个人简历

高钟镐，男，博士，1963年1月出生，朝鲜族，现任中国医学科学院北京协和医学院药物研究所研究员、博士研究生导师。\r
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1994年留学韩国首尔国立大学（Seoul National University），师从韩国药学会会长金钟国教授攻读博士学位，1998年毕业获得药学博士，主要研究方向为生物物理药剂学；2001-2003年进入美国哈佛大学和东北大学进行博士后研究，师从美国药物控释学会会长Vladimir P Torchilin教授，主要从事药物控释和靶向制剂研究。1998年2月至2000年1月任职于韩国首尔国立大学，担任助理研究员；2000年1月至2001年1月就职于韩国忠北国立大学，担任研究员职务；2003年3月至2008年2月，任职于美国犹他大学，担任生物工程系和药学系助理教授。2008年2月，作为国际高端人才被中国医学科学院北京协和医学院药物研究所人才引进作为药剂学科带头人，担任研究员和博士生导师

研究领域

"""""主要从事纳米释药系统、肿瘤靶向制剂和核酸递送载体等研究工作"

近期论文

Wei Huang#, Liqing Chen#, Lin Kang#, Mingji Jin, Ping Sun, Xin Xin, Zhonggao Gao*, You Han Bae. Nanomedicine-based combination anticancer therapy between nucleic acids and small-molecular drugs. Advanced Drug Delivery Reviews, 2017, In press, http://dx.doi.org/10.1016/j.addr.2017.06.004. (IF：11.764)\r
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Bo Fan, Lin Kang, Liqing Chen, Ping Sun, Mingji Jin, Qiming Wang, You Han Bae, Wei Huang*, Zhonggao Gao*. Systemic siRNA Delivery With a Dual pH-Responsive and Tumor-targeted Nanovector for Inhibiting Tumor Growth and Spontaneous Metastasis in Orthotopic Murine Model of Breast Carcinoma. Theranostics, 2017, 7(2):357-376. (IF：8.712)\r
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Xiao-DanYan, Qi-Ming Wang, Cai Tie, Hong-Tao Jin, Yan-Xing Han, Jin-Lan Zhang, Xiao-MingYu, Qi Hou, Piao-Piao Zhang, Ai-Ping Wang, Pei-Cheng Zhang*, Zhong-Gao Gao*, Jian-Dong Jiang*. Polydatin protects the respiratory system from PM2.5 exposure. Scientific Reports, 2017, 7:40030. DOI: 10.1038/srep40030. (IF：4.259)\r
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Ping Sun, Wei Huang*, Lin Kang, Mingji Jin, Bo Fan, Hongyan Jin, Qiming Wang, Zhonggao gao*. siRNA-loaded poly(histidine-arginine)6-modifed chitosan nanoparticle with enhanced cell-penetrating and endosomal escape capacities for suppressing breast tumor metastasis. International Journal of Nanomedicine, 2017, 12:3221–3234. (IF：4.300)\r
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Lin Kang, Bo Fan, Ping Sun, Wei Huang, Mingji Jin, Qiming Wang, Zhonggao Gao*. An effective tumor-targeting strategy utilizing hypoxia-sensitive siRNA delivery system for improved anti-tumor outcome. Acta Biomaterialia, 2016, 44:341-354. (IF：6.319)\r
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Ping Sun, Wei Huang, Mingji Jin, Qiming Wang, Bo Fan, Lin Kang, Zhonggao gao*. Chitosan-based nanoparticles for survivin targeted siRNA delivery in breast tumor therapy and preventing its metastasis. International Journal of Nanomedicine, 2016,11:4931-4945. (IF：4.300)\r
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Liqing Chen, Wei Huang*, Zhonggao Gao*, Weishuo Fang, Mingji Jin. Lx2-32c-loaded polymeric micelles with small size for intravenous drug delivery and inhibitory effect on tumor growth and metastasis against clinically associated 4T1 murine breast cancer. International Journal of Nanomedicine, 2016, 11: 5457-5472. (IF：4.300)\r
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Shan Liu#, Wei Huang#, Mingji Jin, Bo Fan, Guimin Xia, Zhonggao Gao*. Inhibition of murine breast cancer growth and metastasis by survivin-targeted siRNA using disulfide cross-linked linear PEI. European Journal of Pharmaceutical Sciences, 2016, 82:171–182. (IF：3.756)\r
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Li-qing Chen#, Zhe-ming Zhang#, Wei Huang*, Zhong-gao Gao*, Wei-shuo Fang, Ming-ji Jin, Lian Yu. Inhibiting the proliferation, migration and invasion of triple negative breast cancer cells through anti-tumor human serum albumin nanoparticles loading Aziditaxel as a novel taxane derivative. Pharmazie, 2017, 72(3):152-160. (IF：1.126)\r
