个人简历

2007年于武汉大学生命科学学院获得学士学位；2013年于中国科学院生物物理研究所获得分子生物学与生物化学博士学位；2013年7月至2018年在加拿大蒙特利尔临床研究所(Montreal Clinical Research Institute)从事博士后研究工作，导师为加拿大皇家科学院院士, 国际著名分子免疫学家 André Veillette教授。

研究领域

主要研究兴趣为巨噬细胞相关的肿瘤免疫。主要研究方向包括：（1） SIRPa-CD47免疫检查点通路在肿瘤免疫治疗中的研究和应用；（2）巨噬细胞上新型免疫检查点通路的发现；（3）肿瘤微环境中巨噬细胞的功能研究等。

近期论文

1. Chen J, Zhong MC, Guo H, Davidson D, Mishel S, Lu Y, Rhee I, Pérez-Quintero LA, Zhang S, Cruz-Munoz ME, Wu N, Vinh DC, Sinha M, Calderon V, Lowell CA, Danska JS, Veillette A. SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin. Nature544, 493-497. (2017). Highlighted by: Science Signaling, Cancer Discovery, Cancer Immunology Research. 2. Guo H, Cranert SA, Lu Y, Zhong MC, Zhang S, Chen J, Li R, Mahl SE, Wu N, Davidson D, Waggoner SN, Veillette A. Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1. The Journal of Experimental Medicine. 2016, 213(10):2187-207. 3. Chen J*, Hao L*, Li C, Ye B, Du Y, Zhang H, Long B, Zhu P, Liu B, Yang L, Li P, Tian Y, Fan Z. The Endoplasmic Reticulum Adaptor Protein ERAdP Initiates NK Cell Activation via the Ubc13-Mediated NF-kB Pathway. The Journal of Immunology. 2015, 194,1292-1303. (*equally contributing authors) 4. Li C, Yang Z, Du Y, Tang H, Chen J, Hu D, Fan Z. BCMab1, A Monoclonal Antibody against Aberrantly Glycosylated Integrin α3β1, Has Potent Antitumor Activity of Bladder Cancer In Vivo. Clinical Cancer Research. 2014, 20(15): 4001-4013. 5. Li M, Xia P, Du Y, Liu S, Huang G, Chen J, Zhang H, Hou N, Cheng X, Zhou L, Li P, Yang X, Fan Z.T-cell Immunoglobulin and ITIM Domain (TIGIT) Receptor/Poliovirus Receptor (PVR) Ligand Engagement Suppresses Interferon-γ Production of Natural Killer Cells via β-Arrestin 2-mediated Negative Signaling. Journal of Biological Chemistry. 2014, 289(25): 17647-17657. 6. Qu Q, Chen J, Wang Y, Gui W, Wang L, Fan Z, Jiang T. Structural insights into the allosteric activation mechanism of p75NTR. PLoS One2013, 8(3):e57839. 7. Guo Y*, Chen J*, Shi L, Fan Z. Valosin-containing protein cleavage by granzyme K accelerates an endoplasmic reticulum stress leading to caspase-independent cytotoxicity of target tumor cells. Journal of Immunology. 2010, 185(9): 5348-5359. (*equally contributing authors). 8. Guo Y, Chen J, Zhao T, Fan Z. Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity. Molecular Immunology. 2008, 45(8): 2225-2235.