个人简历

1982年毕业于浙江医科大学医学系，1987年获医学硕士学位。1990年获联邦德国吕贝克医科大学博士学位。中华医学会病理学分会候任主任委员、中国医师协会病理医师分会副会长、浙江大学病理学和病理生理学系主任、国家重点（培育）学科、浙江省重点学科—病理学及省重点实验室（浙江省疾病蛋白质组学重点实验室）学术带头人。国家新世纪百千万人才工程培养对象。 国家科技支撑计划项目“代谢综合征的早期识别和干预技术研究”首席科学家。国际期刊Clinica Chimica Acta 、Open Proteomics Journal和Pathology and Laboratory Medicine International的编委。 在国际上首次发现胰岛素样生长因子结合蛋白-相关蛋白1（IGFBP-rP1）是一个在结直肠癌中高表达的基因，并且其表达与病人血糖密切相关。后续的研究证明IGFBP-rP1是一个抑癌基因，其表达受该基因第一外显子的甲基化调控；发现RegIV是一个在结直肠肿瘤中高表达的新基因，可能是一个预警腺瘤癌变的生物学标志；分离鉴定了新神经内分泌标志物促泌素，开发了用于神经内分泌癌诊断和治疗监控的外周血促泌素检测方法，并已用于临床病理诊断；在国内最早开展实体瘤微卫星不稳定性研究，建立了系列的研究方法，为将微卫星不稳定性检测用于临床提供了可能；在生物信息学与分子病理学结合应用上进行了开拓性的工作。

研究领域

肿瘤病理与分子病理""

近期论文

1.Lin J, Lai M, Huang Q, Ma Y, Cui J, Ruan W. Methylation patterns of IGFBP7 in colon cancer cell lines are associated with levels of gene expression. The Journal of pathology 2007;212: 83-90. IF 5.423 \r
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2.Lu B, Xu J, Zhu Y, Zhang H, Lai M. Systemic analysis of the differential gene expression profile in a colonic adenoma-normal SSH library. Clinica chimica acta; international journal of clinical chemistry 2007;378: 42-7. IF 2.601 \r
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3.MD L, Xujing. Ribosomal proteins and colorectal cancer. Current Genomics 2007;8: 43-9. IF 0.573 \r
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4.Ruan W, Lai M. Actin, a reliable marker of internal control? Clinica chimica acta; international journal of clinical chemistry 2007;385: 1-5. IF 2.601 \r
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5.Ruan W, Xu E, Xu F, et al. IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesis. Cancer biology & therapy 2007;6: 354-9. IF 2.873 \r
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6.Wang Y, Ma Y, Lu B, Xu E, Huang Q, Lai M. Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study. Exp Biol Med (Maywood) 2007;232: 1152-9. IF 1.979 \r
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7.Xu E, Xia X, Lu B, et al. Association of matrix metalloproteinase-2 and -9 promoter polymorphisms with colorectal cancer in Chinese. Mol Carcinog 2007. IF 3.194 \r
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8.Xu F, Wang F, Di M, et al. Classification based on the combination of molecular and pathologic predictors is superior to molecular classification on prognosis in colorectal carcinoma. Clin Cancer Res 2007;13: 5082-8. IF 6.25 \r
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9.Ye F, Chen Y, Knosel T, et al. Decreased expression of insulin-like growth factor binding protein 7 in human colorectal carcinoma is related to DNA methylation. Journal of cancer research and clinical oncology 2007;133: 305-14. IF 2.366 \r
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10.Zhu Y, Lai M, Yang H, et al. Genotypes, haplotypes and diplotypes of XPC and risk of bladder cancer. Carcinogenesis 2007;28: 698-703. IF 5.406 \r
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11.Zhu YM, Huang Q, Lin J, Hu Y, Chen J, Lai MD. Expression of human DNA methyltransferase 1 in colorectal cancer tissues and their corresponding distant normal tissues. International journal of colorectal disease 2007;22: 661-6. IF 1.918 \r
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12.Kang L, Lu B, Xu J, Hu H, Lai M. Downregulation of Kruppel-like factor 9 in human colorectal cancer. Pathol Int 2008;58: 334-8. IF 1.371 \r
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13.Lu B, Fang Y, Xu J, et al. Analysis of SOX9 expression in colorectal cancer. Am J Clin Pathol 2008;130: 897-904. IF 2.629 \r
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14.Lu B, Xu J, Chen J, Yu J, Xu E, Lai M. TaqMan low density array is roughly right for gene expression quantification in colorectal cancer. Clinica chimica acta; international journal of clinical chemistry 2008;389: 146-51. IF 2.601 \r
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15.Ma Y, Lu B, Ruan W, et al. Tumor suppressor gene insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) induces senescence-like growth arrest in colorectal cancer cells. Exp Mol Pathol 2008;85: 141-5. IF 1.822 \r
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16.Teng X, Yu X, Wang G, Xu L, Lai M. Sclerosing angiomatoid nodular transformation of the spleen. Anal Quant Cytol Histol 2008;30: 125-32. IF 0.989 \r
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17.Xu J, Lu B, Xu F, et al. Dynamic down-regulation of Kruppel-like factor 4 in colorectal adenoma-carcinoma sequence. Journal of cancer research and clinical oncology 2008;134: 891-8. IF 2.366 \r
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18.Xue H, Lu B, Lai M. The cancer secretome: a reservoir of biomarkers. J Transl Med 2008;6: 52. IF 2.935