个人简历

免疫学博士，广东省“珠江学者”特聘教授，中山医学院免疫学教研室主任，国家级基础医学实验教学中心主任，热带病防治研究教育部重点实验室PI，广东省免疫学会常务理事，广东省病毒学专业委员会理事，全国医学院校统编教材《医学微生物学》副主编。1994获中山医科大学与中国预防医学科学院病毒学研究所联合培养博士学位。1994－1996年在美国密歇根大学医学院接受博士后训练，1996－2008年在美国韦恩州立大学医学院先后担任研究科学家、助理教授、副教授（Associate Professor）等职，作为美国NIH R01课题负责人（PI）主持多项抗感染免疫和细胞生物学研究课题，组建和领导抗感染免疫与调控机制研究实验室，在抗感染免疫的病理损害及其分子调控机制、模式识别受体的信号转导与负调控机制研究方面开展了一系列原创性工作。2008年全职回国后，作为课题第一负责人主持国家自然科学基金重点项目、面上项目、国际合作项目、国家重大传染病专项、广东省自然科学基金重点项目、广东省引进创新团队项目、广东省“珠江学者”资助项目等多项基金，总资助金额达3000多万元人民币。

研究领域

黄曦教授致力于抗感染免疫与炎症的信号转导与分子调控机制等前沿领域的研究，探讨模式识别受体（PRR）包括Toll样受体（TLR）、Nod样受体（NLR）、RLH和TREM及PRR负调控分子等天然免疫调控的作用及其机制，阐明细菌性（如：绿脓杆菌、结核分枝杆菌等）和病毒性（如登革热病毒、艾滋病病毒等）疾病的天然免疫调控机制，深入研究病原体感染导致的免疫病理损害机制，为进一步寻找可能的药物作用靶点和防治机制提供科学的理论依据。

