个人简历

雅彬，博士，研究员，毕业于北京协和医学院，现为中山大学孙逸仙纪念医院生物化学与分子生物学博士生导师

研究领域

癌症生物学、基因组学、生物信息学

近期论文

1. Guo Y, Updegraff BL, Park S, Durakoglugil D, Burton V, Maddux S, Hwang TH, O’Donnell KA. Comprehensive ex vivo transposon mutagenesis identifies novel drivers of human leukemogenesis. Cancer Research 2016 Feb 15;76(4):773-786 （Epub ahead of print）（IF: 9.33） 2. Guo Y, Singh P, Levin HL. A long terminal repeat retrotransposon of Schizosaccharomyces japonicus integrates upstream of RNA pol III transcribed genes. Mobile DNA 2015 Oct 9; 6 (1):19. (IF: 2.11) 3. Chatterjee AG, Esnault C, Guo Y, Hung S, McQueen PG, Levin HL. Serial number tagging reveals a prominent sequence preference of retrotransposon integration. Nucleic Acids Research. 2014 Sep 1;42(13):8449-60. (IF: 9.11) 4. Guo Y, Park JM, Cui B, Humes E, Gangadharan S, Hung S, FitzGerald PC, Hoe KL, Grewal SI, Craig NL, Levin HL. Integration profiling of gene function with dense maps of transposon integration. Genetics. 2013 Oct;195(2):599-609. (IF: 5.96) 5. Rhind N, Chen Z, Yassour M, Thompson DA, Haas BJ, Habib N, Wapinski I, Roy S, Lin MF, Heiman DI, Young SK, Furuya K, Guo Y, Pidoux A, Chen HM, Robbertse B, Goldberg JM, Aoki K, Bayne EH, Berlin AM, Desjardins CA, Dobbs E, Dukaj L, Fan L, FitzGerald MG, French C, Gujja S, Hansen K, Keifenheim D, Levin JZ, Mosher RA, Müller CA, Pfiffner J, Priest M, Russ C, Smialowska A, Swoboda P, Sykes SM, Vaughn M, Vengrova S, Yoder R, Zeng Q, Allshire R, Baulcombe D, Birren BW, Brown W, Ekwall K, Kellis M, Leatherwood J, Levin H, Margalit H, Martienssen R, Nieduszynski CA, Spatafora JW, Friedman N, Dalgaard JZ, Baumann P, Niki H, Regev A, Nusbaum C. Comparative functional genomics of the fission yeasts. Science 2011 May:20;332(6032):930-6. (IF: 33.61) 6. Guo Y, Levin HL. High-throughput sequencing of retrotransposon integration provides a saturated profile of target activity in Schizosaccharomyces pombe. Genome Research. 2010 Feb;20(2):239-48. Epub 2009 Dec 29. (IF: 14.63) 7. 陈凤、郭雅彬、刘士廉、郑德先、刘彦信。抗肿瘤坏死因子相关凋亡诱导配体受体死亡受体5嵌合抗体的构建及其真核表达。中国医学科学院学报 2008 Dec;30(6):690-5. (IF: N/A) 8. Shi J, Liu Y, Zheng Y, Guo Y, Zhang J, Cheung PT, Xu R and Zheng D. Therapeutic expression of an anti-death receptor 5 single-chain fixed-variable region prevents tumor growth in mice. Cancer Research. 2006 Dec 15; 66(24): 11946-53. (IF: 9.33) 9. Guo Y, Chen C, Zheng Y, Zhang J, Tao X, Liu S, Zheng D and Liu Y. A novel anti-human DR5 monoclonal antibody with tumoricidal activity induces caspase-dependent and caspase-independent cell death. J. Biol. Chem. 2005 Dec 23;280(51):41940-52. Epub 2005 Oct 18. (IF: 4.6)