个人简历

1995年获美国波士顿塔夫兹大学生命医学学院分子和细胞生理学博士学位\r
1995年-1998年于哈佛大学医学院细胞生物学系、麻省理工学院（MIT）生物系从事博士后工作\r
1998年起 在美国贝勒医学院任助理教授，历任副教授、正教授和讲席教授\r
2009年受聘为中山大学教授\r
2009-2015年，任中山大学生命科学学院院长\r
2011至今中山大学抗衰老中心主任、广州市抗衰老重点实验室主任

研究领域

""研究重点主要围绕衰老和再生的分子机制\r
研究方向包括：干细胞生长与分化、肿瘤生长和人体衰老机制、细胞端粒的结构、端粒蛋白的功能与作用机理、DNA损伤与修复、蛋白质间相互作用和信号传导网络、功能基因的高通量筛选和鉴定""""

近期论文

The Daxx/Atrx Complex Protects Tandem Repetitive Elements during DNA Hypomethylation by Promoting H3K9 Trimethylation. He Q, Kim H, Huang R, Lu W, Tang M, Shi F, Yang D, Zhang X, Huang J, Liu D, Songyang Z. Cell Stem Cell. 2015 Sep 3;17(3):273-86.\r
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Mir-23a Induces Telomere Dysfunction and Cellular Senescence by Inhibiting TRF2 Expression. Luo ZH, Feng XY, Wang HL, Xu WW, Zhao Y, Ma WB, Jiang SS, Liu D, Huang JJ*, Songyang Z*. Aging Cell 2014. (in press)\r
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TPP1 as a versatile player at the ends of chromosomes. Zhang, S., Luo, Z., Shi, G., Liu, D., Songyang, Z.,Huang, J.(2014). Frontiers in Biology 9,225-233.\r
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Structural Maintenance of Chromosomes Flexible Hinge Domain Containing 1 (SMCHD1) Promotes Non-homologous End Joining and Inhibits Homologous Recombination Repair upon DNA Damage. Tang, M., Li, Y., Zhang, X., Deng, T., Zhou, Z., Ma, W., and Songyang, Z. (2014a). J Biol Chem 289, 34024-34032.\r
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Disease mutant analysis identifies a novel function of DAXX in telomerase regulation and telomere maintenance. Journal of cell science. Tang, M., Li, Y., Zhang, Y., Chen, Y., Huang, W., Wang, D., Zaug, A.J., Liu, D., Zhao, Y., Cech, T.R., et al. (2014b).\r
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Human Urine-Derived Stem Cells Alone or Genetically-Modified with FGF2 Improve Type 2 Diabetic Erectile Dysfunction in a Rat Model. Ouyang B, Sun X, Han D, Chen S, Yao B, Gao Y, Bian J, Huang Y, Zhang Y, Wan Z, Yang B, Xiao H, Songyang Z, Liu G, Zhang Y, Deng C. PLoS One. 2014 Mar 24;9(3):e92825. doi: 10.1371/journal.pone.0092825. eCollection 2014.\r
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Fam118B, a novel component in Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability. Li Y, Fong KW, Tang M, Han X, Gong Z, Ma W, Hebert M, Songyang Z, Chen J. J Cell Sci. 2014 Feb 25. [Epub ahead of print]\r
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Telomere regulation in pluripotent stem cells. Huang Y, Liang P, Liu D, Huang J, Songyang Z. Protein Cell. 2014 Mar;5(3):194-202. doi: 10.1007/s13238-014-0028-1. Epub 2014 Feb 22.\r
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The Death-inducer Obliterator 1 (Dido1) Gene Regulates Embryonic Stem Cell Self-renewal. Liu Y, Kim H, Liang J, Lu W, Ouyang B, Liu D, Songyang Z. J Biol Chem. 2014 Feb 21;289(8):4778-86. doi: 10.1074/jbc.M113.486290. Epub 2013 Dec 17.\r
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Whole-genome screening identifies proteins localized to distinct nuclear bodies. Fong KW1, Li Y, Wang W, Ma W, Li K, Qi RZ, Liu D, Songyang Z, Chen J. J Cell Biol. 2013 Oct 14;203(1):149-64. doi: 10.1083/jcb.201303145.\r
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Large-scale screens of miRNA-mRNA interactions unveiled that the 3'UTR of a gene is targeted by multiple miRNAs. Zhou P, Xu W, Peng X, Luo Z, Xing Q, Chen X, Hou C, Liang W, Zhou J, Wu X, Songyang Z, Jiang S. PLoS One. 2013 Jul 9;8(7):e68204. doi: 10.1371/journal.pone.0068204. Print 2013.\r
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Ten-eleven translocation 1 (tet1) is regulated by o-linked N-acetylglucosamine transferase (ogt) for target gene repression in mouse embryonic stem cells. Shi, F.T., Kim, H., Lu, W., He, Q., Liu, D., Goodell, M.A., Wan, M., and Songyang Z.*. 2013 Jul 19J Biol Chem 288, 20776-20784.\r
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The telomere-associated homeobox-containing protein TAH1 participates in telomere maintenance in ALT Cells. Xuyang Feng, Zhenhua Luo, Shuai Jiang, Feng Li, Xin Han, Yang Hu, Dan Wang, Yong Zhao, Wenbin Ma, Dan Liu, Junjiu Huang, and Zhou Songyang. J Cell Sci jcs.128512; Advance Online Article June 26, 2013, doi:10.1242/jcs.128512\r
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Akt regulates TPP1 homodimerization and telomere protection. Xin Han, Dan Liu, Yi Zhang, Yujing Li, Weisi Lu, Junjie Chen, Zhou Songyang. Aging Cell. Volume 12, Issue 6, pages 1091–1099, December 2013 .Article first published online: 11 AUG 2013 DOI: 10.1111/acel.12137.\r
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Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitment. Zhang Y, Chen LY, Han X, Xie W, Kim H, Yang D, Liu D, Songyang Z. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5457-62. doi: 10.1073/pnas.1217733110. Epub 2013 Mar 18.\r
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MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. Fong KW, Leung JW, Li Y, Wang W, Feng L, Ma, Liu D, Songyang Z, Chen J.J Cell Sci. 2012 Dec 21.