个人简历
教育经历2013/06-2014/06，俄亥俄州立大学，肿瘤生理学，访问学者，导师：Ching-Shin Chen 2002/09-2005/08, 中国协和医科大学，生药学专业，博士，导师：杨世林1996/09-1999/07，西北农林科技大学，植物学专业，硕士：导师：傅建熙1992/09-1996/07，石河子大学，栽培学专业，本科，导师：孙杰工作经历2005/08-2007/07,浙江大学,药学院，师资博士后2007/08-2008/07,浙江大学,生物医学工程与仪器科学学院，师资博士后2008/08-2008/12,浙江大学,生物医学工程与仪器科学学院，讲师2009/01-2015/12,浙江大学,生物医学工程与仪器科学学院，副教授2015/12-2019/01,浙江大学,生物医学工程与仪器科学学院，教授2019/01-至今, 浙江理工大学, 生命科学与医药学院，教授
研究领域
主要研究方向为天然产物的提取工艺及功能活性研究（涵盖中药创新药物研发、保健品、天然色素、天然抗氧化剂及防腐剂的研究开发）
近期论文
Han HT, Xu B, Amin A, Li HL, Yu XY, Gong MH, Zhang L*. Quercetin-3-O-a-L-rhamnopyranoside derived from the leaves of Lindera aggregata (Sims) Kosterm. Evokes the autophagy-induced nuclear factor erythroid 2-related factor 2 antioxidant pathway in human umbilical vein endothelial cells. International journal of molecular medicine, 2018, 43(1):461-474.Chen LL#, Han HT#, Amin# A, Zhang L*, Ma SL*. Hydrolysis product of Nigella A obtained from Nigella glandulifera Freyn seeds promotes apoptosis and AMPK-mediated autophagy in human colon cancer SW620 cells. Archives of Biological Sciences, 2018, 70(4):603-612.Zhu W, Xu XB, Tian JK, Zhang L *, Komatsu S*. Proteomic Analysis of Lonicera japonica Thunb. Immature Flower Buds Using Combinatorial Peptide Ligand Libraries and Polyethylene Glycol Fractionation. Journal of Proteome Research, 2016, 15 :166-181.Yang BX, Feng X, Xu JK, Lei HX, Zhang L*.Multi-Component HPLC Analysis and Antioxidant Activity Characterization of Extracts from Dipsacus sativus (Linn.) Honck. International Journal of Food Properties, 2016, 19 :1000-1006.Cheng ZZ, Zhou X, Li WY, Hu BY, Zhang Y, Xu Y, Zhang L*, Jiang HL*.Optimization of solid-phase extraction and liquid chromatography-tandem mass spectrometry for simultaneous determination of capilliposide B and its active metabolite in rat urine and feces: Overcoming nonspecific binding.Journal of Pharmaceutical and BiomedicalAnalysis,2016, 131: 6-12.Yang Y, Zhang LH, Yang BX, Tian JK, Zhang L*. Aurantiamide acetate suppresses the growth of malignant gliomas in vitro and in vivo through activating autophagy. Journal of Cellular and Molecular Medicine. 2015, 19(5): 1055-1064. Xu CJ, Yang BX, Zhu W, Li XM, Tian JK, Zhang L*. Characterization of polyphenol constituents in leaves of Linderae aggregate and their antioxidant activities. Food Chemistry. 2015, 186: 83-89.Zhang YZ, Ma J, Yang BX, Li RY, Zhu W, Sun LL, Tian JK, Zhang L*. The complete chloroplast genome sequence of Taxus chinensis var. mairei (Taxaceae): loss of an inverted repeat region and comparative analysis with related species. Gene，2014, 540(2): 201-209.Hu XJ, Liu XB, Gong MH, Luan M, Zheng YL, Wu GL, Shentu JZ, Zhang L*. Development and validation of liquid chromatography tandem mass spectrometry method for quantification of a potential anticancer triterpene saponin from seeds of Nigella glanduliferain rat plasma: Application to a pharmacokinetic study. Journal of Chromatography B. 2014, 967:156-161.Li RY, Zhang LL, Zhang LJ, Chen D, Tian JK, Cao L, Zhang L*. Capilliposide C derived from Lysimachia capillipes Hemsl inhibits growth of human prostate cancer PC3 cells by targeting caspase and MAPK pathways. International Urology and Nephrology. 2014, 46(7): 1335-1344.Zhang L#, Zhu W#, Zhang YZ, Yang BX, Fu ZR, Li XM, Tian JK. Proteomics analysis of Mahonia bealei leaves with induction of alkaloids via combinatorial peptide ligand libraries. Journal of Proteomics. 2014, 110: 59-71.Zhang L, Li RY, Li MZ, Qi ZJ, Tian JK. In vitro and in vivo study of anti-tuberculosis effect of extracts isolated from Ranunculi Ternati Radix. Sarcoidosis Vasculitis and DiffuseLung Diseases. 2014, 31(4): 336-34. Li WT, Yang BX, Zhu W, Gong MH, Xu XD, Lu XH,Sun LL, Tian JK, Zhang L*. A new indole alkaloidal glucoside from the aerial parts of Clematis terniflora DC. Natural Product Research. 2013, 27(24): 2333-2337.Sun LL, Luan M, Zhu W, Gao S, Zhang QL, Xu CJ, Lu XH, Xu XD, Tian JK, Zhang L*. Study on antitubercular constituents from the seeds of Nigella glandulifera. Chemical & Pharmaceutical Bulletin. 2013, 61(8): 873-876.Zhang L#, Li XM#, Zheng W, Fu ZR, Li WT, Ma LY, Li K, Sun LL, Tian JK. Proteomics analysis of UV-irradiated Lonicera japonica Thunb. with bioactive metabolites enhancement. Proteomics. 2013, 13(23-24): 3508-3522.Ning W, Peng X, Ma LY, Cui L, Lu XP, Wang J, Tian JK, Li XM, Wang W, Zhang L*. Enhanced secondary metabolites production and antioxidant activity in postharvest Lonicera japonica Thunb. in response to UV radiation. Innovative Food Science & Emerging Technologies. 2012,13:231-243.Chen RZ, Cui L, Guo YJ, Rong YM, Lu XH, Sun MY, Zhang L*, Tian JK*. Invivo study of four preparative extracts of Clematis terniflora DC.for antinociceptive activity and anti-inflammatory activity in rat model of carrageenan-induced chronic non-bacterial prostatitis. Journal of Ethnopharmacology. 2011, 134(3): 018-1023.Zhang L, Liu JY, Xu LZ, Yang SL. Chantriolide C, a New Withanolide Glucoside and a New Spirostanol Saponin from the Rhizomes of Tacca chantrieri. Chemical Pharmaceutical Bulletin, 2009, 57(10): 1126-1128.Zhang L, Liu ZH, Tian JK. Cytotoxic Triterpenoid Saponins from the Roots of Platycodon grandiflorum. Molecules, 2007, 12: 832-841.Zhang L, Tian JK, Xu LZ. One new Triterpenoid Saponin from Lysimachia davurica. Natural Products Research, 2007, 21(2):106-110.
