个人简历

1994-1997 哥伦比亚大学 生物物理化学 博士 PhD\r
1988-1990 浙江大学 凝聚态物理 硕士 MS\r
1986-1988 浙江大学 物理 学士 BS\r
1984-1986 浙江大学 首届混合班 荣誉学位\r
\r
周如鸿，AAAS Fellow, APS Fellow, 浙江大学求是讲席教授，生命科学院院长，上海高等研究院院长，科技部十四五“生物大分子与微生物”专家组成员，哥伦比亚大学化学系兼职教授。2000-2020年期间在 IBM Watson 研究院工作，历任研究员，杰出研究员，蛋白质科学实验室主任，软物质科学系系主任，IBM蓝色基因计划生命科学首席科学家等；同时，2002年起在哥伦比亚大学化学系担任兼职助理教授，兼职教授，开设《生物物理化学》，《高等统计力学》等课程; 2020年全职回到母校工作，并参与筹建浙江大学定量生物中心与浙江大学上海高等研究院。长期从事计算生物学、生物物理、生物化学与人工智能+等交叉学科的研究，在蛋白质设计、纳米药物设计、肿瘤免疫机制等领域取得了一系列国际领先的原创性成果。授权30余项国际专利，在国际权威学术刊物发表论文300余篇 (其中 2篇 Nature，2篇 Science，1篇 Cell，19篇 Nature子刊，16篇 PNAS， 14篇 JACS)，文章总引用超过25000余次，H因子81 （Google Scholar）。曾获全美化学学会计算化学奖 (DEC Award)，IBM杰出科技贡献奖 (IBM技术类最高奖)，IBM杰出创新奖, 并于2009年以IBM蓝色基因计划主要成员之一荣获奥巴马总统颁发的美国国家技术奖章 (总统奖)。周如鸿教授于2011年当选美国科学促进会会士 (AAAS Fellow)，美国物理学会会士(APS Fellow)，并于2012年入选IBM全球八大研究院“将对IBM，对世界，可能产生最重大影响的五名科学家之一”。周如鸿教授同时担任美国分子科学领域顶尖的Telluride科学研究中心董事会的董事（Board of Directors），和美国芝加哥大学多尺度科学中心的科学顾问（Scientific Advisory Board）。

研究领域

"""""I. 免疫分子机制\r
A. 肿瘤免疫\r
B.传染病\r
C. 自免疫疾病 I-型糖尿病 （T1D）\r
\r
II. 生物分子相互作用\r
A. 蛋白质折叠、误折叠与集聚\r
B. 生物系统纳米尺度的去湿润相变\r
C. 亨廷顿病分子机制\r
\r
III. 纳米药物\r
A. 石墨烯抗菌机制\r
B. 内嵌金属富勒醇抗肿瘤 \r
C. 功能石墨烯抗阿尔兹海默症"

近期论文

Qiang Zhu#, Hong Zhou#, Liming Wu, Jie Zhang, Yong Wang, Didi Geng, Zhiya Fan, Weijie Qin, Ruhong Zhou*, and Wen Yi*, O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1, Nature Chem. Biol., 18, 1087-1095, 2022, DOI:10.1038/s41589-022-01085-5\r
\r
Chengyu Shi#, Ying Wang#, Minjie Wu#, Yu Chen, Fangzhou Liu, Zheyuan Shen, Yiran Wang, Shaofang Xie, Yingying Shen, Lingjie Sang, Zhen Zhang, Zerui Gao, Luojia Yang, Lei Qu, Zuozhen Yang, Xinyu He, Yu Guo, Chenghao Pan, Jinxin Che, Huaiqiang Ju, Jian Liu, Zhijian Cai, Qingfeng Yan, Luyang Yu, Liangjing Wang, Xiaowu Dong, Pinglong Xu, Jianzhong Shao, Yang Liu, Xu Li*, Wenqi Wang*, Ruhong Zhou*, Tianhua Zhou* and Aifu Lin*, Promoting anti-tumor immunity by targeting TMUB1, a modulator 2 of PD-L1 polyubiquitination and glycosylation, Nature Commun. 13, 6951, 2022\r
\r
Xiaolong Li*, Nishant Kumar Singh, Robert Ng, David R. Collins, Angela Zhang, Pedro A. Lamothe-Molina, Peter Shahinian, Shutong Xu, Kemin Tan, Alicja Piechocka-Trocha, Jonathan M. Urbach, Jeffrey K. Weber, Gaurav Gaiha, Overbeck Christian Takou Mbah, Tien Huynh, Sophia Cheever, James Chen, Michael Birnbaum, Ruhong Zhou, Bruce D. Walker*, and Jia-huai Wang*, Molecular basis of differential HLA class I-restricted T cell 2 recognition of a highly networked viral peptide, Nature Commun. 13, 3rd revision, 2022\r
\r
Meng Jiang#, Binqiang Wang#, Rui Ye#, Ning Yu, Zhenming Xie, Yuejin Hua, Ruhong Zhou*, Bing Tian,*, Shang Dai,* Evidence and impacts of nanoplastic accumulation in crop grains, Advanced Science, 9, 2202336, 2022\r
\r
Shang Dai#, Rui Ye#, Jianxiang Huang, Binqiang Wang, Zhenming Xie, Xinwen Ou, Ning Yu, Cheng Huang, Yuejin Hua*, Ruhong Zhou*, Bing Tian*, Distinct lipid membrane interaction and uptake of differentially charged nanoplastics in bacteria, J. Nanobio. 20, 1-15, 2022\r
\r
Zonglin Gu#, Zhi He#, Fanfan Chen#, Lijun Meng, Jiandong Feng, Ruhong Zhou*, Ionic Liquid Decelerates Single-Stranded DNA Transport through Molybdenum Disulfide Nanopores, ACS Appl. Mater. Interf. 14, 32618-32624, 2022\r
\r
Meiyun Xu#, Shitong Zhang#, Tao Wang, Bin Yu, Zaixing Yang, Xiaolin Wang*, Ruhong Zhou*, Daoben Hua*, De Novo Design of a Pt Nanocatalyst on a Conjugated Microporous Polymer-Coated Honeycomb Carrier for Oxidation of Hydrogen Isotopes, ACS Appl. Mater. Interf. 14, 7826-7835, 2022\r
\r
Meiyun Xu, Lei Zhou, Linjuan Zhang, Shitong Zhang, Fulong Chen, Ruhong Zhou, Daoben Hua*, Two-Dimensional Imprinting Strategy to Create Specific Nanotrap for Selective Uranium Adsorption with Ultrahigh Capacity, ACS Appl. Mater. Interf. 14, 9408-9417, 2022\r
