个人简历

2008年获德国马丁-路德大学博士学位。2008年-2010年，在德国弗莱堡大学医学院进行博士后研究; 2010年-2017年历任弗莱堡大学医学院助理研究员/课题组长及研究员(PI)。2017年3月起，任中国医学科学院/北京协和医学院“协和学者”教授，任职于病原生物学系。

研究领域

研究方向为膜蛋白的生成与演化以及蛋白质的跨膜转运机理，具体为革兰氏阴性菌外膜β-桶状蛋白的膜整合与演化和病原蛋白跨细菌外膜的转运机理研究；以外膜蛋白为靶点的新型抗生素开发(包括天然产物的分离分析及基于此的药物筛选)；基于蛋白质跨细菌外膜转运的细菌细胞表面蛋白展示技术为基础的生物工程产品开发（如疫苗开发等）。

近期论文

1，Chuanyi Yao*, Jinliang Chen, Yinghua Lu, Shaokun Tang, Enguo Fan*. Construction of an asynchronous three-zone simulated-moving-bed chromatography and its application for the separation of vanillin and syringaldehyde, Chemical Engineering Journal，2018, 331:644-651.
2，Shanshan Tian, Shuzhen Zheng, Yanpu Han, Zhenchang Guo, Guijin Zhai, Xue Bai, Xi-Wen He, Enguo Fan, YuKui Zhang, and Kai Zhang. Maleic Anhydride Labeling-based Approach for Quantitative Proteomics and Successive Derivatization of Peptides. Analytical Chemistry, 2017, 89(16):8259-8265.
3, Wenjing Bi, Xue Bai, Fan Gao, Congcong Lu, Ye Wang, Guijin Zhai, Shanshan Tian, Enguo Fan. Yukui Zhang, and Kai Zhang, DNA-Templated Aptamer Probe for Identification of Target Proteins. Analytical Chemistry, 2017, 89(7):4071-4076.
4, Chuanyi Yao*, Kaili Yue, Xueping Ling, Keju Jing, Yinghua Lu, Shaokun Tang and Enguo Fan*. Biocatalytic synthesis of vitamin A palmitate using immobilized lipase produced by recombinant Pichia pastoris, Engineering in Life Sciences, 2017, 17: 768-774.
5, Chengchao Ding, Enguo Fan, Shujuan Wang, Liang Guo, Jie Li, Qing Liu. A potential aquaculture vaccine vector: Evaluation of a double-gene attenuated Listeria monocytogenes in zebrafish ( Danio rerio ), Aquaculture, 2017, 479: 311-320.
6, Dongmei Xi, Jizhen Shang, Enguo Fan, Jinmao You, Shusheng Zhang, and Hua Wang, Nanopore-Based Selective Discrimination of MicroRNAs with Single-Nucleotide Difference Using Locked Nucleic Acid-Modified Probes, Analytical Chemistry, 2016, 88(21): 10540-10546.
7, Xue Bai, Congcong Lu, Jin Jin, Shanshan Tian, Zhenchang Guo, Pu Chen, Guijin Zhai, Shuzhen Zheng, Xiwen He, Enguo Fan, Yukui Zhang, and Kai Zhang. Development of DNA-templated Peptide Probe for Photo-affinity Labeling and Enrichment of the 'Readers' of Histone Modification，Angewandte Chemie International Edition, 2016, 55(28): 7993-7997.
8, Haijuan Zeng, Wenbo Guo, Beibei Liang, Jianwu Li, Xuzhao Zhai, Chunmei Song, Wenjun Zhao*, Enguo Fan*, Qing Liu*, Self-Paired Monoclonal Antibody Lateral Flow Immunoassay Strip for Rapid Detection of Acidovorax avenae subsp. Citrulli, Analytical and Bioanalytical Chemistry, 2016, 408:6071–6078.
9, Enguo Fan, Nandini Chauhan, Gupta Udatha, Jack Leo, Dirk Linke. Type V secretion systems in bacteria, Microbiology Spectrum, 2016, 3(6): VMBF-0009-2015. in Virulence Mechanisms of Bacterial Pathogens, Fifth Edition, ASM press (Book chapter).
