个人简历

学习经历\r
2006.9-2010.3 德国耶拿大学生物与药学学院 理学博士\r
2004.9-2006.6 浙江大学生命科学学院 理学硕士\r
2000.9-2004.6 浙江大学生命科学学院 理学学士\r
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工作经历\r
2015.1-至今 浙江大学化学工程与生物工程学院 副教授\r
2013.8-2014.12 浙江大学化学工程与生物工程学院 讲师\r
2013.2-2013.8 新加坡科技研究局化学与工程科学研究院 Scientist\r
2010.8-2013.2 新加坡国立大学化学与生物分子工程系 博士后研究员

研究领域

"""""代谢工程\r
合成生物学\r
蛋白质工程"

近期论文

Jiawei Ge, Xiaohong Yang, Hongwei Yu, Lidan Ye*. High-yield whole cell biosynthesis of Nylon 12 monomer with self-sufficient supply of multiple cofactors. Metabolic Engineering, 2020, DOI: 10.1016/j.ymben.2020.09.006\r
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Ze-Hui Shao, Bing-Mei Su, Sheng-Li Yang*, Li-Dan Ye*, Hong-Wei Yu*. Rational design of the carbonyl reductase EbSDR8 for efficient biosynthesis of enantiopure (R)-3-Chloro-1-phenyl-1-propanol. Applied Microbiology and Biotechnology, 2020, DOI: 10.1007/s00253-020-10904-5\r
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Xiaohong Yang, Lian Wu, Aipeng Li, Lidan Ye*, Jiahai Zhou*, Hongwei Yu*. Engineering of Decameric D-fructose-6-phosphate Aldolase A by Combinatorial Modulation of Inter- and Intra-subunit Interactions. Chemical Communications, 2020, 56, 7561-7564\r
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Bing-Mei Su, Ai-Peng Li, Ze-Hui Shao, Muhammad Naeem, Juan Lin*, Li-Dan Ye*, Hong-Wei Yu*. Rational Design of Dehydrogenase/reductases Based on Comparative Structural Analysis of Prereaction-state and Free-state Simulations for Efficient Asymmetric Reduction of Bulky Aryl Ketones. ACS Catalysis, 2020, 10(1): 864-876\r
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Yaoyao Zhang, Jin Wang*, Xianshuang Cao, Wei Liu, Hongwei Yu, Lidan Ye*. High-level production of linalool by engineered Saccharomyces cerevisiae harboring dual mevalonate pathways in mitochondria and cytoplasm. Enzyme and Microbial Technology, 2020, 134: 109462\r
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Pingping Zhou*, Yi Du, Nannan Xu, Chunlei Yue, Lidan Ye*. Improved linalool production in Saccharomyces cerevisiae by combining directed evolution of linalool synthase and overexpression of the complete mevalonate pathway. Biochemical Engineering Journal, 2020, 161:107655\r
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Muhammad Naeem, Aipeng Li, Muhammad Adnan Younis, Bin Shen, Lidan Ye, Hongwei Yu*. Asymmetric Bioreduction of 4-hydroxy-2-butanone by Carbonyl Reductases PFODH and CpSADH Delivers 1,3-butanediol Enantiomers with Excellent R- and S-enantioselectivity. Biotechnology and Bioprocess Engineering, 2019, 24:972-980\r
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Ling Jiang, Lidan Ye, Jiali Gu, Weike Su, Wenting Ye. Mechanochemical enzymatic synthesis of 1,4-dihydropyridine calcium antagonists and derivatives. Journal of Chemical Technology and Biotechnology, 2019, 94: 2555-2560\r
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Xiafen Wu, Shengli Yang*, Hongwei Yu*, Lidan Ye, Bingmei Su, Zehui Shao. Improved enantioselectivity of E. coli BioH in kinetic resolution of methyl (S)-3-cyclohexene-1-carboxylate by combinatorial modulation of steric and aromatic interactions. Bioscience, Biotechnology, and Biochemistry, 2019, 83(7): 1263-1269\r
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Wenya Wang*, Sisi Su, Shizhuo Wang, Lidan Ye*, Hongwei Yu*. Significantly improved catalytic efficiency of caffeic acid O-methyltransferase towards N-acetylserotonin by strengthening its interactions with the unnatural substrate's terminal structure. Enzyme and Microbial Technology , 2019, 125:1-5\r