\r
Leili Zhang, Hongsuk Kang, Jose M. Perez-Aguilar, Ruhong Zhou*, Possible Co-Evolution of Polyglutamine and Polyproline in Huntingtin Protein: Proline-Rich Domain as Transient Folding Chaperone, J. Phys. Chem. Lett, 13, 6331-6341, 2022, DOI: 10.1021/acs.jpclett.2c01184\r
\r
Jianxiang Huang#, Wei Song#, Lijun Meng#, Youqing Shen, Ruhong Zhou*, Role of polyplex charge density in lipopolyplex, Nanoscale, 14, 7174-7180, 2022\r
\r
Lijun Meng#, Jianxiang Huang#, Zhi He, Ruhong Zhou*, Single nucleobase identification for transversally-confined ssDNA using longitudinal ionic currents, Nanoscale, 14, 6922-6929, 2022\r
\r
Panli Han, Lianxue Zhang*, Yaqi Fu, Youyu Fu, Jianxiang Huang, Jinlin He, Peihong Ni, Taimoor Khan, Yang Jiao, Zaixing Yang and Ruhong Zhou*, A Dual-response Drug Delivery System with X-ray and ROS to Boost the Anti-Tumor Efficiency of TPZ via Enhancement of Tumor Hypoxia Level, Nanoscale, 14, in press, 2022\r
\r
Quan Zhou#, Jianxiang Huang#, Lingqiao Hao, Yu Geng, Changhuo Xu, Zhuxian Zhou, Jianbin Tang, Ruhong Zhou*, Youqing Shen*, Hydrophobicity Effects of γ-Glutamyl Transpeptidase-Responsive Polymers on the Catalytic Activity and Transcytosis Efficacy, Bioconjugate Chem., 33, 2132-2142, 2022, DOI: 10.1021/acs.bioconjchem.2c00391\r
\r
Guotao Yuan#, Shitong Zhang#, Zaixing Yang, Shunjie Wu, Huanjun Chen, Xin Tian, Si Cheng, Yue Pan*, Ruhong Zhou*, Precisely modulated 2D PdCu alloy nanodendrites as highly active peroxidase mimics for the elimination of biofilms, Biomater. Sci., in press, 2022\r
\r
Danni Li#, Jianxiang Huang#, Yichong Lao, Yiling Zhang, Wei Song, Jie Song, Cong Liu, Bin Dai*, Ruhong Zhou*, Potassium Ion Mediated Double-Layered Upright Assembly of Negatively Charged Amyloid-like Peptides at Mica/Water Interface, Adv. Mater. Interf., 9, 2200402, 2022, DOI: 10.1002/admi.202200402\r
\r
Dan Qiao, Yuang Chen, Haojing Tan, Ruhong Zhou & Jiandong Feng*, De novo design of transmembrane nanopores, Sci. China Chem. 65, in press, 2022, DOI: 10.1007/s11426-022-1354-5\r
\r
Kevin C Chan, Yi Song, Zheng Xu, Chun Shang, Ruhong Zhou*, SARS-CoV-2 Delta Variant: Interplay between Individual Mutations and Their Allosteric Synergy, Biomolecules, 12, 1742, 2022\r
\r
Yi Song, Sangyun Lee, David Bell, Benjamin Goudey, Ruhong Zhou*, Binding Affinity Calculations of Gluten Peptides to HLA Risk Modifiers: DQ2. 5 versus DQ7. 5, J. Phys. Chem. B, 126, 5151-5160, 2022\r
\r
Qing Guo#, Ying Yang#, Lin Zhao, Jian Chen, Guangxin Duan*, Zaixing Yang*, Ruhong Zhou, Graphene oxide toxicity in W1118 flies, Sci. Tot. Environ. 805, 150302, 2022\r
\r
Guangqiang Yin, Jianxiang Huang, Depeng Liu, Rui Li, Shuxin Wei, Muqing Si, Feng Ni, Yinfei Zheng, Qiu Yang, Ruhong Zhou*, Xiaoxia Le*, Wei Lu, Tao Chen*, Mechanochemical transformation of fluorescent hydrogel based on dynamic lanthanide-terpyridine coordination, Chin. Chem. Lett. DOI:10.1016/j.cclet.2022.03.013, 2022\r
\r
Guotao Yuan#, Shitong Zhang#, Zaixing Yang, Xin Tian, Si Cheng, Yue Pan*, Ruhong Zhou*, 2D PdCu Alloy Nanodendrites Manifest Effective Peroxidase-Like Activity Against Biofilms, Research Square DOI:10.21203/rs.3.rs-1162314/v1, 2022\r
\r
Giacomo Domeniconi, Leili Zhang, Guojing Cong, Chih-Chieh Yang, Ruhong Zhou, Optical Flow Based Forecasting of Binding States in Molecular Dynamic Simulations, US Patent Pub. 17,154,120, July 21, 2022\r
\r
Giacomo Domeniconi, Leili Zhang, Guojing Cong, Chih-Chieh Yang, Ruhong Zhou, Altering protein-ligand structure according to protein-ligand binding affinity, US Patent Pub. 17,065,548, April 14, 2022\r
\r
Zhen Zhang, Nasha Qiu, Shuling Wu, Xin Liu, Zhuxian Zhou, Jianbin Tang, Yanpeng Liu, Ruhong Zhou, Youqing Shen*,Dose-Independent Transfection of Hydrophobized Polyplexes, Adv. Mater. 33, 2102219, 2021 DOI: 10.1002/adma.202102219 \r
