个人简历

高等教育
2000/09 – 2005/06，美国俄勒冈州立大学(Oregon State University)，药学院，海洋天然产物及药物化学，博士
导师：William H. Gerwick 教授
课题：海洋蓝藻的抗癌次生代谢物的化学研究
1996/10 –1999/12, 美国加州州立大学(California State University, Northridge)，有机化学，硕士
1990/09 – 1994/06，杭州大学，生物化学与微生物学，本科
工作简历
2017/01 – 至今，浙江理工大学生命科学学院，研究员，特聘教授，博导
2013/03 – 2016/12, 上海交通大学医学院附属仁济医院，研究员
2010/10 – 2013/02, 浙江大学，海洋科学与工程学系, 副研究员
2010/10 – 2012/07, 美国普渡大学，药学院，访问教授（visiting assistant professor）
2008/03 – 2010/05, 美国国立癌症研究院(NCI), 研究员（research scientist）
2007/10 – 2008/02, 美国普渡大学，药学院，资深博士后（senior postdoctor）
2005/07 – 2007/09, 美国俄勒冈州立大学，质谱分析中心, 博士后

研究领域

主要从事海洋活性天然产物的发现及作用机制研究,聚焦于海洋蓝藻毒素的化学及生物学研究。

近期论文

Xu, L., Ye, K. X., Dai, W. H., Sun, C., Xu, L. H., & Han, B. N. (2019). Comparative Genomic Insights into Secondary Metabolism Biosynthetic Gene Cluster Distributions of Marine Streptomyces. Mar Drugs, 17(9). doi:10.3390/md17090498
Tang Y-H, Liang T-T, Fan T-T, Keen L J, Zhang X-D, Xu L, Zhao Q, Zeng R, Han B-N*. Neo-debromoaplysiatoxin C, with new structural rearrangement, derived from debromoaplysiatoxin. Nat. Prod. Res. 2019, DOI: 10.1080/14786419.2019.1577840.
Tang Y-H, Wu J, Fan T-T, Zhang H-H, Gong X-X, Cao Z-Y, Zhang J, Lin H-W, Han B-N*. Chemical and biological study of aplysiatoxin derivatives showing inhibition of potassium channel Kv1.5. RSC Advances. 2019, 9, 7594 - 7600.
Kai‐Xiong Ye,Ting‐Ting Fan,Lawrence Jordan Keen,Bing‐Nan Han. A Review of Pigments Derived from Marine Natural Products[J]. Israel Journal of Chemistry,2019,59(5).
Han B-N*, Liang T-T, Keen L J, Fan T-T, Zhang X-D, Xu L, Zhao Q, Wang S-P, Lin H-W. Two Marine Cyanobacterial Aplysiatoxin Polyketides, Neo-debromoaplysiatoxin A and B, with K+ Channel Inhibition Activity. Org. Lett. 2018, 20: 578-581.
Liang T T, Zhao Q, He S, et al. Modeling Analysis of Potential Target of Dolastatin 16 by Computational Virtual Screening.[J]. Chemical & Pharmaceutical Bulletin, 2018, 66(6):602-607.
Wang Y, Yan J, Zhang X, et al. Tolerance properties and growth performance assessment of Yarrowia lipolytic lipase in broilers[J]. Journal of Applied Animal Research, 2017:1-6.
Jinyong Yan *, Bingnan Han（共同第一）, Li Xu, Yunjun Yan, Genhan Zha, Dujie Pan, Liangcheng Jiao, Yaofeng Wang, Catherine Madzak. . Engineering Yarrowia lipolytica to Simultaneously Produce Lipase and Single Cell Protein from Agro-industrial Wastes for Feed.. Scientific Reports， 2018，8:758
Li Liu,Wei Wu,Jing Li,Wei-Hua Jiao,Li-Yun Liu,Jie Tang,Lei Liu,Fan Sun,Bing-Nan Han,Hou-Wen Lin. Two sesquiterpene aminoquinones protect against oxidative injury in HaCaT keratinocytes via activation of AMPKα/ERK-Nrf2/ARE/HO-1 signaling[J]. Biomedicine & Pharmacotherapy,2018,100.