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Pingping Zhou, Min Li, Bin Shen, Zhen Yao, Qi Bian, Lidan Ye*, and Hongwei Yu. Directed Coevolution of β-Carotene Ketolase and Hydroxylase and Its Application in Temperature-Regulated Biosynthesis of Astaxanthin. Journal of Agricultural and Food Chemistry, 2019, 67 (4), 1072–1080\r
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Muhammad Naeem, Ashfaq UrRehman, Bin Shen, Lidan Ye, Hongwei Yu*. Semi-rational engineering of carbonyl reductase YueD for efficient biosynthesis of halogenated alcohols with in situ cofactor regeneration. Biochemical Engineering Journal, 2018, 137, 62-70\r
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Huijuan Cao, Pengyun Huang, Yuxin Yan, Yongkai Shi, Bo Dong, Xiaohong Liu, Lidan Ye, Fucheng Lin, Jianping Lu*.The basic helix-loop-helix transcription factor Crf1 is required for development and pathogenicity of the rice blast fungus by regulating carbohydrate and lipid metabolism: Transcription factor Crf1 in Pyricularia oryzae. Environmental Microbiology, 2018, 20(9), 3427-3441\r
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Haiping Jiang, Sujuan Wang, Xuefei Zhou, Liying Wang, Lidan Ye, Zhuxian Zhou, Jianbin Tang, Xiangrui Liu*, Lisong Teng, Youqing Shen. New path to treating pancreatic cancer: TRAIL gene delivery targeting the fibroblast-enriched tumor microenvironment. Journal of Controlled Release, 2018, 286: 254-263\r
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Zhen Yao, Pingping Zhou, Bingmei Su, Sisi Su, Lidan Ye*, Hongwei Yu*. Enhanced isoprene production by reconstruction of metabolic balance between strengthened precursor supply and improved isoprene synthase in Saccharomyces cerevisiae. ACS Synthetic Biology, 2018, 7(9):2308-2316\r
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Pingping Zhou, Wenping Xie, Zhen Yao, Yongqiang Zhu, Lidan Ye, Hongwei Yu. Development of a temperature-responsive yeast cell factory using engineered Gal4 as a protein switch. Biotechnology and Bioengineering, 2018, 115(5):1321-1330\r
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Lidan Ye, Chengcheng Yang, Hongwei Yu*. From molecular engineering to process engineering: Development of high-throughput screening methods in enzyme directed evolution. Applied Microbiology and Biotechnology, 2018, 102(2):559-567\r
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Pingping Zhou, Wenping Xie, Aipeng Li, Fan Wang, Zhen Yao, Qi Bian, Yongqiang Zhu, Hongwei Yu, Lidan Ye*. Alleviation of metabolic bottleneck by combinatorial engineering enhanced astaxanthin synthesis in saccharomyces cerevisiae. Enzyme and Microbial Technology, 2017, 100: 28-36\r
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Fan Wang, Xiaomei Lv, Wenping Xie, Pingping Zhou, Yongqiang Zhu, Zhen Yao, Chengcheng Yang, Xiaohong Yang, Lidan Ye*, Hongwei Yu* Combining Gal4p-mediated expression enhancement and directed evolution of isoprene synthase to improve isoprene production in Saccharomyces cerevisiae, Metabolic Engineering, 2017, 39:257-266\r
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Lidan Ye1, Xiaomei Lv1, Hongwei Yu*Assembly of Biosynthetic Pathways in Saccharomyces cerevisiae Using A Ready-to-use Marker Recyclable Integrative Plasmid Toolbox, Frontiers of Chemical Science and Engineering, 2017, 11(1): 126-132