个人简历

医学博士、教授、博士生导师。1977年开始从事组织学与胚胎学专业。1980年攻读中山医学院硕士研究生，探讨神经生长因子促进神经元突起生长机制。1988年攻读华西医科大学(现四川大学)博士研究生,研究吗啡对脊髓可塑性的影响。1998年在美国印第安纳州大学医学院做博士后研究，探讨全脑缺血后神经元凋亡机制。回国后，研究干细胞移植与脊髓损伤修复机制。2003年在香港大学医学院做访问学者，研究成体干细胞的分化。聘任为中山大学中山医学院组织胚胎学教研室教授、教研室主任(2003-2018)、中山大学脊髓损伤研究所副所长、中山大学干细胞与组织工程教育部重点实验室副主任、广东省脑功能与脑疾病重点实验室副主任、中国解剖学会常务理事、广东省解剖学会理事长(2007-2016)、广东省人体生物组织工程学会副理事长、广东省细胞生物学会副理事长、江苏省神经再生协同创新中心核心成员、四川省干细胞应用研究中心重点实验室学术委员会委员、河南省高等学校组织再生重点开放实验室学术委员会委员、解剖学研究杂志副主编。获国务院特殊津贴专家荣誉。培养和指导博士生30名、硕士生31名、博士后4名、特聘研究员2名和特聘副研究员2名。

研究领域

研究团队一直从事脊髓可塑性、干细胞移植与脊髓损伤修复、组织工程神经网络修复脊髓损伤和电针联合干细胞移植修复脊髓损伤等研究，并取得如下主要学术成果：1.) 首先发现吗啡可以促进备用根初级传入纤维在脊髓内侧支出芽，并与失去初级传入纤维支配的靶神经元重建突触联系; 备用根背根节神经元发出的初级传入纤维侧支出芽在脊髓内重建突触结构后，其胞体亦发生相应的可塑性变化，吗啡对这些变化有明显的促进作用; 这些可塑变化与吗啡促进脊髓内神经营养活性物质分泌有关。2.) 将神经营养素-3(NT-3)基因修饰雪旺细胞与NT-3受体(TrkC)基因修饰神经干细胞(NSCs)或骨髓间充质干细胞(MSCs)联合移植到全横断脊髓损伤处，能够促进NSCs或MSCs分化为NSC或MSC源性神经元，替换因损伤而死亡的宿主神经元。同时，更好地保护受损伤的脊髓背核、中脑红核和大脑皮质神经元存活，促进其轴突再生、重建突触和髓鞘形成。其脊髓神经传导功能如皮质运动诱发电位和感觉诱发电位有一定程度的恢复，瘫痪的后肢自主运动得到改善。3.) 在体外成功构建了一种具有突触传递功能的NSC或MSC源性神经网络组织，将其移植到脊髓损伤处，可与宿主神经网络整合，并改善受损伤脊髓的功能。4.) 率先应用电针督脉穴刺激全横断脊髓损伤或脊髓脱髓鞘损伤的脊膜支传入神经纤维将信息传入脊髓，激活脊髓组织细胞合成和分泌NT-3，介导表达TrkC的外源性NSCs和MSCs在全横断脊髓损伤/移植处或脊髓脱髓鞘损伤/移植处存活、分化和迁移，在改善受损伤组织微环境的同时替换和保护受损伤的宿主神经元、促进轴突再生及其髓鞘形成、改善皮层运动诱发电位以及瘫痪肢体的运动功能。

