个人简历

本科毕业于厦门大学生物技术专业，博士毕业于复旦大学遗传学专业。先后在美国明尼苏达大学、纽约州立大学石溪分校等地从事博士后研究工作。中山大学“百人计划”引进人才，现任肿瘤防治中心（附属肿瘤医院）研究员、博士生导师。在Nature Cell Biology等SCI杂志上发表第一作者及通讯作者论文十余篇，并获得国家自然科学基金、国家重点基础研究发展计划（973）、重大新药创制等经费的资助

研究领域

1、炎症及生长因子信号与癌变； 2、抗肿瘤、抗病毒免疫。

近期论文

　1、 Chen S, Bohrer L, Rai A, Pan Y, Gan L, Zhou X, Bagchi A, Simon JA, Huang H. Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2. Nat Cell Biol 2010 Nov; 12(11):1108-14. (selected by Faculty of 1000)　2、 Wang L#, Zeng X#, Chen S#, Ding L, Zhong J, Zhao JC, Sarver A, Koller A, Zhi J, Ma Y, Yu J, Chen J, Huang H. BRCA1 is a negative modulator of the PRC2 complex. EMBO J. 2013 May 29;32(11):1584-97. (selected by Faculty of 1000)　3、 Chen S, Sheng C, Liu D, Yao C, Gao S, Song L, Jiang W, Li J, Huang W. Enhancer of zeste homolog 2 is a negative regulator of mitochondria-mediated innate immune responses. J Immunol. 2013 Sep 1;191(5):2614-23.　4、 Ding L#, Chen S#, Liu P, Pan Y, Zhong J, Regan KM, Wang L, Yu C, Rizzardi T, Cheng L, Zhang J, Schmechel SC, Cheville JC, van Deursen J, Tindall DJ, Huang H. CBP loss cooperates with PTEN haploinsufficiency to drive prostate cancer: implications for epigenetic therapy. Cancer Res. 2014 Apr 1;74(7):2050-61.　5、 Gao S, Wu J, Liu RY, Li J, Song L, Teng Y, Sheng C, Liu D, Yao C, Chen H, Jiang W, Chen S*, Huang W*. Interaction of NS2 with AIMP2 facilitates the switch from ubiquitination to SUMOylation of M1 in influenza A virus-infected cells. J Virol. 2015 Jan;89(1):300-11.　6、 Chen H, Gao S, Li J, Liu D, Sheng C, Yao C, Jiang W, Wu J, Chen S*, Huang W*. Wedelolactone disrupts the interaction of EZH2-EED complex and inhibits PRC2-dependent cancer. Oncotarget. 2015 May 30;6(15):13049-59.　7、 Liu D, Sheng C, Gao S, Yao C, Li J, Jiang W, Chen H, Wu J, Pan C, Chen S*, Huang W*. SOCS3 Drives Proteasomal Degradation of TBK1 and Negatively Regulates Antiviral Innate Immunity. Mol Cell Biol. 2015 Jul 15;35(14):2400-13.