个人简历

张丹，女，医学博士，教授，主任医师，博士生导师。现任浙江大学医学院附属妇产科医院副院长，浙江大学医学院妇产科学院副院长，生殖遗传教育部重点实验室主任助理。浙江省高校生殖健康与生殖安全高水平创新团队带头人，浙江省卫生高层次创新人才、151第二层次人才，浙江省杰青，浙江大学医学院临床拔尖A类人才、“临床名师”。 \r
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教育经历： 1994.9-2001.7 浙江大学医学院临床医学七年制，获医学硕士学位。 2007.9-2011.3 浙江大学医学院妇产科学专业，获医学博士学位。 2011.9-2011.12 英国南安普顿大学附属医院、普尔医院访问学者。 2016.9-2016.12 美国加州大学洛杉矶分校(UCLA) 访问学者。 2017.11-2018.5 哈佛大学医学院附属布里根妇女医院访问学者。 \r
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工作经历： 2001.8-2003.8 浙江大学医学院附属妇产科医院，住院医师； 2003.9-2009.11 浙江大学医学院附属妇产科医院，主治医师； 2009.12-2015.11 浙江大学医学院附属妇产科医院，副主任医师； 2012.4-2014.1 浙江大学医学院附属妇产科医院，生殖科责任医师； 2013.2-2014.1 浙江大学医学院附属妇产科医院，国际合作与交流办公室副主任； 2014.2-至今浙江大学医学院附属妇产科医院，生殖三科主任/党支部书记； 2015.11-至今生殖遗传教育部重点实验室（浙江大学），主任助理 2015.12-至今浙江大学医学院附属妇产科医院，主任医师； 2016.1-2016.12 浙江大学科研院院长助理(挂职)； 2016.6-2017.9 浙江大学医学院附属妇产科医院院长助理； 2017.9-至今浙江大学医学院附属妇产科医院副院长。

研究领域

生殖医学""