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Lin Kang, Zhonggao Gao*, Wei Huang, Mingji Jin, Qiming Wang. Nanocarrier-mediated co-delivery of chemotherapeutic drugs and gene agents for cancer treatment. Acta Pharmaceutica Sinica B, 2015, 5(3): 169-175.\r
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Qiming Wang, Zhonggao Gao*, Shan Liu, Bo Fan, Lin Kang, Wei Huang, Mingji Jin. Hybrid polymeric micelles based on bioactive polypeptides as pH-responsive delivery systems against melanoma. Biomaterials, 2014, 35(25): 7008-7021. (IF：8.557)\r
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Shan Liu, Wei Huang, Mingji Jin, Qiming Wang, Ganlin Zhang, Xiaomin Wang, Shuai Shao, Zhonggao Gao*. Efficient gene delivery of alkylated low molecular weight polyethylenimine through gemini surfactant-like effect. International Journal of Nanomedicine, 2014, 9(1): 3567-3581. (IF：4.383)\r
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Feifei Yang#, Wei Huang#, Yunfei Li, Shan Liu, Mingji Jin, Yuli Wang, Lihua Jia, Zhonggao Gao*. Anti-tumor effects in mice induced by Survivin-targeted siRNA delivered through polysaccharide nanoparticles. Biomaterials, 2013, 34(22): 5689-5699. (IF：8.312)\r
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Yunfei Li, Mingji Jin, Shuai Shao, Wei Huang, Feifei Yang, Wei Chen, Shenghua Zhang, Guimin Xia, Zhonggao Gao*. Small-sized polymeric micelles incorporating docetaxel suppress distant metastases in the clinically-relevant 4T1 mouse breast cancer model. BMC Cancer, 2014, 14:329. (IF：3.362)\r
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Mingji Jin, Wei Chen, Wei Huang, Long Rong, Zhonggao Gao*. Preparation of pegylated lumbrokinase and an evaluation of its thrombolytic activity both in vitro and in vivo. Acta Pharmaceutica Sinica B, 2013, 3(2):123-129.\r
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Yunfei Li, Feifei Yang, Wei Chen, Jiaoyang Liu, Wei Huang, Mingji Jin, and Zhonggao Gao*. A Novel Monomethoxy Polyethylene Glycol-Polylactic Acid Polymeric Micelles with Higher Loading Capacity for Docetaxel and Well-Reconstitution Characteristics and Its Anti-metastasis Study. Chem Pharm Bull, 2012, 60(9):1146-1154.\r
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Wei Huang, Ming Lv, Zhong Gao Gao*. Synthesis of polyethylenimine grafted with copolymers of polyethylene glycol and polycaprolactone and its potential for siRNA delivery. Chinese Chemical Letters, 2011, 22(6):749-752.\r
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Zhong Gao Gao, Li Tian, Jun Hu, In Suh Park, You Han Bae. Prevention of Metastasis in a 4T1 Murine Breast Cancer Model by Doxorubicin Carried by Folate Conjugated pH Sensitive Polymeric Micelles. Journal of Controlled Release, 2011, 152: 84-89.\r
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Natalya Rapoport, Kweon-Ho Nam, Roohi Gupta, Zhonggao Gao, Praveena Mohan, Allison Payne, Nick Todd , Xin Liu , Taeho Kim, Jill Shea, Courtney Scaife, Dennis L. Parker, Eun-Kee Jeong, Anne M. Kennedy. Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions. Journal of Controlled Release, 2011,153 (1):4-15.\r
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D. Kim, Z.G. Gao, E.S. Lee, Y.H. Bae. In vivo evaluation of doxorubicin-loaded polymeric micelles targeting folate receptors and early endosomal pH in drug-resistant ovarian cancer. Molecular Pharmaceutics. 2009, 6(5):1353-1362.