\r
Linwei He#, Long Chen#, Xinglong Dong#, Shitong Zhang#, Mingxing Zhang, Xing Dai, Xiajie Liu, Peng Lin, Kunfeng Li, Cailing Chen, Tingting Pan, Fuyin Ma, Junchang Chen, Mengjia Yuan, Yugang Zhang, Lei Chen, Ruhong Zhou, Yu Han*, Zhifang Chai, Shuao Wang*,A nitrogen-rich covalent organic framework for simultaneous dynamic capture of iodine and methyl iodide, Chem, 7, 699-714, 2021\r
\r
Fanfan Chen#; Zonglin Gu#; Chunxiao Zhao; Yuang Chen; Xiaowei Jiang; Zhi He; Yuxian Lu; Ruhong Zhou; Jiandong Feng*, Ionic conductance oscillations in sub-nanometer pores probed by optoelectronic control, Matter, 4,2378-2391, 2021\r
\r
Zhi He, Ruhong Zhou*, Exploring an In-Plane Graphene and Hexagonal Boron Nitride Array for Separation of Single Nucleotides, ACS Nano, 15, 11704 - 11710, 2021 DOI: 10.1021/acsnano.1c02450\r
\r
Guang-Qiang Yin, Sneha Kandapal, Chung-Hao Liu, Heng Wang, Jianxiang Huang, Shu-Ting Jiang, Tan Ji, Yu Yan, Sandra Khalife, Ruhong Zhou, Libin Ye, Bingqian Xu, Hai-Bo Yang, Mu-Ping Nieh, Xiaopeng Li*, Metallo-Helicoid with Double Rims: Polymerization Followed by Folding by Intramolecular Coordination, Angew. Chem. 60, 1281-1289, 2021 DOI: 10.1002/anie.202010696\r
\r
Mei Feng#, Yi Song#, Serena H Chen, Yuanzhao Zhang, Ruhong Zhou*, Molecular Mechanism of Secreted Amyloid-β Precursor Protein in Binding and Modulating GABABR1a, Chem. Sci., 12,6107-6116, 2021,DOI: 10.1039/D0SC06946A\r
\r
Zonglin Gu#, Austin M. Baggetta#, Yu Chong, Leigh D. Plant*, Xuan-Yu Meng*, Ruhong Zhou*,Multifaceted Regulation of Potassium Ion Channels by Graphene Quantum Dots, ACS Appl. Mater. Interf. 13, 27784-27795, 2021\r
\r
Rui Ye, Wei Song, Mei Feng, Ruhong Zhou*, Potential interference of graphene nanosheet to immune response via disrupting the recognition of TCR to HLA-presented KK10: A molecular dynamics simulation study, Nanoscale, 13, 19255-19263, 2021\r
\r
Xinyu Zhang#, Shitong Zhang#, Zaixing Yang, Zhuanhua Wang*, Xin Tian*, Ruhong Zhou*, Self-cascade MoS 2 nanozymes for efficient intracellular antioxidation and hepatic fibrosis therapy, Nanoscale, 13, 12613-12622, 2021\r
\r
Dan Zhu, Jiang Li, Lian-Hui Wang, Qian Li, Lihua Wang, Bo Song, Ruhong Zhou*, Chunhai Fan*, Hydrophobic Collapse-Driven Nanoparticle Coating with Poly-Adenine Adhesives, Chem. Commun., 57, 3801-3804, 2021, DOI: 10.1039/D1CC00628B \r
\r
Xuchang Su, Zhi He, Lijun Meng, Hong Liang, Ruhong Zhou*, Planar Boronic Graphene and Nitrogenized Graphene Heterostructure for Protein Stretch and Confinement, Biomolecules, 11, 1756, 2021\r
\r
Mei Feng, Sangyun Lee, Chun Chan, Ruhong Zhou*, Molecular Insight into AC Electric Field Enhanced Removal of Protein Aggregates from a Material Surface, J. Phys. Chem. B, 125, 12147-12153, 2021\r
\r
Dong Zhang, Shi-Jie Chen*, Ruhong Zhou*, Modeling Noncanonical RNA Base Pairs by a Coarse-Grained IsRNA2 Model, J. Phys. Chem. B, 125, 11907-11915, 2021\r
\r
Xiaotong Lei, Shengtang Liu, Ruhong Zhou, Xuan-Yu Meng*, Molecular Dynamics Simulation Study on Interactions of Cycloviolacin with Different Phospholipids, J. Phys. Chem. B, 125, 3476-3485,2021\r
\r
Xuejie Xie#, Zhenyu Hou#, Guangxin Duan#, Shitong Zhang, Hong Zhou, Zaixing Yang*, Ruhong Zhou*, Boron nitride nanosheets elicit significant hemolytic activity via destruction of red blood cell membranes,Colloids and Surfaces B: Biointerfaces, 203, 111765, 2021\r
\r
Huizhen Zheng, Zonglin Gu, Yanxia Pan, Jie Chen, Qianqian Xie, Shujuan Xu, Meng Gao, Xiaoming Cai, Shengtang Liu, Weili Wang, Wei Li, Xi Liu, Zaixing Yang*, Ruhong Zhou, Ruibin Li*, Biotransformation of rare earth oxide nanoparticles eliciting microbiota imbalance,Particle and fibre toxicology, 18, 1-14, 2021\r
