;10(3):e0118417. (IF: 3.057) 8. Du T, Jia J, Lin X, Xie R, Li J, Xiao D, Xu K*. Generation of Rm21LG transgenic mice: a powerful tool to generate conditional overexpression of miR-21 that is involved in oncogenesis. Biotechnol Lett. 2014;36(1):9-20. (IF:1.639) 9. Mao K, Zhang J, He C, Xu K, Liu J, Sun J, Wu G, Tan C, Zeng Y, Wang J, Xiao Z. Restoration of miR-193b sensitizes Hepatitis B virus-associated hepatocellular carcinoma to sorafenib. Cancer Lett. 2014;352(2):245-52. (IF: 5.992) 10. Jin S, Wang K, Xu K, Xu J, Sun J, Chu Z, Lin D, Koeffler PH, Wang J, Yin D. Oncogenic function and prognostic significance of protein tyrosine phosphatase PRL-1 in hepatocellular carcinoma. Oncotarget. 2014;5(11):3685-96. (IF: 5.008) 11. Gao F, Zhao ZL, Zhao WT, Fan QR, Wang SC, Li J, Zhang YQ, Shi JW, Lin XL, Yang S, Xie RY, Liu W, Zhang TT, Sun YL, Xu K*, Yao KT, Xiao D. miR-9 modulates the expression of interferon-regulated genes and MHC class I molecules in human nasopharyngeal carcinoma cells. Biochem Biophys Res Commun. 2013;431(3):610-6. (IF: 2.371) 12. He C, Xu J, Zhang J, Xie D, Ye H, Xiao Z, Cai M, Xu K, Zeng Y, Li H, Wang J. High expression of trimethylated histone H3 lysine 4 is associated with poor prognosis in hepatocellular carcinoma. Hum Pathol. 2012;43(9):1425-35. (IF: 2.791) 13. Ye W, Xu K#, Huang D, Liang A, Peng Y, Zhu W, Li C. Age-related increases of macroautophagy and chaperone-mediated autophagy in rat nucleus pulposus. Connect Tissue Res. 2011;52(6):472-8. (IF: 1.411) 14. Wu G, Yu F, Xiao Z, Xu K, Xu J, Tang W, Wang J, Song E. Hepatitis B virus X protein downregulates expression of the miR-16 family in malignant hepatocytes in vitro. Br J Cancer. 2011;105(1):146-53. (IF: 5.569) 15. Sheng Z, Xu K#, Ou Y, Dai R, Luo X, Liu S, Su X, Wu X, Xie H, Yuan L, Liao E. Relationship of body composition with prevalence of osteoporosis in central south Chinese postmenopausal women. Clin Endocrinol (Oxf). 2011;74(3):319-24. (IF: 3.487) 16. Sheng ZF, Ye W, Wang J, Li CH, Liu JH, Liang QC, Li S, Xu K*, Liao EY. OPG knockout mouse teeth display reduced alveolar bone mass and hypermineralization in enamel and dentin. Arch Oral Biol. 2010;55(4):288-93. (IF: 1.733) 17. Li H, Xie H, Liu W, Hu R, Huang B, Tan YF, Xu K, Sheng ZF, Zhou HD, Wu XP, Luo XH. A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans. J Clin Invest. 2009 ;119(12):3666-77. (IF: 12.575) 18. Liu J, Xu K#, Wen G, Guo H, Li S, Wu X, Dai R, Sheng Z, Liao E. Comparison of the effects of genistein and zoledronic acid on the bone loss in OPG-deficient mice. Bone. 2008;42(5):950-9. (IF: 3.736)