个人简历

1. 1994.09-1999.07 延安大学医学院，临床医学系，医学学士
2. 1999.07-2002.08 陕西省汉中市中心医院，病理科，住院医师
3. 2002.09-2005.06 西安交通大学医学院，病理学，医学硕士
4. 2005.07-2013.07 浙江理工大学，生命科学学院，讲师
5. 2013.07-2016.09 荷兰鹿特丹伊拉兹马斯大学，医学中心，肝肠胃病，医学博士
6. 2016-09-今 浙江理工大学，生命科学学院，讲师

研究领域

1.肝癌靶向治疗
2.肿瘤免疫研究

近期论文

1. K Chen, B Ma, MP Peppelenbosch, Q Pan*. Cytoplasmic rods and rings in mycophenolic acid treatment. Liver Int. Letter, 2017 Jul 26. doi: 10.1111/liv.13530. (IF=4.12)
2. K Chen, K Sideras, B Ma, W Cao, L J van de Laan, D Sprengers, R Smits, H J Metselaar, J Kwekkeboom, M P Peppelenbosch, Q Pan*. Nuclear localization of IMPDH2, the primary target of mycophenolic acid, constrains hepatocellular carcinoma. J Hepatology, supplement, 2016, 64(20); S567.(IF=10.59）
3. K Chen, W Cao, J Li, D Sprengers, P Y. Hernanda, X Kong, Luc J. W. van der Laan, K Man, J Kwekkeboom, H J. Metselaar, M P. Peppelenbosch, Q Pan*. Differential Sensitivities of Fast- and Slow-cycling Cancer Cells to Inosine Monophosphate Dehydrogenase 2 Inhibition by Mycophenolic Acid. Mol Med. 2015, Oct 13; 21; 792-802. (IF=3.53）
4. P Y Hernanda, K Chen (co-first author), A M Das, K Sideras, W Wang, J Li, W Cao, S J A Bots, L L Kodach, R A de Man, J N M Ijzermans, H L A Janssen, A P Stubbs, D Sprengers, M J Bruno, H J Metselaar, T L M ten Hagen, J Kwekkeboom, M P Peppelenbosch, Q Pan*. SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma. Oncogene, 2015, Sep 24; 34(39):5055-68. (IF=7.93）
5. K Chen, K Man, H J. Metselaar, H L. A. Janssen, M P. Peppelenbosch, Q Pan*. Rationale of personalized immunosuppressive medication for hepatocellular carcinoma patients after liver transplantation. Liver Transpl. 2014, 20 (3); 261-9. (IF=4.24)
6. K Chen, Q Pan, Y Gao, X Yang, S Wang, M P. Pepplenbosch, X Kong*. DMS triggers apoptosis associated with inhibition of SPHK1/NF-κB activation and increase of intracellular Ca2+ concentration in human cancer cells. Int J Mol Med. 2014, Jan 33(1); 17-24. (IF=2.348)
7. K Chen, K Man, H J Metselaar, H L A Janssen, J Kwekkeboom, D Sprengers, M J Bruno, M P Peppelenbosch, Q Pan*. IMPDH2-targeted constrain of cell growth in hepatocellular carcinoma by mycophenolic acid. J Hepatology, supplement, 2014, 60(1); S88. (IF=10.59)
8. K Chen, X Yang, L Wu, M Yu, X Li, N Li, S Wang, G Li*. Pinellia pedatisecta Agglutinin Targets Drug Resistant K562/ADR Leukemia Cells through Binding with Sarcolemmal Membrane Associated Protein and Enhancing Macrophage Phagocytosis. PLoS ONE. 2013, 8(9); e74363. (IF=3.057)
9. W Cao, K Chen, M Bolkestein, Y Yin, MMA Verstegen, MJC Bijvelds, W Wang, N Tuysuz, B D Ten, D Sprengers, HJ Metselaar, LJW van der Laan, J Kwekkeboom, R Smits, MP Peppelenbosch, Q Pan*. Dynamics of Proliferative and Quiescent Stem Cells in Liver Homeostasis and Injury. Gastroenterology. 2017 Jul 14. pii: S0016-5085(17)35907-3. (IF=18.187）
10. G Ying, G Fei, C Kan, T Mei-li, Z Dong-li*. Sphingosine kinase 1 as an anticancer therapeutic target. DRUG DES DEV and THER, 2015, Jun 23; (9);3239-45. (IF=2.88）
11. Y Wang, X Zhou, Y Debing, K Chen, L JW. Vander Lanna, J Neyts, H L.A. Janssen, He J. Metselaar, M P Peppelenbosch, Q Pan*. Calcineurin inhibitors stimulate and mycophenolic acid inhibits replication of hepatitis E virus. Gastroenterology, 2014, 146(7);1775-83. (IF=18.187）
12. Y Gao*, K Chen, J Ma, F Gao. Cerium oxide nanoparticles in cancer. Onco Targets Ther, 2014, 7:835-40. （IF=2.272）