\r
Tingjie Zhan, Leili Zhang, Shixuan Cui, Weiping Liu, Ruhong Zhou, Shulin Zhuang*, Dioxybenzone triggers enhanced estrogenic effect via metabolic activation: in silico, in vitro and in vivo investigation,Environmental Pollution, 268, 115766, 2021 \r
\r
Leili Zhang#,*, Giacomo Domeniconi#,*, Chih-Chieh Yang, Seung-gu Kang, Ruhong Zhou, Guojing Cong, CASTELO: Clustered Atom Subtypes aidEd Lead Optimization--a combined machine learning and molecular modeling method,BMC Bioinformatics, 22, 338, 2021 \r
\r
Pu Chun Ke, Ruhong Zhou, Louise C Serpell, Roland Riek, Tuomas PJ Knowles, Hilal A Lashuel, Ehud Gazit, Ian W Hamley, Thomas P Davis, Marcus Fändrich, Daniel Erik Otzen, Matthew R Chapman, Christopher M Dobson, David S Eisenberg, Raffaele Mezzenga*, Half a century of amyloids: past, present and future, Chem. Soc. Rev. 49, 5473-5509, 2020, DOI: 10.1039/C9CS00199A\r
\r
Xiaochuan Ma#, Sangyun Lee#, Xingshu Fei, Ge Fang, Tien Huynh, Chunying Chen, Zhifang Chai, Cuicui Ge*, Ruhong Zhou*,Proteasome activity regulated by charged gold nanoclusters: Implications for neurodegenerative diseases, Nano Today, 35, 100933, 2020\r
\r
Nannan Shen#, Zaixing Yang#, Shengtang Liu#, Xing Dai, Chengliang Xiao, Kathryn Taylor-Pashow, Dien Li, Chuang Yang, Jie Li, Yugang Zhang, Mingxing Zhang, Ruhong Zhou*, Zhifang Chai, Shuao Wang*,99TcO4−removal from legacy defense nuclear waste by an alkaline-stable 2D cationic metal organic framework, Nature Communications, 11, 5571, 2020\r
\r
David R Bell, Jeffrey K Weber, Wang Yin, Tien Huynh, Wei Duan*, Ruhong Zhou*, In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers, Proc. Natl. Acad. Sci., 117, 8486–8493, 2020\r
\r
Mingxing Zhang#, Junchang Chen#, Shitong Zhang#, Xiaoqi Zhou, Linwei He, Matthew V Sheridan, Mengjia Yuan, Maojiang Zhang, Long Chen, Xing Dai, Fuyin Ma, Jingdong Wang, Jiangtao Hu, Guozhong Wu, Xueqian Kong, Ruhong Zhou, Thomas E Albrecht-Schmitt, Zhifang Chai, Shuao Wang*, Electron Beam Irradiation as a General Approach for the Rapid Synthesis of Covalent Organic Frameworks under Ambient Conditions, J. Am. Chem. Soc., 142, 9169-9174,2020, DOI:10.1021/jacs.0c03941\r
\r
Hanzhou Liu#, Haoming Qin#, Nannan Shen, Siqi Yan, Yaxing Wang, Xuemiao Yin, Xinjian Chen, Chao Zhang, Xing Dai*, Ruhong Zhou, Xiaoping Ouyang, Zhifang Chai, Shuao Wang*, Emergence of Radical Stabilizing Metal‐Organic Framework as a New Type of Radio‐Photoluminescence Dosimeter, Angew. Chem.59, 15209-15214, 2020\r
\r
Dongyang Xu#, Long Chen#, Xing Dai#, Baoyu Li, Yaxing Wang, Wei Liu, Jie Li, Yi Tao, Yanlong Wang, Yong Liu*, Guowen Peng*, Ruhong Zhou, Zhifang Chai, Shuao Wang*,A Porous Aromatic Framework Functionalized with Luminescent Iridium(III) Organometallic Complexes for Turn-On Sensing of 99TcO4–, ACS Appl. Mater. Interf. 12, 15288-15297, 2020\r
\r
Lianxue Zhang#, Shitong Zhang#, Jiaying Xu#, Youyun Li, Jinlin He, Ying Yang, Tien Huynh, Peihong Ni, Guangxin Duan, Zaixing Yang*, Ruhong Zhou*, Low-Dose X-ray-Responsive Diselenide Nanocarriers for Effective Delivery of Anticancer Agents, ACS Appl. Mater. Interf. 12, 43398-43407, 2020\r
\r
Catherine A Bessell#,Ariel Isser#, Jonathan J Havel#, Sangyun Lee, David R Bell, John W Hickey, Worarat Chaisawangwong, Joan Glick Bieler, Raghvendra Srivastava, Fengshen Kuo, Tanaya Purohit, Ruhong Zhou*, Timothy A Chan*, Jonathan P Schneck*, Commensal bacteria stimulate antitumor responses via T cell cross-reactivity, JCI Insight, 5, e135597, 2020\r
\r
Ruhong Zhou*, Thomas Weikl*, Yu-qiang Ma*,Theoretical modeling of interactions at the bio-nano interface, Nanoscale, 12, 10426-10429, 2020\r
\r
