个人简历

“长江学者”特聘教授，国家杰出青年科学基金获得者，中山大学肿瘤防治中心实验研究部副主任，华南肿瘤学国家重点实验室PI。于2003年获德国Bielefeld大学生物化学博士学位。在1998---2008年，一直在美国、德国从事细胞生物学、肿瘤学研究工作。2008年5月，全职回国（中山大学“百人计划”引进人才）；2009年，获国家自然科学基金重点项目、“973”计划项目（课题组组长）；2011年，获国家杰出青年基金、“973”计划项目（学术骨干）；2012年，获国家肝癌重大专项基金（子课题）；2014年, 获”长江学者”特聘教授；2015年，再次获国家自然科学基金重点项目; 2016年，国家重点研发计划“蛋白质机器与生命活动调控”项目（课题组长）。通讯或第一作者在Cancer Cell, J Clin Invest, J Natl Cancer Inst, Cell Res, Nucleic Acids Res，Cancer Res, Clin Cancer Res, Oncogene, J Pathol, J Biol Chem 等国际主流杂志上发表论著35篇。

研究领域

细胞周期调控、肿瘤靶向治疗的基础研究、肿瘤的转移调控等

近期论文

1. Kang T, Wei Y, Chiang Y, Yamaguchi H, Appella E, Hung MC, and Piwnica-Worms H*. GSK-3beta Targets Cdc25A for Ubiquitin-Mediated Proteolysis and GSK-3beta Inactivation Correlates with Cdc25A Overproduction in Human Cancers. Cancer Cell. 13, 36-47, 2008.（IF: 23.21）　　2.Wu Y, Zhou L, Wang X, Lu J, Zhang R, Liang X, Wang L, Deng W, Zeng X-Y, Huang H, Kang T* A genome-scale CRISPR-Cas9 screening method for protein stability reveals novel regulators of Cdc25A. Cell Discovery (Cell Res.姊妹刊), 2，16014, 2016.Research Highlight: Wu Y and Kang T* Protein stability regulators screening assay (Pro-SRSA): protein degradation meets the CRISPR-Cas9 library. Chin J Cancer, 35(1):60. 2016　　3. Xu S#, Wu Y#, Chen Q, Cao J, Hu K, Tang J, Sang Y, Lai F, Wang L, Zhang R, Li S-P, Zeng Y-X, Yin Y, Kang T*. hSSB1 regulates both the stability and the transcriptional activity of p53. Cell Res. 23，423-35，2013.（IF: 14.81）　　4. Hong J#, Hu K#, Yuan Y*, Sang Y, Bu Q, Chen G, Yang L, Li B, Huang P, Chen D1, Liang Y, Zhang R, Pan J, Zeng YX, Kang T*. Chk1 Targets Spleen Tyrosine Kinase (L) for Proteolysis in Hepatocellular Carcinoma. J Clin Invest. 122，2165-75，2012.（IF: 12.57）　　5. Tang QL#, Xie XB#, Wang J#, Chen Q, Han AJ, Zou CY, Yin JQ, Liu DW, Liang Y, Zhao ZQ, Yong BC, Zhang RH, Feng QS, Deng WD, Zhu XF, Zhou BP, Zeng YX1, Shen JN*, and Kang T*. Glycogen Synthase Kinase-3β, NF-κB Signaling, and Tumorigenesis of Osteosarcoma. J Natl Cancer Inst. 104，749-63, 2012.（IF: 11.37）Editorials: Woodgett JR, Can a Two-Faced Kinase be Exploited for Osteosarcoma? J Natl Cancer Inst, 104(10):722-3, 2012　　6. Wu Y#, Chen H#, Lu J, Zhang M, Zhang R, Duan T, Wang X, Huang J*, Kang T*. Acetylation-dependent function of human single-stranded DNA binding protein 1.Nucleic Acids Res. 43(16):7878-87, 2015.（IF: 9.20）　　7. Wang X, Li L, Wu Y, Zhang R, Zhang M, Liao D, Wang G, Qin G, Xu RH, Kang T*.CBX4 suppresses metastasis via recruitment of HDAC3 to the Runx2 promoter in colorectal carcinoma. Cancer Res. 76(24):7277-7289, 2016.（IF: 8.55）　　8. Liao D, Zhong L, Duan T, Zhang RH, Wang X, Wang G, Hu K, Lv X, Kang T*. Aspirin suppresses the growth and metastasis of osteosarcoma through the NF-kB pathway. Clin Cancer Res, 21, 5349-59, 2015.（IF: 8.74）　　9. Xu S#, Feng Z#, Zhang M#, Wu Y, Sang Y, Xu H, Lv X, Hu K, Cao J, Zhang R, Chen L, Liu M, Yun JP, Zeng YX, Kang T*. hSSB1 binds and protects p21 from ubiquitin-mediated degradation and positively correlates with p21 in human hepatocellular carcinomas. Oncogene, 30, 2219-29, 2011.（IF: 7.93）　　10. Wang L#, Sang Y#, Tang J#, Zhang R, Luo D, Chen M, Deng WG, Kang T*. Down-regulation of Prostate stem cell antigen (PSCA) by Slug Promotes Metastasis in Nasopharyngeal Carcinoma. J Pathol, 237, 411-22, 2015.（IF: 7.38）