个人简历

王宝俊，浙江大学化学工程与生物工程学院求是教授、博士生导师，现任浙江大学杭州国际科创中心生物与分子智造研究院副院长、合成生物学研究所所长。2005获浙江大学生物医学工程学士学位，2011年获英国帝国理工学院生物工程博士学位。2013年加入英国爱丁堡大学任合成生物学助理教授，2019年晋升终身教授，2022年1月加入浙江大学化学工程与生物工程学院生物工程研究所任求是教授。长期从事合成生物学使能技术开发、基因线路工程化设计及在生物传感、生物制造等领域的创新应用方向的科研和教学工作。近三年以通讯作者发表重要学术论文20余篇（包括Nature Chem Biol, Nature Commun 等6篇Nature子刊论文），主持英国研究创新委员会、比尔盖茨基金会、英国国防部和美国海军研究全球计划署等二十余项研究基金（总额约6000万人民币)，在研项目合作企业包括微软、华为等国际知名技术公司。曾获得的重要奖项有：2015年盖茨基金会全球大挑战探索基金奖；2016年英国生物技术与科学基金会新研究员奖、维康基金会科学种子基金奖；2019年英国自然科学基金会杰出青年科学基金奖(全英仅41人)；2020年入选英国皇家化学学会会士(FRSC)。

研究领域

"""""合成生物学使能技术与工具开发（内含肽、CRISPR基因编辑与调控等）\r
基因元器件的挖掘、改造、标准化及正交化设计\r
基因线路设计（包括工程化、规模化、生物自动化设计等）\r
生物传感（面向环境、健康需求）与智能生物诊疗\r
生物计算与生物制造（基于人工细胞或无细胞表达系统等）"

近期论文

Liu Y, Pinto F, Wan X, Z Yang, Peng S, Li M, J Cooper, Xie Z, French C and Wang B, “Reprogrammed tracrRNAs enable repurposing of RNAs as crRNAs and sequence-specific RNA biosensors”, Nature Communications, 2022, 13, 1937 doi \r
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Liu Y, Pinto F, Wan X, Peng S, Li M, Xie Z, French C and Wang B, “Reprogrammed tracrRNAs enable repurposing RNAs as crRNAs and detecting RNAs”, bioRxiv, 2021 doi \r
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Ho T, Shao Y, Lu Z, Savilahti H, Menolascina F, Wang L, Dalchau N and Wang B, “A systematic approach to inserting split inteins for Boolean logic gate engineering and basal activity reduction”, Nature Communications, 2021, 12, 2200 doi pdf (Reported by PhysOrg, Edinburgh BioSciences News, UoE SynthSys News and BioArt among others)\r
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Saltepe B, Wang L and Wang B, “Synthetic biology enables field-deployable biosensors for water contaminants”, Trends in Analytical Chemistry, 2022, 146, 116507 doi \r
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Belkin S and Wang B, “Sense and sensibility: of synthetic biology and the redesign of bioreporter circuits”, Microbial Biotechnology, 2022, 15(1), 103-106 doi pdf\r
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Lopreside A, Montali L, Wang B, Tassoni A, Ferri M, Calabretta M and Michelini E, “Orthogonal paper biosensor for mercury(II) contamination combining bioluminescence and colorimetric smartphone detection”, Biosensors and Bioelectronics, 2021, 194, 113569 doi pdf\r
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Chen JX, Wang B, Thompson I, Huang EW, “Rational design and characterisation of nitric oxide biosensors in E. coli Nissle 1917 and mini SimCells”, ACS Synthetic Biology, 2021, 10(10), 2566–2578. doi pdf\r
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Wan X, Saltepe B, Yu L and Wang B, “Programming living sensors for environment, health and biomanufacturing”, Microbial Biotechnology, 2021, 14(6): 2334-2342. doi pdf\r
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Gale G, Wang B and McCormick A, “Evaluation and comparison of the efficiency of transcription terminators in different cyanobacterial species', Frontiers in Microbiology, 2021, 11:624011 doi pdf\r
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Wan X, Pinto F, Yu L and Wang B, “Synthetic protein-binding DNA sponge as a tool to tune gene expression and mitigate protein toxicity”, Nature Communications, 2020, 11, 5961 doi pdf (Reported by Nature Research Bioengineering Blog, BioArt, Zhihu-Regensis and UoE SynthSys News among others) \r
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Pinto F, Thornton E and Wang B, “An expanded library of orthogonal split inteins enables modular multi-peptide assemblies”, Nature Communications, 2020, 11, 1529 doi pdf (Reported by Edinburgh BioSciences News, Nature Research Bioengineering Blog and BioArtReports among others)\r
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Liu Y and Wang B, “A novel eukaryote-like CRISPR activation tool in bacteria: features and capabilities”, BioEssays, 2020, 42(6), 1900252 doi pdf (Featured as Journal Front Cover Article)\r
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Hicks M, Bachmann T and Wang B, “Synthetic biology enables programmable cell-based biosensors”, ChemPhysChem, 2020, 21, 132–144 doi pdf (Featured as Journal Front Cover Article; ChemPhysChem Top Downloaded Paper)\r
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Liu Y, Wan X and Wang B, 'Engineered CRISPRa enables programmable eukaryote-like gene activation in bacteria', Nature Communications, 2019, 10, 3693 doi pdf (Reported by The National, The National Tribune, Drug Target Review, PhysOrg, Science Daily, BioArt, Zhihu-Regensis, Edinburgh University News and UoE SynthSys News among others)\r
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Wan X, Volpetti F, Petrova E, French C, Maerkel S and Wang B, 'Cascaded amplifying circuits enable ultrasensitive cellular sensors for toxic metals', Nature Chemical Biology, 2019, 15(5):540–548 doi pdf (Reported by Yahoo News, E&T Magazine, PhysOrg, Science Daily, Microbiologist, BioArt, Edinburgh Friends, Edinburgh University News and UoE BioSciences News among others)\r
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Lopreside A, Wan X, Michelini E, Roda A and Wang B, “Comprehensive profiling of diverse genetic reporters with application to whole-cell and cell-free biosensors”, Analytical Chemistry, 2019, 91, 15284−15292 doi pdf\r
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Gale G, Schiavon A, Mills L, Wang B, Lea-Smith D and McCormick A, “Emerging species and genome editing tools: future prospects in cyanobacterial synthetic biology”, Microorganisms, 2019, 7(10):409 doi pdf\r
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Gale G, Schiavon A, Puzorjov A, Wang B and McCormick A, “Genetic modification of cyanobacteria by conjugation using the modular cloning CyanoGate toolkit”, Journal of Visualized Experiments, 2019, (152), e60451 doi pdf\r
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Vasudevan R, Gale G, Schiavon A, Puzorjov A, Malin J, Gillespie M, Vavitsas K, Zulkower V, Wang B, Howe C, Lea-Smith D and McCormick A, 'CyanoGate: A modular cloning suite for engineering cyanobacteria based on the plant MoClo syntax', Plant Physiology, 2019, 180(1):39-55 doi pdf\r
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Liu Q, Schumacher J, Wan X, Lou C and Wang B, “Orthogonality and burdens of heterologous AND gate gene circuits in E. coli”, ACS Synthetic Biology, 2018, 7(2):553-564 doi pdf (Featured in Edinburgh SynthSys Centre News; among Most Read Articles of ACS Synthetic Biology)