Wei Zhang*, Yezhe Chen, Tien Huynh, Yunqiu Yang, Xianqing Yang, Ruhong Zhou*,Directional Extraction and Penetration of Phosphorene Nanosheets to Cell Membranes, Nanoscale, 12, 13822-13828, 2020\r
\r
Zhi He, Ruhong Zhou*,Planar Graphene/h-BN/Graphene Heterostructure for Protein Stretch and Confinement, Nanoscale, 12, 2810-2819, 2020\r
\r
Serena H Chen, Jose Manuel Perez-Aguilar, Ruhong Zhou*,Graphene-extracted membrane lipids facilitate the activation of integrin αvβ8, Nanoscale, 12, 7939-7949, 2020\r
\r
Baoyu Li, Xuejie Xie, Guangxin Duan, Serena H Chen, Xuan-Yu Meng, Ruhong Zhou*,Binding Patterns and Dynamics of Double-stranded DNA on Phosphorene Surface, Nanoscale, 12, 9430-9439, 2020\r
\r
Maja C Ziegler, Annika Nelde, Jeffrey K Weber, Christian M Schreitmüller, Glòria Martrus, Tien Huynh, Madeleine J Bunders, Sebastian Lunemann, Stefan Stevanovic, Ruhong Zhou*, Marcus Altfeld*, HIV-1 induced changes in HLA-C∗03: 04-presented peptide repertoires lead to reduced engagement of inhibitory natural killer cell receptors, AIDS, 34, 1713-1723, 2020\r
\r
Yin Zhong#, Rui Sun#, Yu Geng, Quan Zhou, Ying Piao, Tao Xie, Ruhong Zhou, Youqing Shen*, N-Oxide polymer–cupric ion nanogels potentiate disulfiram for cancer therapy, Biomater. Sci. 8, 1726-1733, 2020\r
\r
Xuanchu Ge, Xing Dai, Hong Zhou, Zaixing Yang, Ruhong Zhou*,Stabilization of Open-Shell Single Bonds within Endohedral Metallofullerene, Inorg. Chem. 59, 3606-3618, 2020\r
\r
Baoyu Li, Yuanzhao Zhang, Xuanyu Meng*, Ruhong Zhou*,Zipper-like Unfolding of dsDNA Caused by Graphene Wrinkles, J. Phys. Chem. C 124, 3332-3340, 2020\r
\r
Leili Zhang, Ruhong Zhou*, Structural basis of potential binding mechanism of remdesivir to SARS-CoV-2 RNA dependent RNA polymerase, J. Phys. Chem. B 124, 6955-6962, 2020\r
\r
Aodong Zou, Peng Xiu, Xinwen Ou, Ruhong Zhou*,Spontaneous Translocation of Single-Stranded DNA in Graphene–MoS2Heterostructure Nanopores: Shape Effect, J. Phys. Chem. B 124, 9490-9496, 2020\r
\r
Zonglin Gu, Jose Manuel Perez-Aguilar, Lijun Meng, Ruhong Zhou*, Partial Denaturation of Villin Headpiece upon Binding to a Carbon Nitride Polyaniline (C3N) Nanosheet, J. Phys. Chem. B 124, 7557-7563, 2020\r
\r
Aodong Zou, Sangyun Lee, Jingyuan Li, Ruhong Zhou*, Retained Stability of the RNA Structure in DNA Packaging Motor with a Single Mg2+Ion Bound at the Double Mg-Clamp Structure, J. Phys. Chem. B 124, 701-707, 2020\r
\r
Wei Song, Zhifeng Jing, Lijun Meng, Ruhong Zhou*, Tungsten Oxide Nanodots Exhibit Mild Interactions with WW and SH3 Modular Protein Domains, ACS Omega, 5, 11005-11012, 2020\r
\r
Rizwan Ahmed, Zahra Omidian, Adebola Giwa, Benjamin Cornwell, Neha Majety, David R. Bell, Sangyun Lee, Hao Zhang, Aaron Michels, Stephen Desiderio, Scheherazade Sadegh-Nasseri, Hamid Rabb, Mario Suva, Simon Gritsch, Patrick Cahan, Ruhong Zhou*, Chunfa Jie, Thomas Donner and Abdel R. Hamad*, A public BCR present in a unique dual-receptor-expressing lymphocyte from type 1 diabetes patients encodes a potent T cell autoantigen, Cell, 177, 1583–1599, 2019\r
\r
Binquan Luan*, Ruhong Zhou, Spontaneous ssDNA stretching on graphene and hexagonal boron nitride in plane heterostructures, Nature Commun. 10, 4610, 2019\r
\r
Xiaomei Wang, Xing Dai, Cen Shi, Jianmei Wan, Mark A. Silver, Linjuan Zhang, Lanhua Chen, Xuan Yi, Bizheng Chen, Duo Zhang, Kai Yang, Juan Diwu*, Jianqiang Wang, Yujie Xu, Ruhong Zhou*, Zhifang Chai, Shuao Wang*, A 3, 2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo, Nature Commun. 10, 2570, 2019\r
\r
Binquan Luan, Guangxue Xu, Mei Feng, Le Cong*,Ruhong Zhou*, Combined Computational–Experimental Approach to Explore the Molecular Mechanism of SaCas9 with a Broadened DNA Targeting Range, J. Am. Chem. Soc. 141, 6545-6552, 2019\r
\r
