个人简历

刘强，教授、主任医师、研究员，外科学博士，1996年毕业于中南大学湘雅医学院七年制临床医学专业，获外科学硕士学位，毕业后在湘雅医院任普外科医生。2000至2004 年获新加坡全额奖学金资助于新加坡国立大学医学院外科攻读并获得博士学位。随后分别在新加坡国立大学肿瘤研究所及美国哈佛大学医学院Dana Farber癌症研究所任博士后研究员，2008年晋升为哈佛大学医学院Dana Farber癌症研究所及Brigham and Women医院肿瘤科讲师(Instructor in Medicine)。现为中山大学孙逸纪念医院乳腺外科博士研究生导师，乳腺肿瘤医学部副主任，对外交流与拓展办公室主任

研究领域

""1）非编码RNA在乳腺肿瘤发生发展中的作用及机制研究\r
2）肿瘤耐药的机制研究\r
3）肿瘤微环境在乳腺癌发生发展中的作用""""

近期论文

Gong C, Qu S, Lv XB, Liu B, Tan W, Nie Y, Su F, Liu Q*, Yao H*, Song E*. BRMS1L suppresses breast cancer metastasis by inducing epigenetic silence of FZD10. Nat Commun, 2014, 5:5406. (* co-corresponding author) (IF=11.329)\r
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Gong C, Nie Y, Qu S, Liao JY, Cui X, Yao H, Zeng Y, Su F, Song E*, Liu Q*. miR-21 Induces Myofibroblast Differentiation and Promotes the Malignant Progression of Breast Phyllodes Tumors. Cancer Res. 2014, 74(16):4341-4352. (* co-corresponding author) (IF=8.556)\r
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Gong C, Qu S, Liu B, Pan S, Jiao Y, Nie Y, Su F, Liu Q*, Song E*. MiR-106b expression determines the proliferation paradox of TGF-β in breast cancer cells. Oncogene, 2015, 34(1):84-93.. (* co-corresponding author) (IF=7.932)\r
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Tang W, Yu F, Yao H, Cui X, Jiao Y, Lin L, Chen J, Yin D, Song E*, Liu Q*. miR-27a regulates endothelial differentiation of breast cancer stem like cells. Oncogene. 2014, 33(20):2629-38. (* co-corresponding author) (IF=7.932)\r
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Chu J, Zhu Y, Liu Y, Sun L, Lv X, Wu Y, Hu P, Su F, Gong C, Song E, Liu B*, Liu Q*. E2F7 overexpression leads to tamoxifen resistance in breast cancer cells by competing with E2F1 at miR-15a/16 promoter. Oncotarget. 2015, 6(31):31944-57. (*, co-corresponding author) ( IF=5.008)\r
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Liu J, Guo H, Mao K, Zhang K，Deng H, Liu Q. Impact of estrogen receptor-β expression on breast cancer prognosis: a meta-analysis. Breast Cancer Res Treat. 2016, 156(1):149-62.(IF= 4.085)\r
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Liu J, Jiang W, Mao K, An Y, Su F, Kim BYS, Liu Q*, Jacobs LK*. Elevated Risks of Subsequent Endometrial Cancer Development among Breast Cancer Survivors with Different Hormone Receptor Status: A SEER Analysis. Breast Cancer Res Treat, 2015, 150(2):439-45. (* co-corresponding author) (IF= 4.085)\r
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Li S, Liu J, Yang Y, Zeng Y, Deng H, Jia H, Li Q, Feng H, Li Y, Song E, Liu Q*, Su F*. Impact of atypical hyperplasia at margins of breast-conserving surgery on the recurrence of breast cancer. J Cancer Res Clin Oncol. 2014, 140(4):599-605 (* co-corresponding author)( IF= 3.141)\r
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Liu B#, Sun L#, Liu Q#, Gong C#, Yao Y, Lv X, Lin L, Yao H, Su F, Li D, Zeng M, Song E. A Cytoplasmic NFkB Interacting Long Noncoding RNA Blocks IkB Phosphorylation and Suppresses Breast Cancer Metastasis. Cancer Cell, 2015, 27(3):370-81, the cover story of the issue. (# co-first author) （IF= 23.214）\r
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Su S#, Liu Q#, Chen J, Chen J, Chen F, He C, Wu W, Lin L，Li H, Huang D, Huang W, Yu F, Zhang J, Cui X, Zheng F, Yao H, Su F, Song E. A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis. Cancer Cell. 2014, 25(5):605-620 (#, co-first author) （IF= 23.214）\r
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Liu Q, Teh M, Ito K, Shah N, Ito Y, Yeoh KG. CDX2 expression is progressively decreased in human gastric intestinal metaplasia, dysplasia and cancer. Mod Pathol, 2007, 20(12):1286-1297(IF=5.485)\r
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Liu Q, Chan STF, Mahendran R. Nitric Oxide induces cyclooxygenase expression and inhibits cell growth in colon cancer cell lines. Carcinogenesis, 2003, 24(4): 637-642 (IF=4.874)\r
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Liu Q, Boudot A, Ni J, Hennessey T, Beauparlant S, Rajabi H, Zahnow CA, Ewen ME. Cyclin D1 and C/EBPβ LAP1 operate in a common pathway to promote mammary epithelial cell differentiation. Mol Cell Biol. 2014, 34(16):3168-3179. (IF=4.427)\r
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Liu Q, Inoue H, Mahendran R. Transcriptional regulation of the COX-2 expression by nitric oxide in colon cancer cell lines. Oncol Rep. 2008, 19(1):269-274(IF= 2.486)\r
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Chen J, Yao Y, Gong C, Yu F, Su S, Chen J, Liu B, Deng H, Wang F, Lin L, Yao H, Su F, Anderson KS, Liu Q, Ewen ME, Yao X, Song E. CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell 2011, 19(4):541-555. （IF= 23.214）\r
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Chang TL, Ito K, Ko TK, Liu Q, Salto-Tellez M, Yeoh KG, Ito Y. Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cells. Gastroenterology. 2010, 138(1):255-265 (IF=18.187)\r
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Yao YD, Sun TM, Huang SY, Dou S, Lin L, Chen JN, Ruan JB, Mao CQ, Yu FY, Zeng MS, Zang JY, Liu Q, Su FX, Zhang P, Lieberman J, Wang J, Song E. Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2+ Breast Cancer Growth and Metastasis. Sci Transl Med, 2012, 18(4):130ra48. (IF=16.264)\r
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Müller CI, Luong QT, Shih LY, Jones LC, Desmond JC, Kawamata N, Tcherniantchouk O, Liu Q, Ito K, Osato M, Ito Y, Tefferi A, de Vos S, Koeffler HP. Identification of marker genes including RUNX3 (AML2) that discriminate between different myeloproliferative neoplasms and normal individuals. Leukemia. 2008, 22(9):1773-1778(IF=12.104)\r
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Su S, Zhao Q, He C, Huang D, Liu J, Chen F, Chen J, Liao JY, Cui X, Zeng Y, Yao H, Su F, Liu Q, Jiang S, Song E. miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program. Nat Commun. 2015, 6:8523. doi: 10.1038/ncomms9523. (IF=11.329)\r
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Lau QC, Raja E, Salto-Tellez M, Liu Q, Ito K, Inoue M, Putti TC, Loh M, Ko TK, Huang C, Ito Y, Sukumar S. RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer. Cancer Research, 2006, 66(13): 6512-6520 (IF= 8.556)