近期论文

1. Zhang W, Chen Z, Yin Q, Zhang D, Racowsky C, Zhang Y. Maternal-biased H3K27me3 correlates with paternal-specific gene expression in the human morula. Genes Dev. 2019 Feb. doi:10.1101/gad.323105.118 \r
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2. Guo J, Lv N, Tang J, Zhang X, Peng LH, Du XF, Li S, Luo Q, Zhang D, Chen GD. Associations of blood metal exposure with thyroid hormones in Chinese pregnant women: A cross-sectional study. Environ Int. 2018 Dec;121(Pt 2):1185-1192. \r
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3. Huang Y, Guo J, Lv N, Li S, Wu YQ, Bai RP, Shen J, Chen GD, Zhang D#.Associations of urinary polycyclic aromatic hydrocarbons with age at natural menopause in U.S. women aged 35-65, NHANES 2003-2012. Environ Pollut, 2018;243(Pt B):1878-86. \r
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4. Zhang D*, Liu YF*, Zhang Z*, Lv PP*, Liu Y, Li JY, Wu YQ, Zhang RJ, Huang Y, Xu GF, Qian YQ, Qian YL, Chen SC, Xu CM, Shen J, Zhu LL, Chen K, Zhu B, Ye XQ, Mao YC, Bo XS, Zhou CY, Wang TT, Chen DF, Yang WJ, Tan YJ, Song Y, Zhou DZ, Sheng JZ, Gao HJ, Zhu YM, Li MG, Wu LP, He L, Huang HF. Basonuclin 1 deficiency is a cause of primary ovarian insufficiency. Hum Mol Genet, 2018;27(21):3787-800. \r
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5. Sun X, Guo JH, Zhang D, Chen JJ, Lin WY, Huang Y, Chen H, Huang WQ, Liu Y, Tsang LL, Yu MK, Chung YW, Jiang X, Huang H, Chan HC, Ruan YC. Activation of the epithelial sodium channel (ENaC) leads to cytokine profile shift to pro-inflammatory in labor. EMBO Mol Med. 2018;10(10). \r
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6. Huang Y, Li JY, Zhang F, Liu YF, Xu GF, Guo J, Zhang RJ, Wu YQ, Liu J, Chen K, Zhao W, Wu W, Hu YJ, Chen GD, Zhang D#. Factors affecting the live-birth rate in women with diminished ovarian reserve undergoing IVF-ET. Arch Gynecol Obstet. 2018;298(5):1017-1027. \r
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7. Li K, Li R, Ni Y, Sun PB, Liu Y, Zhang D, Huang HF. Novel distance-progesterone-combined selection approach improves human sperm quality. J Transl Med. 2018 Jul 20;16(1):203. \r
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8. Zhao W, Liu YF, Xu P, Wu YQ, Chen K, Guo XY, Zhang F, Huang Y, Zhu LL, Zhang RJ, Zhang D#. Effects of oestradiol for luteal phase support in fresh embryo transfer cycles: A retrospective cohort study. Clinical Endocrinology(Oxf). 2018 May 12. doi: 10.1111/cen.13740. \r
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9. Chen XJ, Chen F, Lv PP, Zhang D, Ding GL, Hu XL, Feng C, Sheng JZ, Huang HF. Maternal high estradiol exposure alters CDKN1C and IGF2 expression in human placenta. Placenta. 2018; 61:72-79. \r
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10.Liu F, Liu YF, Liu J, Huang Y, Xu GF, Cai J, Chen Y, Wu YQ, Ying YY, Zhang RJ, Zhang D#. Effect of different anesthesia on the reproductive and obstetric outcomes of heterotopic pregnancies. International Journal of Obstetric Anesthesia. 2018（34）, 73–78. \r
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11. Shi Y, Sun Y, Hao C, Zhang H, Wei D, Zhang Y, Zhu Y, Deng X, Qi X, Li H, Ma X, Ren H, Wang Y, Zhang D, Wang B, Liu F, Wu Q, Wang Z, Bai H, Li Y, Zhou Y, Sun M, Liu H, Li J, Zhang L, Chen X, Zhang S, Sun X, Legro RS, Chen ZJ. Transfer of Fresh versus Frozen Embryos in Ovulatory Women. N Engl J Med. 2018 Jan 11;378(2):126-136. \r
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12. Xu GF, Zhou CL, Xiong YM, Li JY, Yu TT, Tian S, Lin XH, Liao Y, Lv Y, Zhang FH, Liu ZW, Shi YY, Shen Y, Sha J, Zhang D, Zhu YM, Sheng JZ, Huang HF. Reduced Intellectual Ability in Offspring of Ovarian Hyperstimulation Syndrome: A Cohort Study. EBioMedicine. 2017;20:263-7. \r
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13.Xu GF，Liao Y，Li JY，Liu YF，Huang Y，Wu YQ，Liu J，Lv PP，Zhang RJ，Zhang D#. Ovarian stimulation perturbs methylation status of placental imprinting genes and reduces blood pressure in the second generation offspring，European Journal of Obstetrics & Gynecology and Reproductive Biology，2017.2.22，211（2017）：140~145. \r
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14.Sun YX*, Zhang YX*, Zhang D*, Xu CM, Chen SC, Zhang JY, Ruan YC, Chen F, Zhang RJ, Qian YQ, Liu YF, Jin LY, Yu TT, Xu HY, Luo YQ, Liu XM, Sun F, Sheng JZ, Huang HF. XCI-escaping gene KDM5C contributes to ovarian development via downregulating miR-320a. Hum Genet. 2017, 136(2):1-13. \r
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15.Lv PP, Tian S, Feng C, Li JY, Yu DQ, Jin L, Shen Y, Yu TT, Meng Y, Ding GL, Jin M, Chen XJ, Sheng JZ, Zhang D#, Huang HF#.Maternal High Estradiol Exposure is Associated with Elevated Thyroxine and Pax8 in Mouse Offspring. Sci Rep. 2016 Nov 9;6:36805. \r
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16.Zhu L, Zhang Y, Liu Y, Zhang R, Wu Y, Huang Y, Liu F, Li M, Sun S, Xing L, Zhu Y, Chen Y, Xu L, Zhou L, Huang H#, Zhang D#.Maternal and Live-birth Outcomes of Pregnancies following Assisted Reproductive Technology: A Retrospective Cohort Study.Sci Rep. 2016 Oct 20;6:35141. \r
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17.Zhang D*#, Xu GF*, Zhang RJ, Zhu YM, Gao HJ, Zhou C, Sheng JZ, Huang HF#. Decreased expression of aquaporin 2 is associated with impaired endometrial receptivity in controlled ovarian stimulation. ReprodFertil Dev. 2016, 28(4): 499-506. \r
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18.Song Y, Wang ES, Xing LL, Shi S, Qu F, Zhang D, Li JY, Shu J, Meng Y, Sheng JZ, Zhou JH, Huang HF. Follicle-Stimulating Hormone Induces Postmenopausal Dyslipidemia Through Inhibiting Hepatic Cholesterol Metabolism. J Clin Endocrinol Metab. 2016; 101: 254–263. \r
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19.Liu AX, Zhang D, Zhu YM, Gao HJ, Jiang JY, Hu XL, Lv PP, Leung PC, Huang HF. Impact of Axis of GHRH and GHRH Receptor on Cell Viability and Apoptosis of the Placental Choriocarcinoma Cell Line. CurrMol Med. 2016;16(3):299-311.