10, Enguo Fan, Derrick Norell, Matthias Müller. An In Vitro Assay for Substrate Translocation by FhaC in Liposomes. Methods in Molecular Biology, 2015, 1329:111-125.
11, Luisa Estrada Mallarino, Enguo Fan, Meike Odermatt, Matthias Müller, Jie Liang, MeiShan Lin, Martin Heinzelmann, Fenja Fritsche, Hans-Jürgen Apell, Wolfram Welte. TtOmp85, a β-Barrel Assembly Protein, Functions by Barrel Augmentation. Biochemistry, 2015, 54 (3): 844–852.
12, Yanfang Wu, Xinsheng Wang, Enguo Fan*, Extraction, Structure, and Bioactivities of the Polysaccharides from Fructus. Book chapter in Polysaccharides: Bioactivity and Biotechnology (Edited by Jean-Michel Merillon and Kishan G. Ramawat), Springer Verlag, Germany, 2015, 1585-1607 (Book chapter).
13, Man Wu, Haolin Li, Yinghui Jiang, Chunmei Song, Huiqin Guo, Shuyan Wu, Cheng Liu, Jianwu Li, Haijuan Zeng, Xuzhao Zhai, Weisheng Zhang,* Enguo Fan* and Qing Liu*. Simultaneous quantification of Escherichia coli O157:H7 and Shigella boydii using a visual-antibody-macroarray. Analyst, 2015, 140(19):6595-601.
14, Ye Wang, Yanpu Han, Enguo Fan*, Kai Zhang*. Analytical strategies used to identify the readers of histone modifications: A review. Analytica Chimica Acta, 2015, 891:32-42.
15, Yanpu Han, Congcong Lu, Kai Zhang, Shanshan Tian, Enguo Fan, Langxing Chen, Xi-Wen He and Yukui Zhang. Quantitative characterization of histones post-translational modifications using stable isotope dimethyl-labeling strategy. Analytical Methods, 2015, 7: 3779-3785.
16, Derrick Norell, Alexander Heuck, Thuy-Anh Tran-Thi, Hansjörg Götzke, Françoise Jacob-Dubuisson, Tim Clausen, Daniel O. Daley, Volkmar Braun, Matthias Müller*, Enguo Fan*, Versatile in vitro system to study translocation and functional integration of bacterial outer membrane proteins. Nature Communications, 2014, 5:5396.
17, Kai Zhang, Liyan Li, Mengxiao Zhu, Guojuan Wang, Jianjun Xie, Yunlong Zhao, Enguo Fan, Liyan Xu, Enmin Li, Comparative analysis of histone H3 and H4 post-translational modifications of esophageal squamous cell carcinoma with different invasive capabilities. Journal of Proteomics, 2014, 2014, 112C:180-189.
18, Qiang Wang, Xin Zhao, Yanrong Ren, Enguo Fan, Haijun Chang, Hongbin Wu, Effects of high pressure treatment and temperature on lipid oxidation and fatty acid composition of yak (Poephagus grunniens) body fat. Meat Science. 2013, 94(4):489-494.
19, Changzhen Wang, Hongmei Zhou, Ruiyun Peng, Lifeng Wang, Zhentao Su, Peng Chen, Shuiming Wang, Shaoxia Wang, Yao Liu, Jianbo Cong, Ke Wu*, Xiangjun Hu*, Enguo Fan*, Electromagnetic Pulse Reduces Free Radical Generation in Rat Liver Mitochondria In Vitro, Free Radical Research 2013, 47(4): 276-82.
20, Kai Zhang*, Shanshan Tian, Enguo Fan*, Protein lysine acetylation analysis: current MS-based proteomic technologies. Analyst. 2013, 138 (6), 1628-1636.