个人简历

2018年1月-至今，浙江大学化工学院，副教授、博士生导师\r
2015年3月-2017年12月，浙江大学化工学院，讲师\r
2015年3月回国加入申有青课题组\r
2011-2015年，美国凯斯西储大学生物医学工程系，博士后，Zheng-Rong Lu\r
2006-2011年，美国怀俄明大学化工系，博士，Youqing Shen\r
2003-2006年，浙江大学高分子系，硕士，孙维林\r
1999-2003年，浙江大学高分子系，学士\r

研究领域

"""""高分子纳米载体材料用于造影剂、药物分子与活性大分子的高效靶向递送\r
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1.高分子纳米载体的精准合成与修饰\r
构建结构精准可控、可重复性高、药物释放可调的树状大分子和高分子自组装纳米药物输送系统。\r
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2.高分子纳米载体用于早期肿瘤精准定位与定性诊断\r
构建靶向于肿瘤微环境的造影剂输送系统（核磁共振造影剂、荧光探针等），实现对微小肿瘤的早期检测以及恶性程度判断。\r
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3. 高分子纳米载体用于肿瘤的高效治疗\r
构建靶向于肿瘤的高效纳米药物输送系统，针对肿瘤的特异性，研制自适应性纳米药物提高输送各步的效率：延长血液循环时间、提高肿瘤积蓄、提高肿瘤内渗透性、增加细胞内吞速率和实现高效药物定点释放。"