近期论文

Jin H, Zhang YT, Yang Y, Wen LY, Wang JH, Xu HY, Lai BQ, Feng B, Che MT, Qiu XC, Li ZL, Wang LJ, Ruan JW, Jiang B, Zeng X, Deng QW, Li G, Ding Y*, Zeng YS*. Electroacupuncture facilitates the integration of neural stem cell-derived neural network with transected rat spinal cord. Stem Cell Reports, 2019, 2:1-16. Wu GH, Shi HJ, Che MT, Huang MY, Wei QS, Feng B, Ma YH, Wang LJ, Jiang B, Wang YQ, Han I, Ling EA, Zeng X*, Zeng YS*. Recovery of paralyzed limb motor function in canine with complete spinal cord injury following implantation of MSC-derived neural network tissue. Biomaterials, 2018, 181:15-34. Lai BQ, Feng B, Che MT, Wang LJ, Cai S, Huang MY, Gu HY, Jiang B, Ling EA, Li M, Zeng X*, Zeng YS*. A modular assembly of spinal cord-like tissue endows targeted tissue repair in the transected spinal cord. Advanced Science, 2018, 5(9):1800261(1 of 14). Li G, Che MT, Zeng X, Qiu CX, Feng B, Lai BQ, Shen HY, Ling EA, Zeng YS*. Neurotrophin-3 released from implant of tissue-engineered fibroin scaffolds inhibits inflammation, enhances nerve fiber regeneration and improves motor function in canine spinal cord injury. J Biomed Mater Res A, 2018, 106(8):2158-2170. Ma YH, Zeng X*, Qiu XC, Wei QS, Che MT, Ding Y, Liu Z, Wu GH, Sun JH, Pang M, Rong LM, Liu B, Aljuboori Z, Han I, Ling EA, Zeng YS*. Perineurium-like sheath derived from long-term surviving mesenchymal stem cells confers nerve protection to the injured spinal cord. Biomaterials, 2018, 160:37-55. Zou JL, Liu S, Sun JH, Yang WH, Xu YW, Rao ZL, Jiang B, Zhu QT, Liu XL, Wu JL, Chang C, Mao HQ, Ling EA, Quan DP*, Zeng YS*. Peripheral nerve-derived matrix hydrogel promotes remyelination and inhibits synapse formation. Advanced Functional Materials, 2018, 1705739 (1 of 12). Wang JM, Qu ZQ, Wu JL, Chung P, Zeng YS*. Mitochondrial protective and anti-apoptosis effects of Rhodiola Crenulata extract on hippocampal neurons in a rat model of Alzheimer’s disease. Neural Regen Res, 2017, 12(12):2025-2034. Zhang YT, Jin H, Wang JH, Wen LY, Yang Y, Ruan JW, Zhang SX, Ling EA, Ding Y*, Zeng YS*. Tail nerve electrical stimulation and electro-acupuncture can protect spinal motor neurons and alleviate muscle atrophy after spinal cord transection in rats. Neural Plast, 2017, 2017:7351238 (1 of 11). Yang XH, Ding Y, Li W, Zhang RY, Wu JL, Ling EA, Wu W, Zeng YS*. Effects of electroacupuncture and the RXR signaling pathway on oligodendrocyte differentiation in the demyelinated spinal cord of rats. Acupunct Med, 2017, 35(2):122-132. Lai BQ, Che MT, Du BL, Zeng X, Ma YM, Feng B, Qiu XC, Zhang K, Liu S, Shen HY, Wu JL, Ling EA, Zeng YS*. Transplantation of tissue engineering neural network and formation of neuronal relay into the transected rat spinal cord. Biomaterials, 2016, 109:40-54. Lin XY, Lai BQ, Zeng X, Che MT, Ling EA, Wu W, Zeng YS*. Cell transplantation and neuroengineering approach for spinal cord injury treatment: A summary of current laboratory findings and review of literature (an invited review). Cell Transplant, 2016, 25(8):1425-1438. Zeng X, Ma YH, Chen YF, Qiu XC, Wu JL, Ling EA, Zeng YS*. Autocrine fibronectin from differentiating mesenchymal stem cells induces the neurite elongation in vitro and promotes nerve fiber regeneration in transected spinal cord injury. J Biomed Mater Res A, 2016, 104(8):1902-1911. Li G, Che MT, Zhang K, Qin LN, Zhang YT, Chen RQ, Rong LM, Liu S, Ding Y, Shen HY, Long SM, Wu JL, Ling EA, Zeng YS*. Graft of the NT-3 persistent delivery gelatin sponge scaffold promotes axon regeneration, attenuates inflammation, and induces cell migration in rat and canine with spinal cord injury. Biomaterials, 2016, 83:233-248. Lai BQ, Qiu XC, Zhang K, Zhang RY, Jin H, Li G, Shen HY, Wu JL, Ling EA, Zeng YS*. Cholera toxin B subunit shows transneuronal tracing after injection in an injured sciatic nerve. PLoS One, 2015, 10(12):e0144030 (1 of 13). Qiu XC, Jin H, Zhang RY, Ding Y, Zeng X, Lai BQ, Ling EA, Wu JL, Zeng YS*. Donor mesenchymal stem cell-derived neural-like cells transdifferentiate into myelin-forming cells and promote axon regeneration in rat spinal cord transection. Stem Cell Res Ther, 2015, 6(1):105 (1 of 17). Zou J, Hu B, Arpag S, Yan Q, Hamilton A, Zeng YS, Vanoye CG, Li J. Reactivation of lysosomal Ca2+ efflux rescues abnormal lysosomal storage in FIG4-deficient cells. J Neurosci, 2015, 35(17):6801-6812. Ding Y, Zhang RY, He B, Liu Z, Zhang K, Ruan JW*, Ling EA, Wu JL, Zeng YS*. Combination of electroacupuncture and grafted mesenchymal stem cells overexpressing TrkC improves remyelination and function in demyelinated spinal cord of rats. Scientific Reports, 2015, 5:9133 (1 of 14). Zeng X, Qiu XC, Ma YH, Duan JJ, Chen YF, Gu HY, Wang JM, Ling EA, Wu JL, Wu WT, Zeng YS*. Integration of donor mesenchymal stem cell-derived neuron-like cells into host neural network after rat spinal cord transection. Biomaterials, 2015, 53:184-201. Du BL, Zeng X, Ma YH, Lai BQ, Wang JM, Ling EA, Wu JL, Zeng YS*. Graft of the gelatin sponge scaffold containing genetically modified neural stem cells promotes cell differentiation, axon regeneration and functional recovery in rat with spinal cord transection. J Biomed Mater Res A, 2015, 103(4):1533-1545. Liu Z, He B, Zhang RY, Zhang K, Ding Y, Ruan JW, Ling EA, Wu JL, Zeng YS*. Electroacupuncture promotes the differentiation of transplanted bone marrow mesenchymal stem cells pre-induced with neurotrophin-3 and retinoic acid into oligodendrocyte-like cells in demyelinated spinal cord of rats. Cell Transplant, 2015, 24(7):1265-1281.