Daopeng Sheng#, Lin Zhu#, Xing Dai#, Chao Xu, Peng Li, Carolyn Pearce, Chengliang Xiao*, Jing Chen, Ruhong Zhou, Tao Duan, Omar K Farha, Zhifang Chai, Shuao Wang*, Successful Decontamination of 99TcO4- in Groundwater at Legacy Nuclear Sites by a Cationic Metal Organic Framework with Hydrophobic Pockets, Angew. Chem. Intl. Ed., 58, 4968-4972, 2019, DOI 10.1002/anie.201814640, 2019\r
\r
Binquan Luan*, Ruhong Zhou, Atomic-scale Fluidic Diodes Based on Triangular Nanopores in Bilayer Hexagonal Boron Nitride, Nano Lett., 19, 977–982, 2019\r
\r
Liming Wang#, Peiyu Quan#, Serena H Chen#, Wei Bu, Yu-Feng Li, Xiaochun Wu, Junguang Wu, Leili Zhang, Yuliang Zhao, Xiaoming Jiang, Binhua Lin*, Ruhong Zhou*, Chunying Chen*, Stability of Ligands on Nanoparticles Regulating the Integrity of Biological Membranes at the Nano–Lipid Interface, ACS Nano, 13, 8680-8693, 2019\r
\r
Linwei He#, Shengtang Liu#, Long Chen#, Xing Dai, Jie Li, Mingxing Zhang, Fuyin Ma, Chao Zhang, Zaixing Yang*, Ruhong Zhou, Zhifang Chai, Shuao Wang*, Mechanism unravelling for ultrafast and selective 99TcO4−uptake by a radiation-resistant cationic covalent organic framework: a combined radiological experiment and molecular dynamics simulation study, Chem. Sci., 10, 4293-4305, 2019, DOI: 10.1039/C9SC00172G\r
\r
Aleksandr Kakinen*, Yunxiang Sun, Ibrahim Javeda, Ava Faridi, Emily H. Pilkington, Pouya Faridi, Anthony W. Purcell, Ruhong Zhou, Feng Ding, Sijie Lin, Pu Chun Ke*, Thomas P. Davis*, Physical and toxicological profiles of human IAPP amyloids and plaques, Science Bulletin, 64, 26-35, 2019\r
\r
Zonglin Gu#, Lin Zhao#, Cuicui Ge#, Shengtang Liu, Ge Fang, Serena S Chen, Zaixing Yang*, Ruhong Zhou*, Facet-regulated adhesion of double-stranded DNA on palladium surfaces, Nanoscale, 11, 1827-1836, 2019\r
\r
Zonglin Gu#, Wei Song#, Serena H Chen, Baoyu Li, Weifeng Li, Ruhong Zhou*, Defect-assisted protein HP35 denaturation on graphene, Nanoscale, 10, 2019, 10.1039/C9NR01143A\r
\r
Zonglin Gu#, Serena H Chen#, Zhaowen Ding, Wei Song, Wei Wei, Shengtang Liu, Guanghui Ma*, Ruhong Zhou*, Molecular Mechanism of Robust Macrophage Immune Responses Induced by PEGylated Molybdenum Disulfide, Nanoscale, 2019, 10.1039/C9NR04358F\r
\r
Shengtang Liu#, Xiuhua Yin#, Hong Zhou, Bo Zhou, Qiwen Shao, Zaixing Yang*, Ruhong Zhou*, Different Platinum Crystal Surfaces Show Very Distinct Protein Denaturation Capability, Nanoscale, 10, 2019, 10.1039/C9NR03682B\r
\r
Haiying Cui#, Zonglin Gu#, Xiaochen Chen#, Lin Lin, Zegao Wang, Xing Dai, Zaixing Yang, Lei Liu, Ruhong Zhou*, Mingdong Dong*, Stimulating antibacterial activities of graphitic carbon nitride nanosheets with plasma treatment, Nanoscale, 11, 18416-18425, 2019 \r
\r
Baoyu Li, David R Bell, Zonglin Gu, Weifeng Li*, Ruhong Zhou*, Protein WW domain denaturation on defected graphene reveals the significance of nanomaterial defects in nanotoxicity, Carbon, 146, 257-264, 2019\r
\r
Jose Manue Perez-Aguilar, Seung-gu Kang, Leili Zhang, Ruhong Zhou*, Modeling and Structural Characterization of the Sweet Taste Receptor Heterodimer, ACS Chem. Neurosci. 10, 2019, 10.1021/acschemneuro.9b00438\r
\r
Hong Zhou#, Zaixing Yang#, Xin Tian#, Lei Chen, Sangyun Lee, Tien Huynh, Cuicui Ge, Ruhong Zhou*, Lanosterol disrupts the aggregation of amyloid-β peptides, ACS Chem. Neurosci. 10, 4051-4060, 2019\r
\r
Guangxin Duan, Lu Chen, Zhifeng Jing, Phil De Luna, Ling Wen, Leili Zhang, Lin Zhao, Jiaying Xu, Zhen Li, Zaixing Yang, Ruhong Zhou*, Robust Antibacterial Activity of Tungsten Oxide (WO3-x) Nanodots, Chem. Res. Toxico. 32, 1357-1366, 2019\r
\r
Mei Feng, David R Bell, Hongsuk Kang, Qiwen Shao, Ruhong Zhou*, Exploration of HIV-1 fusion peptide–antibody VRC34. 01 binding reveals fundamental neutralization sites, Phys. Chem. Chem Phys., 21, 18569-18576, 2019\r