近期论文

1) Wang Jinli, Wu Minhao, Wen Jinsheng, Yang Kun, Li Miao, Zhan Xiaoxia, Feng Lianqiang, Li Meiyu* and Huang Xi*. MicroRNA-155 induction by Mycobacterium bovis BCG enhances ROS production through targeting SHIP1.Mol Immunol. 2014 Nov;62(1):29-36. DOI: 10.1016 /j.molimm.2014.05.012. Epub 2014 Jun 14. PMID: 24937178. (IF：3.003) 2) Li Yuye, Wu Siyu, Pu Jieying, Huang Xi and Zhang Ping*.. Dengue Virus Upregulates Expression of Notch Ligands Dll1 and Dll4 Through IFN-β Signaling Pathway. Immunology 2014 Jul 10. DOI: 10.1111/imm.12357. (IF：3.735) 3) Jinli Wang, Chunyu Huang, Minhao Wu, Qiu Zhong, Xiaoxia Zhan, Kun Yang, Lin Zhou* and Xi Huang*. MRP8/14 Induces Autophagy to Eliminate Intracellular Mycobacteria. Journal of Infection, 2014, Accepted. (IF：4.017) 4) Tian GB and Xi Huang*. CTX-M-137, a hybrid of CTX-M-14-like and CTX-M-15-like β-lactamases identified in an Escherichia coli clinical isolate. 2014; 69(8):2081-5. DOI: 10.1093/jac/dku126. Epub 2014 Apr 28. (IF：5.439)1, Huang YM2, Fang ZL2, Qing Y2, Zhang XF1J. Antimicrob Chemother. 5) Kun Yang, Minhao Wu, Meiyu Li, Dandan Li, Anping Peng, Xinxin Nie, Mingxia Sun, Jinli Wang, Yongjian Wu, Qiuchan Deng, Min Zhu, Kang Chen, Jin Yuan and Xi Huang*. miR-155 suppresses bacterial clearance in Pseudomonas aeruginosa keratitis by targeting Rheb. Journal of Infectious Disease, 2014 Jan 7, PMID: 24403554 (IF：5.848) 6) Jinli Wang, Kun Yang, MinhaoWu, Yongjian Wu, Lin Zhou, Tao Chen, Min Zhu, Chunyu Huang, Lianqiang Feng, Meiyu Li, Qiu Zhong* and Xi Huang*. MicroRNA-155 Promotes Autophagy to Eliminate Intracellular Mycobacteria by Targeting Rheb. PLoS Pathogens. 2013; 9(10): e1003697. DOI: 10.1371/journal.ppat.1003697. (IF：8.136) 7) Kun Yang, Jinli Wang, Andy Peng Xiang, Xiaxia Zhan, Yongjian Wu, Minhao Wu* and Xi Huang*. Functional RIG-like receptors control the survival of mesenchymal stem cells. Cell Death and Diseases, 2013 (4) , e967; DOI:10.1038/CDDIS.2013.504 (IF：6.044) 8) Siyu Wu, Li He, Yuye Li, Lianqiang Feng, Minhao Wu, Ping Zhang* and Xi Huang*. microRNA-146a Facilitates the Replication of Dengue Virus Serotype 2 by Damping the Interferon Induction via Targeting TNFR-associated Factor 6. Journal of Infection. 2013 May 16. DOI: S0163-4453(13)00112-6. 10.1016/j.jinf.2013.05.003. (IF：4.073) 9) Kang Chen, Lin Yin, Xinxin Nie , Qiuchan Deng, Yongjian Wu, Min Zhu, Dandan Li, Meiyu Li, Minhao Wu* and Xi Huang*. Beta-catenin promotes host resistance against Pseudomonas aeruginosa keratitis. Journal of Infection. 2013; 67(6): 584-594, DOI: 10.1016/j.jinf.2013. 07.025. (IF：4.073) 10) Zhang Peifen, Li Yuye, Xia Jun, He Junfang, Pu Jieying, Xie Jiong, Wu Siyu, Feng Lianqiang, Huang Xi and Zhang Ping*. IPS-1 plays an essential role in dsRNA-induced stress granule formation by interacting with PKR and promoting its activation.. 2014 Jun 1; 127(Pt 11):2471-82. DOI: 10.1242/jcs.139626. Epub 2014 Mar 21.PMID: 24659800. (IF：5.877) J Cell Sci 11) Mingxia Sun, Min Zhu , Kang Chen ,Xinxin Nie, Qiuchan Deng, Linda D. Hazlett, Yongjian Wu, Meiyu Li, Minhao Wu* and Xi Huang*. TREM-2 Promotes Host Resistance against Pseudomonas aeruginosa Infection by Suppressing Corneal Inflammation via a PI3K/Akt Signaling Pathway. Invest Ophthalmol Vis Sci. 2013 May 17; 54(5):3451-3462. DOI: 10.1167. (IF：3.441) 12) Qiuchan Deng, Mingxia Sun, Kun Yang, Jin Yuan, Minhao Wu*, Huang X*. MRP8/14 Enhances Corneal Susceptibility to Pseudomonas aeruginosa Infection by Amplifying Inflammatory Responses. Invest Ophthalmol Vis Sci. 2013; 54(2):1227-1234 (IF：3.441) 13) Yuye Li, Jiong Xie, Siyu Wu, Jun Xia, Peifen Zhang, Chao Liu, Ping Zhang*, Xi Huang*. Protein Kinase Regulated by dsRNA Downregulates the Interferon Production in Dengue Virus- and dsRNA-stimulated Human Lung Epithelial Cells. PLoS One. 2013; 8(1):e55108. DOI: 10.1371/ journal.pone.0055108. (IF：3.73) 14) Yun Qing, Kai-yuan Cao, Zhi-li Fang, Ying-min Huang, Xue-fei Zhang, Guo-bao Tian*, and Xi Huang*. Outbreak of PER-1 and Diversity of β-Lactamases among Ceftazidime- Resistant Pseudomonas aeruginosa Clinical Isolates in China. Journal of Medical Microbiology. 2014; 63:386-392. doi: 10.1099/jmm.0.069427-0. Epub 2014 Jan 7. PMID: 24398232 (IF：2.297) 15) Zhi-li Fang; Li-yan Zhang; Ying-min Huang; Yun Qing; Kai-yuan Cao; Guo-bao Tian*; Xi Huang*. OprD mutations and inactivation in imipenem-resistant Pseudomonas aeruginosa isolates from China. Infection, Genetics and Evolution, 2014 Jan; 21:124-128. DOI: 10.1016 /j.meegid.2013.10.027. Epub 2013 Nov 8. PMID: 24211415 (IF：2.768) 16) Ping Zhang, Siyu Wu, Siyu Wu, Lietao Li, Zhaoduan Liang , Yuye Li, Lianqiang Feng, Xi Huang*. Adjuvant PIKA protects hepatoma cells from dengue virus infection by promoting TBK-1 dependent innate immune response. Arch. Virol. 2013, DOI 10.1007/s00705-012 -1556-8 (IF：2.03) 17) Minhao Wu, Anping Peng, Mingxia Sun, Qiuchan Deng, Linda D. Hazlett, Jin Yuan, Xialin Liu, Qianying Gao, Lianqiang Feng, Junfang He, Ping Zhang* and Xi Huang*. TREM-1 Amplifies Corneal Inflammation after P. aeruginosa Infection by Modulating TLR Signaling and Th1-/Th2-type Immune Responses. Infection and Immunity. 2011; 79(7): 2709-2716. (IF：4.165) 18) Zhaoduan Liang, Siyu Wu, Yuye Li, Li He, Minhao Wu, Lifang Jiang, Lianqiang Feng, Ping Zhang*, and Xi Huang*, Activation of Toll-like receptor 3 Impairs the Dengue Virus Serotype 2 Replication Through Induction of IFN-b in Cultured Hepatoma Cells. PloS One. 2011; 6(8):e23346. (IF：4.092) 19) Min Zhu, Dandan Li, Yongjian Wu, Xi Huang and Minhao Wu*. TREM-2 promotes macrophage-mediated eradication of Pseudomonas aeruginosa via a PI3K/Akt pathway. Scandinavian Journal of Immunology, 2014 Jan 2. DOI: 10.1111/sji.12148. PMID: 24383713 (IF：2.199) 20) Chen K, Wu Y, Zhu M, Deng Q, Nie X, Li M, Wu M and Xi Huang*. Lithium chloride promotes host resistance against Pseudomonas aeruginosa keratitis. Mol Vis. 2013 Jul 19; 19:1502-1514. PMID: 23878501. (IF：2.511)