个人简历

教育背景 \r
1999年1月— 2002年1月: 在新加坡国立大学化学与环境工程系攻读博士学位，并于2002年10月获工学博士学位 \r
1995年9月—1998年7月: 在清华大学核能技术研究院学习，获工学硕士学位 \r
1990年9月—1995年7月: 在清华大学化学工程系学习，获工学学士学位\r
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工作经历 \r
1998年7月—1998年12月：清华紫光英力公司，研发工程师\r
2002年2月— 2005年1月：新加坡国立大学化学及过程工程中心，博士后研究员\r
2005年2月—2007年6月：新加坡南洋理工大学化学与生物分子工程系，博士后研究员。其间2005年9月—2006年3月，在美国加州理工学院作博士后, 进行酶的定向进化研究\r
2007年7月—：浙江大学化学工程与生物工程学院，教授，博导

研究领域

"""""酶定向进化及理性设计\r
酶催化手性药物拆分及合成的研究\r
代谢工程与合成生物学"

近期论文

Shen Bin, Zhou Pingping, Jiao Xue, Yao Zhen, Ye Lidan, Yu Hongwei, Fermentative production of Vitamin E tocotrienols in Saccharomyces cerevisiae under cold-shock-triggered temperature control, Nature Communications 11,5155,2020.\r
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Yang XH, et al.,Engineering of Decameric D-fructose-6-phosphate Aldolase A by Combinatorial Modulation of Inter- and Intra-subunit Interactions, Chemical Communications, 2020.\r
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Zhang, YY ; Wang, J ; Cao, XS ; Liu, W ; Yu, HW ; Ye, LDHigh-level production of linalool by engineered Saccharomyces cerevisiae harboring dual mevalonate pathways in mitochondria and cytoplasm ENZYME AND MICROBIAL TECHNOLOGY 134, 109462, 2020\r
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Su Bingmei et al.,Rational Design of Dehydrogenase Reductases Based on Comparative Structural Analysis of Prereaction-State and Free-State Simulations for Efficient Asymmetric Reduction of Bulky Aryl Ketones, ACS CATALYSIS 卷: 10 期: 1 页: 864-876 出版年: JAN 3 2020\r
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Naeem, Muhammad; Li, Aipeng;Asymmetric Bioreduction of 4-hydroxy-2-butanone by Carbonyl Reductases PFODH and CpSADH Delivers 1,3-butanediol Enantiomers with Excellent R- and S-enantioselectivity. BIOTECHNOLOGY AND BIOPROCESS ENGINEERING 卷: 24 期: 6 页: 972-980 出版年: DEC 2019\r
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Wu, XF ; Yang, SL ; Yu, HW ; Ye, LD; Su, BM ; Shao, ZH, Improved enantioselectivity of E. coli BioH in kinetic resolution of methyl (S)-3-cyclohexene-1-carboxylate by combinatorial modulation of steric and aromatic interactions BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 卷: 83 期: 7 页: 1263-1269 出版年: JUL 3 2019\r
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Wang, WY ; Su, SS ; Wang, SZ ; Ye, LD ; Yu, HW Significantly improved catalytic efficiency of caffeic acid O-methyltransferase towards N-acetylserotonin by strengthening its interactions with the unnatural substrate's terminal structure. ENZYME AND MICROBIAL TECHNOLOGY 卷: 125 页: 1-5 出版年: JUN 2019\r
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Pingping Zhou, Min Li, Bin Shen, Zhen Yao, Qi Bian, Lidan Ye*, and Hongwei Yu, Directed co-evolution of #-carotene ketolase and hydroxylase and its application in temperature-regulated biosynthesis of astaxanthin. Journal of agriculture and food chemistry.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 卷: 67 期: 4 页: 1072-1080 出版年: JAN 30 2019\r
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Semi-rational engineering of carbonyl reductase YueD for efficient biosynthesis of halogenated alcohols with in situ cofactor regeneration Author(s): Naeem, Muhammad; Rehman, Ashfaq Ur; Shen, Bin; et al. Source: BIOCHEMICAL ENGINEERING JOURNAL Volume: 137 Pages: 62-70 Published: SEP 15 2018\r
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Enhanced Isoprene Production by Reconstruction of Metabolic Balance between Strengthened Precursor Supply and Improved Isoprene Synthase in Saccharomyces cerevisiae Author(s): Yao, Zhen; Zhou, Pingping; Su, Bingmei; et al. Source: Acs Synthetic Biology Volume: 7 Issue: 9 Pages: 2308-2316 Published: SEP 2018\r
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From molecular engineering to process engineering: development of high-throughput screening methods in enzyme directed evolution Author(s): Ye, Lidan; Yang, Chengcheng; Yu, Hongwei Source: Applied Microbiology and Biotechnology Volume: 102 Issue: 2 Pages: 559-567 Published: JAN 2018\r
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Development of a temperature-responsive yeast cell factory using engineered Gal4 as a protein switch Author(s): Zhou, Pingping; Xie, Wenping; Yao, Zhen; et al. Source: Biotechnology and Bioengineering Volume: 115 Issue: 5 Pages: 1321-1330 Published: MAY 2018\r
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Zhu Yongqiang et al., Yu Hongwei*, Enhanced synthesis of Coenzyme Q10 by reducing the competitive production of carotenoids in Rhodobacter sphaeroides, Biochemical Engineering Journal, Volume: 125 Pages: 50-55 Published: SEP 15 2017.\r
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Zhu Yongqiang et al., Yu Hongwei*, Synergic Regulation of Redox Potential and Oxygen Uptake to Enhance Production of Coenzyme Q10 in Rhodobacter sphaeroides, Enzyme and Microbial Technology Volume: 101 Pages: 36-43 Published: JUN 2017.\r
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Zhou Pingping et al., Ye Lidan*, Yu Hongwei, Alleviation of metabolic bottleneck by combinatorial engineering enhanced astaxanthin synthesis in Saccharomyces cerevisiae, Enzyme and Microbial Technology Volume: 100 Pages: 28-36 Published: MAY 2017.\r
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Wang Fan, et al., Ye Lidan*, Yu Hongwei*, Combining Gal4p-mediated expression enhancement and directed evolution of isoprene synthase to improve isoprene production in Saccharomyces cerevisiae, Metabolic Engineering, Volume: 39 Pages: 257-266 Published: JAN 2017.\r
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Yang Xiaohong, et al., Yu Hongwei* Engineering of D-Fructose-6-Phosphate Aldolase A for Improved Activity towards Cinnamaldehyde, Catalysis Science & Technology, Volume: 7 Issue: 2 Pages: 382-386 Published: 2017.\r
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Lv Xiaomei, et al., Yu Hongwei*, Assembly of Biosynthetic Pathways in Saccharomyces cerevisiae Using A Ready-to-use Marker Recyclable Integrative Plasmid Toolbox, Frontiers of Chemical Science and Engineering, Volume: 11 Issue: 1 Pages: 126-132 Published: MAR 2017.\r
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Yang ChengCheng, et al., Yu Hongwei*, Directed evolution of mandelate racemase by a novel high-throughput screening method, Applied Microbiology and Biotechnology, Volume: 101 Issue: 3 Pages: 1063-1072 Published: FEB 2017.\r
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Xiaomei Lv, Fan Wang, Pingping Zhou, Lidan Ye, Wenping Xie, Haoming Xu & Hongwei Yu* Dual regulation of cytoplasmic and mitochondrial acetyl-CoA utilization for improved isoprene production in Saccharomyces cerevisiae, Nature Communications, Volume: 7 Published: SEP 2016.