个人简历

龚畅，外科学博士，中山大学孙逸仙纪念医院乳腺肿瘤医学部乳腺外科副教授、副主任医师，博士研究生导师。入选教育部新世纪优秀人才、广东省自然科学杰出青年和广州市珠江科技新星等人才项目。2009年至2010年获中法合作交流项目（PFCC PHC）资助赴法国巴黎国家卫生研究院（INSERM）进行博士后研究，2016年至2017年国家留学基金委(CSC公派至英国卡迪夫大学进行乳腺癌相关的基础和临床研究。

研究领域

1）表观遗传（侧重非编码RNA、组蛋白修饰肿瘤转移和耐药的分子机制；2）肿瘤的自噬调控机制； 3）Biomarker（分子标记物）临床预测肿瘤预后和疗效。

近期论文

1. Chen J#, Yao Y#, Gong C#, Yu F#, Sun S, Chen J, Liu B, Deng H, Wang F, Lin L, Yao H, Sun F, Karen S. Anderson, Liu Q, Mark E. Ewen, Yao X*, Song E*. CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3. Cancer Cell 2011 Apr 12; 19 (4):541-55. 2. Gong C#, Yao Y, Wang Y, Liu B, Wu W, Chen J, Su F, Yao H*, Song E*. Upregulation of MIR-21 mediates resistance to trastuzumab therapy for breast cancer. Journal of Biological Chemistry 2011 May 27; 286(21):19127-37. 3. Gong C, Song E, Codogno P, Mehrpour M.The roles of BECN1 and autophagy in cancer are context dependent. Autophagy. 2012 Dec; 8(12):1853-5. 4. Nie Y, Liu X, Qu S, Song E, Zou H*, Gong C*. Long noncoding RNA HOTAIR is an independent prognostic marker for nasopharyngeal carcinoma progression and survival. Cancer Science. 2013 Apr; 104(4):458-64. 5. Gong C, Bauvy C, Tonelli G, Yue W, Delome′nie C, Nicolas V, Zhu Y, Domergue V, Marin-Esteban V, Tharinger H, Delbos L, Gary-Gouy H, Morel A-P, Ghavami S, Song E*, Codogno P* and Mehrpour M*. Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells. Oncogene. 2013 May 2; 32(18):2261-72. 6. Li H#, Chen K#, Su F, Song E, Gong C*. Preoperative CA 15-3 levels predict the prognosis of nonmetastatic luminal A breast cancer. Journal of Surgical Research. 2014 Jun 1; 189(1):48-56. 7. Gong C#, Nie Y#, Qu S, Liao J, Cui X, Yao H, Zeng Y, Su F, Song E#, Liu Q#. miR-21 induces myofibroblast differentiation and promotes the malignant progression of breast phyllodes tumors. Cancer Research. 2014 Aug 15; 74(16):4341-52. 8. Gong C#, Qu S#, Lv X#, Liu B, Tan W, Nie Y, Su F, Liu Q*, Yao H*, Song E*. BRMS1L suppresses breast cancer metastasis by inducing epigenetic silence of FZD10. Nature Communications. 2014 Nov 19; 5:5406. 9. Gong C#,Qu S#, Liu B#,Pan S,Jiao Y,Nie Y, Su F,Liu Q*,Song E*. MiR-106b expression determines the proliferation paradox of TGF-β in breast cancer cells. Oncogene 2015 Jan 2; 34(1):84-93. 10. Liu B# , Sun L# , Liu Q#, Gong C#, Yao Y , Lv X, Lin L, Yao H , Su F , Li D , Zeng M , Song E. A Cytoplasmic NFκB Interacting Long Noncoding RNA Blocks IκB Phosphorylation and Suppresses Breast Cancer Metastasis. Cancer Cell. 2015 Mar 9; 27(3):370-81. 11. Gong C#, Liu B#, Yao Y#, Qu S, Luo W, Tan W, Liu Q, Yao H, Zou L, Su F*, Song E*. Potentiated DNA Damage Response in Circulating Breast Tumor Cells Confers Resistance to Chemotherapy. J Biol Chem. 2015 Jun 12; 290(24):14811-25.