\r
Hong Zhou, Shengtang Liu, Xiuhua Yin, Zengpeng Li, Zaixing Yang*, Ruhong Zhou*, Molecular Origin of the Stability Difference in Four Shark IgNAR Constant Domains, Biophys. J. 116, 1907-1917, 2019\r
\r
Zhi He, Jingyuan Li, Serena H Chen, Ruhong Zhou*, Surface Inhomogeneity of Graphene Oxide Influences Dissociation of Aβ16-21Peptide Assembly, J. Phys. Chem. B. 123, 2019, 10.1021/acs.jpcb.9b07359\r
\r
Leili Zhang, Binquan Luan, Ruhong Zhou*, Parameterization of Molybdenum Disulfide Interacting with Water Using the Free Energy Perturbation Method, J. Phys. Chem. B. 123, 7243-7252, 2019\r
\r
Leili Zhang, David R Bell, Binquan Luan, Ruhong Zhou*, Exploring the binding mechanism between human profilin (PFN1) and polyproline-10 through binding mode screening, J. Chem. Phys. 150, 015102, 2019\r
\r
Xiuhua Yin, Shengtang Liu, Jose Manuel Perez-Aguilar, Hong Zhou, Qiwen Shao, Zaixing Yang*, Ruhong Zhou*, Different protonated states at the C-terminal of the amyloid-bpeptide modulate the stability of S-shaped protofibril, J. Chem. Phys. 150, 185102, 2019\r
\r
Diego Chowell#, Luc GT Morris#, Claud M Grigg#, Jeffrey K Weber, Robert M Samstein, Vladimir Makarov, Fengshen Kuo, Sviatoslav M Kendall, David Requena, Nadeem Riaz, Benjamin Greenbaum, James Carroll, Edward Garon, David M Hyman, Ahmet Zehir, David Solit, Michael Berger, Ruhong Zhou, Naiyer A Rizvi*, Timothy A Chan*, Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy, Science, 359, 582-587, 2018\r
\r
Ge Fang#, Weifeng Li#, Xiaomei Shen, Jose Manuel Perez-Aguilar, Yu Chong, Xingfa Gao, Zhifang Chai, Chunying Chen*, Cuicui Ge*, and Ruhong Zhou*, Differential Pd-Nanocrystal Facets Demonstrate Distinct Antibacterial Activity against Gram-positive and Gram-negative Bacteria, Nature Communications, 9, 129, 2018\r
\r
Yu Chong#, Xing Dai#, Ge Fang, Renfei Wu, Lin Zhao, Xiaochuan Ma, Xin Tian, Sangyun Lee, Chao Zhang, Chunying Chen, Zhifang Chai, Cuicui Ge*, and Ruhong Zhou*, Palladium Concave Nanocrystals with High-index Facets Accelerate Ascorbate Oxidation in Cancer Treatment, Nature Communications, 9, 4861, 2018\r
\r
Alok V. Joglekar*, Zhe Liu, Jeffrey K. Weber, Yong Ouyang, John D. Jeppson, Won Jun Noh, Pedro A. Lamothe-Molina, Huabiao Chen, Seung-gu Kang, Michael T. Bethune, Ruhong Zhou*, Bruce D. Walker, David Baltimore*, HIV-specific T cell receptors from patients with differential immunologic control are functionally indistinguishable, Proc. Natl. Acad. Sci., 115, 1877-1882, 2018\r
\r
Hongsuk Kang, Zaixing Yang, and Ruhong Zhou*, Lanosterol Disrupts Aggregation of Human γD-Crystallin by Binding to the Hydrophobic Dimerization Interface,J. Am. Chem. Soc. 140, 8479-8486, 2018\r
\r
Daxiang Gui#, Xing Dai#, Zetian Tao#, Tao Zheng, Xiangxiang Wang, Mark A Silver, Jie Shu, Lanhua Chen, Yanlong Wang, Tiantian Zhang, Jian Xie, Lin Zou, Yuanhua Xia, Jujia Zhang, Jin Zhang, Ling Zhao*, Juan Diwu, Ruhong Zhou*, Zhifang Chai, Shuao Wang*, Unique Proton Transportation Pathway in a Robust Inorganic Coordination Polymer Leading to Intrinsically High and Sustainable Anhydrous Proton Conductivity, J. Am. Chem. Soc. 140, 6146-6155, 2018\r
\r
Zonglin Gu#, Leigh D. Plant#, Xuan-Yu Meng*, Jose Manuel Perez-Aguilar, Zegao Wang, Mingdong Dong, Diomedes E. Logothetis*, and Ruhong Zhou*, Exploring the Nanotoxicology of MoS2: A Study on the Interaction of MoS2 Nanoflake and K+ Channels, ACS Nano, 12, 705-717, 2018\r
\r
Binquan Luan* and Ruhong Zhou, Spontaneous Transport of Single-Stranded DNA through Graphene–MoS2 Heterostructure Nanopores,ACS Nano, 12, 3886-3891, 2018\r
\r
Xuan-Yu Meng#, Seung-gu Kang#, Ruhong Zhou*,Molecular Mechanism of Phosphoinositides’ Specificity for the Inwardly Rectifying Potassium Channel Kir2. 2, Chem. Sci.9, 8352-8362, 2018\r