近期论文

Kexin Liu, Jiajia Xiang, Guowei Wang, Hongxia Xu, Ying Piao, Xiangrui Liu, Jianbin Tang, Youqing Shen, Zhuxian Zhou*, Linear-Dendritic Polymer-Platinum Complexes Forming Well-Defined Nanocapsules for Acid-Responsive Drug Delivery. ACS Applied Materials & Interfaces 2021, 13, 37, 44028–44040.\r
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Xinhao Fang, Kai Gao, Jianxiang Huang, Kexin Liu, Linying Chen, Ying Piao, Xiangrui Liu, Jianbin Tang, Youqing Shen, Zhuxian Zhou*, Molecular level precision and high molecular weight peptide dendrimers for drug-specific delivery. Journal of Materials Chemistry B 2021, DOI: 10.1039/D1TB01157J.\r
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Bo Zhang, Hongwen Chen, Qiuhui Hu, Liming Jiang, Youqing Shen, Dan Zhao, Zhuxian Zhou*, CelluMOFs: Green, Facile, and Flexible Metal-Organic Frameworks for Versatile Applications Advanced Functional Materials 2021, 31:2105395.\r
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Guowei Wang, Chao Zhang, Yifan Jiang, Yue Song, Jifan Chen, Yu Sun, Qunying Li, Zhuxian Zhou*, Youqing Shen*, Pintong Huang*, Ultrasonic Cavitation-Assisted and Acid-Activated Transcytosis of Liposomes for Universal Active Tumor Penetration. Advanced Functional Materials 2021, 31:2102786.\r
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Hongwen Chen, Huaqiang Chen, Bo Zhang, Liming Jiang, Youqing Shen, Engang Fu, Dan Zhao, Zhuxian Zhou*, Tuning the release rate of volatile molecules by pore surface engineering in metal-organic frameworks. Chinese Chemical Letters 2021, 32:1988-1992.\r
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Zhen Zhang, Nasha Qiu, Shuling Wu, Xin Liu, Zhuxian Zhou, Jianbin Tang, Yanpeng Liu, Ruhong Zhou, Youqing Shen*, Dose-Independent Transfection of Hydrophobized Polyplexes. Advanced Materials 2021, 33:2102219.\r
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Shiqi Hu#, Haiping Jiang#, Jianqiang Zhu, Jinqiang Wang, Shunhao Wang, Jianbin Tang, Zhuxian Zhou*, Sijin Liu*, Youqing Shen*, Tumor-Specific Fluorescence Activation of Rhodamine Isothiocyanate Derivatives. Journal of Controlled release 2021, 330:842-850.\r
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Doudou Hu, Wei Zhang, Jianbin Tang, Zhuxian Zhou, Xiangrui Liu, Youqing Shen. Improving safety of cancer immunotherapy via delivery technology. Biomaterials 2021, 265:120407.\r
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Dongdong Li, Doudou Hu, Hongxia Xu, Hirak K Patra, Xiangrui Liu, Zhuxian Zhou, Jianbin Tang, Nigel Slater, Youqing Shen. Progress and perspective of microneedle system for anti-cancer drug delivery. Biomaterials 2021, 264:120410.\r
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Guowei Wang, Bihan Wu, Qunying Li, Siqin Chen, Xiaoqin Jin, Yajing Liu, Zhuxian Zhou,*Youqing Shen,* Pintong Huang*. Active Transportation of Liposome Enhances Tumor Accumulation, Penetration, and Therapeutic Efficacy. Small 2020; 16:2004172. (2020 IF:11.459)\r
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Shiqi Hu#, Chengyuan Dong#, Jinqiang Wang, Kexin Liu, Quan Zhou, Jiajia Xiang, Zhuxian Zhou*, Fusheng Liu*, Youqing Shen*. Assemblies of Indocyanine Green and Chemotherapeutic Drug to Cure Established Tumors by Synergistic Chemo-Photo Therapy. Journal of Controlled Release 2020;324:250-259. (2019 IF: 7.901)\r
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Hailin Cong#, Kaiqi Wang#, Zhuha Zhou, Jiajia Yang, Ying Piao, Bing Yu, Youqing Shen, Zhuxian Zhou*. Tuning the Brightness and Photostability of Organic Dots for Multivalent Targeted Cancer Imaging and Surgery. ACS Nano 2020;14:5887-5900.[link] (2019 IF: 13.903)\r
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Guowei Wang, Zhuxian Zhou*, Zhihao Zhao, Qunying Li, Yulian Wu, Sheng Yan, Youqing Shen*, Pintong Huang*. Enzyme-Triggered Transcytosis of Dendrimer-Drug Conjugate for Deep Penetration into Pancreatic Tumors. ACS Nano 2020;14:4890-4904.[link] (2019 IF: 13.903)\r
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Guowei Wang#, Dingcheng Zhu#, Zhuxian Zhou*, Ying Piao, Jianbin Tang, Youqing Shen*. A Glutathione-Specific and Intracellularly Labile Polymeric Nanocarrier for Efficient and Safe Cancer Gene Delivery. ACS Applied Materials & Interfaces 2020;12:14825-14838.[link] (2019 IF: 8.456)\r
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Chengyuan Dong#, Quan Zhou#, Jiajia Xiang*, Fusheng Liu*, Zhuxian Zhou*, Youqing Shen. Self-assembly of Oxidation-Responsive Polyethylene Glycol-Paclitaxel Prodrug for Cancer Chemotherapy. Journal of Controlled Release 2020;321:529-539.[link] (2019 IF: 7.901)\r
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Jiafeng Wang, Xuefei Zhou, Huifang Wang, Qian Xiao, Kefeng Ding, Xue Dong, Shufeng Xu, Bo Shen, Jihong Sun, Zhuxian Zhou, Jianbin Tang, Xiangrui Liu*, Youqing Shen Autophagy-inhibiting polymer as an effective nonviral cancer gene therapy vector with inherent apoptosis-sensitizing ability. Biomaterials 2020, 255:120156.\r
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Kaojin Wang, Kamran Amin, Zesheng An, Zhengxu Cai, Hong Chen, Hongzheng Chen, Yuping Dong, Xiao Feng, Weiqiang Fu, Jiabao Gu, Yanchun Han, Doudou Hu, Rongrong Hu, Die Huang, Fei Huang, Feihe Huang, Yuzhang Huang, Jian Jin, Xin Jin, Qianqian Li, Tengfei Li, Zhen Li, Zhibo Li, Jiangang Liu, Jing Liu, Shiyong Liu, Huisheng Peng, Anjun Qin, Xin Qing, Youqing Shen, Jianbing Shi, Xuemei Sun, Bin Tong, Bo Wang, Hu Wang, Lixiang Wang, Shu Wang, Zhixiang Wei, Tao Xie, Chunye Xu, Huaping Xu, Zhi-Kang Xu, Bai Yang, Yanlei Yu, Xuan Zeng, Xiaowei Zhan, Guangzhao Zhang, Jie Zhang, Ming Qiu Zhang, Xian-Zheng Zhang, Xiao Zhang, Yi Zhang, Yuanyuan Zhang, Changsheng Zhao, Weifeng Zhao, Yongfeng Zhou, Zhuxian Zhou, Jintao Zhu, Xinyuan Zhu, Ben Zhong Tang*. Advanced functional polymer materials. Materials Chemistry Frontiers 2020, 4:1803-1915.\r
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Dan Tian#, Hongxia Xu#, Bing Xiao, Xiaoxuan Zhou, Xiangrui Liu, Zhuxian Zhou, Hirak Kumar Patra*, Nigel KH Slater, Jianbin Tang*, Youqing Shen. Single-Step Formulation of Levodopa-Based Nanotheranostics–Strategy for Ultra-Sensitive High Longitudinal Relaxivity MRI Guided Switchable Therapeutics. Biomaterials Science 2020;8:1615-1621.[link] (2019 IF: 5.251)\r
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Bing Xiao#, Xiaoxuan Zhou#, Hongxia Xu, Wei Zhang, Xiaodan Xu, Fengjuan Tian, Yue Qian, Feidan Yu, Cailing Pu, Hongjie Hu, Zhuxian Zhou, Xiangrui Liu, Hirak K Patra, Nigel Slater, Jianbin Tang*, Jianqing Gao, Youqing Shen. On/off switchable epicatechin-based ultra-sensitive MRI-visible nanotheranostics – see it and treat it. Biomaterials Science 2020, 8: 5210-5218.\r
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Zixie Li, Jianxiang Huang, Long Ye, Yichao Lv, Zhuxian Zhou, Youqing Shen, Yi He, Liming Jiang*. Encapsulation of Highly Volatile Fragrances in Y Zeolites for Sustained Release: Experimental and Theoretical Studies. ACS Omega 2020, 5:31925-31935.