个人简历

李伟忠，中山大学百人计划2016年国外引进高层次人才，中山大学中山医学院和精准医学科学中心教授、博士生导师，承担国家重点研发计划专项课题“精准医学大数据的整合与注释”，现任广东生物信息学会副理事长，中国人工智能学会生物信息学与人工生命专委会委员。曾任欧洲生物信息研究所（EMBL-European Bioinformatics Institute，英国剑桥）高级软件工程师 （2009-2016）。在Nucleic Acids Research、Molecular Systems Biology、PNAS、Bioinformatics等国际生物信息领域权威期刊发表论文20多篇，其中专著两部，总他引SCI过 4000、Google Scholar 过1万。担任 Nucleic Acids Research，Bioinformatics, Database (Oxford)等国际权威期刊评审。国外期间，曾设计和实施欧洲生物信息研究所以高性能计算为基础的核心生物大数据分析应用大平台，服务超过180个国家和地区；建立了全球最完整的生物序列专利数据库群；设计开发的蛋白序列精确迭代检索引擎 PSI-Search；深度参与国际重大生物信息项目，如国际蛋白数据库UniProt、国际核酸数据库 ENA/GenBank、基因组数据库 Ensembl Genomes、多序列比对工具 Clustal Omega、大分子功能注释工具InterProScan，为世界范围的生物医学大数据建设和共享作出了积极贡献。

研究领域

主要从事面向精准医学大数据的研究，包括生物医学数据的整合和注释、精准高效检索、大型软件工作流开发

近期论文

Pearson WR, Li W, Lopez R. Query-seeded iterative sequence similarity searching improves selectivity 5-20-fold. Nucleic Acids Res. 2016 Dec . PMID: 27923999.Li W, Cowley A, Uludag M, Gur T, McWilliam H, Squizzato S, Park YM, Buso N, Lopez R. The EMBL-EBI bioinformatics web and programmatic tools framework. Nucleic Acids Res. 2015 Jul;43(W1) W580-4. PMID: 25845596Sievers F, Wilm A, Dineen D, Gibson TJ, Karplus K, Li W, Lopez R, McWilliam H, Remmert M, Söding J, Thompson JD, Higgins DG. Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega. Mol Syst Biol. 2011;7 539. PMID: 21988835UniProt Consortium. UniProt: a hub for protein information. Nucleic Acids Res. 2015 Jan;43(Database issue) D204-12. PMID: 25348405Li W, McWilliam H, de la Torre AR, Grodowski A, Benediktovich I, Goujon M, Nauche S, Lopez R. Non-redundant patent sequence databases with value-added annotations at two levels. Nucleic Acids Res. 2010 Jan;38(Database issue) D52-6. PMID: 19884134 Li W, McWilliam H, Goujon M, Cowley A, Lopez R, Pearson WR. PSI-Search: iterative HOE-reduced profile SSEARCH searching. Bioinformatics. 2012 Jun;28(12) 1650-1651. PMID: 22539666 Goujon M, McWilliam H, Li W, Valentin F, Squizzato S, Paern J, Lopez R. A new bioinformatics analysis tools framework at EMBL-EBI. Nucleic Acids Res. 2010 Jul;38(Web Server issue) W695-9. PMID: 20439314 McWilliam H, Li W, Uludag M, Squizzato S, Park YM, Buso N, Cowley AP, Lopez R. Analysis Tool Web Services from the EMBL-EBI. Nucleic Acids Res. 2013 Jul;41(Web Server issue) W597-600. PMID: 23671338Jones P, Binns D, Chang HY, Fraser M, Li W, McAnulla C, McWilliam H, Maslen J, Mitchell A, Nuka G, Pesseat S, Quinn AF, Sangrador-Vegas A, Scheremetjew M, Yong SY, Lopez R, Hunter S. InterProScan 5: genome-scale protein function classification. Bioinformatics. 2014 May;30(9) 1236-1240. PMID: 24451626Li W, Gracey AY, Mello LV, Brass A, Cossins AR. ExprAlign--the identification of ESTs in non-model species by alignment of cDNA microarray expression profiles. BMC Genomics. 2009;10 560. PMID: 19939286Li W, Kondratowicz B, McWilliam H, Nauche S, Lopez R. The annotation-enriched non-redundant patent sequence databases. Database (Oxford). 2013;2013 bat005. PMID: 23396323Silvester N, Alako B, Amid C, Cerdeño-Tárraga A, Cleland I, Gibson R, Goodgame N, Ten Hoopen P, Kay S, Leinonen R, Li W, Liu X, Lopez R, Pakseresht N, Pallreddy S, Plaister S, Radhakrishnan R, Rossello M, Senf A, Smirnov D, Toribio AL, Vaughan D, Zalunin V, Cochrane G. Content discovery and retrieval services at the European Nucleotide Archive. Nucleic Acids Res. 2015 Jan;43(Database issue) D23-9. PMID: 25404130Squizzato S, Park YM, Buso N, Gur T, Cowley A, Li W, Uludag M, Pundir S, Cham JA, McWilliam H, Lopez R. The EBI Search engine: providing search and retrieval functionality for biological data from EMBL-EBI. Nucleic Acids Res. 2015 Jul;43(W1) W585-8. PMID: 25855807Pakseresht N, Alako B, Amid C, Cerdeño-Tárraga A, Cleland I, Gibson R, Goodgame N, Gur T, Jang M, Kay S, Leinonen R, Li W, Liu X, Lopez R, McWilliam H, Oisel A, Pallreddy S, Plaister S, Radhakrishnan R, Rivière S, Rossello M, Senf A, Silvester N, Smirnov D, Squizzato S, ten Hoopen P, Toribio AL, Vaughan D, Zalunin V, Cochrane G. Assembly information services in the European Nucleotide Archive. Nucleic Acids Res. 2014 Jan;42(Database issue) D38-43. PMID: 24214989McWilliam H, Valentin F, Goujon M, Li W, Narayanasamy M, Martin J, Miyar T, Lopez R. Web services at the European Bioinformatics Institute-2009. Nucleic Acids Res. 2009 Jul;37(Web Server issue) W6-10. PMID: 19435877Gracey AY, Fraser EJ, Li W, Fang Y, Taylor RR, Rogers J, Brass A, Cossins AR. Coping with cold: An integrative, multitissue analysis of the transcriptome of a poikilothermic vertebrate. Proc Natl Acad Sci U S A. 2004 Nov;101(48) 16970-16975. PMID: 15550548Williams DR, Epperson LE, Li W, Hughes MA, Taylor R, Rogers J, Martin SL, Cossins AR, Gracey AY. Seasonally hibernating phenotype assessed through transcript screening. Physiol Genomics. 2005 Dec;24(1) 13-22. PMID: 16249311Gonzalez SF, Chatziandreou N, Nielsen ME, Li W, Rogers J, Taylor R, Santos Y, Cossins A. Cutaneous immune responses in the common carp detected using transcript analysis. Mol Immunol. 2007 Mar;44(7) 1664-1679. PMID: 17049603.