\r
Lu Liu, Shitong Zhang, Lin Zhao, Zonglin Gu, Guangxin Duan, Bo Zhou, Zaixing Yang*, and Ruhong Zhou*, Superior Compatibility of C2N with Human Red Blood Cell Membranes and the Underlying Mechanism, Small, 14, DOI:10.1002/smll.201803509, 2018\r
\r
Binquan Luan* and Ruhong Zhou, Single-File Protein Translocations through Graphene–MoS2 Heterostructure Nanopores, J. Phys. Chem. Lett.9, 3409–3415, 2018\r
\r
Yunjie Zhou#, Yue Sun#, Cheng Zhu, Yang Liu, Xing Dai, Jun Zhong, Qiongyang Chen, He Tian*, Ruhong Zhou*, Zhenhui Kang*, C–O−–K+(Na+) groups in non-doped carbon as active sites for the oxygen reduction reaction, J. Mater. Chem. A 6, 8955-8961, 2018\r
\r
Xia Wang#, Yanlong Wang#, Xing Dai, Mark A Silver, Wei Liu, Yuxiang Li, Zhuanling Bai, Daxiang Gui, Lanhua Chen, Juan Diwu, Ruhong Zhou, Zhifang Chai, Shuao Wang*, Phase transition triggered aggregation-induced emission in a photoluminescent uranyl–organic framework,Chem. Comm. 54, 627-630, 2018\r
\r
Xiaochuan Ma#, Sangyun Lee#, Xingshu Fei, Ge Fang, Tien Huynh, Yu Chong, Zhifang Chai, Cuicui Ge*, Ruhong Zhou*, Inhibition of the proteasome activity by graphene oxide contributes to its cytotoxicity,Nanotoxicology, 12, 185-200, 2018\r
\r
Jing Liu#, Seung-gu Kang#, Peng Wang, Yue Wang, Xiaonan Lv, Ying Liu, Fei Wang, Zonglin Gu, Zaixing Yang, Jeffrey K Weber, Ning Tao, Zhihai Qin, Qing Miao, Chunying Chen*, Ruhong Zhou*, Yuliang Zhao*, Molecular mechanism of Gd@C82(OH)22increasing collagen expression: Implication for encaging tumor, Biomaterials, 152, 24-36, 2018 \r
\r
David R. Bell#, Seung-gu Kang#, Tien Huynh, Ruhong Zhou*, Concentration-dependent binding of CdSe quantum dot on SH3 domain, Nanoscale, 10, 351-358, 2018\r
\r
Serena H. Chen#, Seung-gu Kang#, Judong Luo*, Ruhong Zhou*, Charging Nanoparticles: Increased Binding of Gd@ C82 (OH) 22 Derivatives to Human MMP-9, Nanoscale, 10, 5667-5677, 2018\r
\r
Dongfang Ma, Xuan-Yu Meng*, David R. Bell, Shengtang Liu, Ruhong Zhou*, Inhibition of CYP2C8 by metallofullerenol Gd@C82(OH)22through blocking substrate channels and substrate recognition sites, Carbon 127, 667-675, 2018\r
\r
Wei Liu#, Xing Dai#, Jian Xie#, Mark Silver, Duo Zhang, Yanlong Wang, Yawen Cai, Juan Diwu, Jian Wang, Ruhong Zhou, Zhifang Chai, Shuao Wang*, Highly Sensitive Detecting of UV Radiation using a Uranium Coordination Polymer, ACS Appl. Mater. Interface,10, 4844–4850, 2018\r
\r
Hao Li#, Jian Huang#, Yuxiang Song, Mengling Zhang, Huibo Wang, Fang Lu, Hui Huang, Yang Liu*, Xing Dai, Zonglin Gu, Zaixing Yang, Ruhong Zhou*, Zhenhui Kang*, Degradable carbon dots with broad-spectrum antibacterial activity, ACS Appl. Mater. Interface,10, 26936-26946, 2018\r
\r
Zonglin Gu#, Wei Song#, Zaixing Yang, and Ruhong Zhou*, Metal-Organic Framework as an Efficient Filter for the Removal of Heavy Metal Cations in Water, Phys. Chem. Chem. Phys. 20, 30384 - 30391, 2018\r
\r
Shulin Zhuang, Leili Zhang, Tingjie Zhan, Liping Lu, Lu Zhao, Haifei Wang, Joseph A Morrone, Weiping Liu*, Ruhong Zhou*, The Binding Specificity Determines the Cytochrome P450 3A4-Mediated Enantioselective Metabolism of Metconazole,J. Phys. Chem. B 122, 1176-1184, 2018\r
\r
Jeffrey K Weber, Seung-gu Kang, Ruhong Zhou*, Rare Dissipative Transitions Punctuate the Initiation of Chemical Denaturation in Proteins, Biophys. J. 114, 812-821, 2018\r
\r
Hong Zhou, Shengtang Liu, Qiwen Shao, Dongfang Ma, Zaixing Yang*, Ruhong Zhou*, Mechanism by which DHA inhibits the aggregation of KLVFFA peptides: A molecular dynamics study, J. Chem. Phys. 148, 115102, 2018\r
\r
Hongsuk Kang, Binquan Luan, Ruhong Zhou*, Glassy dynamics in mutant huntingtin proteins, J. Chem. Phys. 149, 072333, 2018