Dezhi Li, Bingnan Han, Rui Wei,el. N-terminal α-amino group modification of antibodies using a site-selective click chemistry method[J]. Mabs, 2018:00-00.
Meilin Zhu, Zhen Yang, Huimin Feng, Qi Gan, Qian Che, Tianjiao Zhu, Qianqun Gu, Bingnan Han * and Dehai Li *. Trichodermamides D–F, heterocyclic dipeptides with a highly functionalized 1,2-oxazadecaline core isolated from the endophytic fungus Penicillium janthinellum HDN13-309. RSC Advances. 2017, 7, 48019–48024.
Zhen Yang, Mei-lin Zhu, De-hai Li*, Rong Zeng *, Bing-nan Han *. N-Me-trichodermamide B isolated from Penicillium janthinellum, with antioxidant properties through Nrf2-mediated signaling pathway. Bioorg. Medi. Chem. 31 Oct 2017, 25(24):6614-6622
Qiu-Ye Chai, Zhen Yang, Hou-Wen Lin,* and Bing-Nan Han*. Alkynyl-Containing Peptides of Marine Origin: A Review Mar. Drugs 2016, 14, 216; doi:10.3390
Jian-Hong Gan, Wen-Zhen Hu, Hao-Bing Yu, Fan-Yang, Meng-Xue Cao, Hua-Jin Shi, Yong-Feng Kang* and Bing-Nan Han*. Three New Aaptamine Derivatives from the South China Sea Sponge Aaptos aaptos. J. Asian Natural Products Research; 2015 17(12), 1231-1238
Kai-Xuan Zhan, Wei-Hua Jiao, Fan Yang, Jing Li, Shu-Ping Wang, Yu-Shan Li,Bing-Nan Han,*（共同通讯） and Hou-Wen Lin *. Reniochalistatins A–E, Cyclic Peptides from the Marine Sponge Reniochalina stalagmitis. J. Nat. Prod. ;2014, 77 (12), pp 2678–2684
Shu-Juan Piao, Wei-Hua Jiao, Fan Yang, Yang-Hua Yi, Ying-Tong Di, Bing-Nan Han,*（共同通讯） and Hou-Wen Lin *. New Hippolide Derivatives, withProtein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity from the Marine Sponge Hippospongia lachne. Mar. Drugs; 2014, 12(7), 4096-4109
Shu-Juan Piao,Yun-Long Song,Wei-Hua Jiao,Fan Yang,§ Xiang-Fang Liu, Wan-Sheng Chen, Bing-Nan Han*（共同通讯）, and Hou-Wen Lin*. Hippolachnin A, a New Antifungal Polyketide from the South China Sea Sponge Hippospongia lachne.Org. Lett.；15 (14), 3526–3529，2013
Bingnan Han*, Rachel Wright, Yi Fang, Aaron Kirchoff, Vincent jo Davisson, Julia Chester and Eric Barker . Quantitative LC–MS/MS analysis of arachidonoyl amino acids in mouse brain with treatment of FAAH inhibitor. Analytical Biochemistry; 432(2),74-81，2013
Bingnan Han, Mike Hare and Claudia S. Maier. A differential “Bottom Up” proteomic strategy for the site-specific identification and quantitation of endogenous oxylipid protein modifications. Journal of proteomics ；75(18)，5724-5733, 2012
Bingnan Han, Luke H. Stockwin, Chad Hancock, Sherry X. Yu, Melinda G. Hollingshead, and Dianne L. Newton. Proteomic Analysis of Nuclei isolated from cancer cell lines treated with Indenoisoquinoline NSC724998, a novel Top1 inhibitor.Journal of Proteome Research; 9(8), 4016-4027, 2010