个人简历

张灿：女，1965年5月生。教授，药物化学与药物制剂学博士研究生导师，药物科学研究院院长，高端药物制剂与材料研究中心主任。
1986.7-至今中国药科大学工作。2001.1-2003.12 南京大学化学化工学院高分子化学和物理专业博士；1996.9-2000.7 中国药科大学药物化学专业硕士；1982.9-1986.7 南京大学化学系高分子合成材料专业学士。曾任美国马里兰大学访问教授和日本富山医药科大学高级访问学者。享受国务院政府特殊津贴。兼入选教育部新世纪创新人才、江苏省“333高层次人才培养工程”科技带头人、江苏省“333高层次人才培养工程”第二层次培养对象、江苏省青蓝工程优秀青年骨干教师。获教育部自然科学一等奖、江苏省科技进步三等奖、江苏省青年科学家奖提名奖等奖项。连续6年（2013-2018）被评为ESI中国高被引学者。
作为课题负责人主持科技部新药创制重大专项、新药创制重大专项关键技术子课题，科技部国际交流重点项目、863计划、国家自然科学基金重点和面上项目、教育部重点项目等40余项科研项目。作为通讯作者，在Nature Nanotechnology 、Journal of The American Chemical Society、Angewandte Chemie International Edition（VIP, cover story）、Advanced Materials（cover story）、Nano Letters、Biomaterials、Journal of Controlled Release和Journal of Medicinal Chemistry等刊物共发表SCI收录论文100余篇，最高影响因子38.986。获得授权发明专利21项。主译著作1部，参编著作3部。指导的研究生与本科生分别获得江苏省优秀博士论文（3人次）、江苏省优秀硕士论文（1人次）与江苏省优秀本科论文（1人次）。

研究领域

""主要围绕新型药用材料与递药系统（药剂学）和新药发现（药物化学）两个学科领域。重点聚焦以下方向：
（1）药用功能脂质分子及基因药物递送系统
（2）药物载体的模块化组装
（3）细胞工程化及活细胞药物
（4）基于维生素D受体激动剂等免疫调节性新药发现""""

近期论文

Chunming Tang, Cong Wang, Ying Zhang, Lingjing Xue, Yanyi Li , Caoyun Ju*, Can Zhang*. Recognition, Intervention, and Monitoring of Neutrophils in Acute Ischemic Stroke. Nano Letters, 2019,19(7), 4470-4477. (IF 12.279)\r
\r
L Zhang#, Y Zhang#, YN Xue,Y Wu, QQ Wang, LJ Xue, ZG Su*, C Zhang*. Transforming Weakness into Strength Photothermal-Therapy-Induced Inflammation Enhanced Cytopharmaceutical Chemotherapy as a Combination Anticancer Treatment. Advanced Materials, 2019, 31(5), 1805936. (IF 21.950)\r
\r
CY Ju#, Yj Wen#, LP Zhang, QQ Wang, LJ Xue, J Shen, C Zhang*. Neoadjuvant Chemotherapy Based on Abraxane/Human Neutrophils Cytopharmaceuticals with Radiotherapy for Gastric Cancer. Small, 2019, 15(5), 1804191. (IF 9.598)\r
\r
MX Hao, SY Hou, LJ Xue, HL Yuan, LL Zhu, C Wang, B Wang, CM Tang, C Zhang*. Further Developments of the Phenyl-Pyrrolyl Pentane Series of Nonsteroidal Vitamin D Receptor Modulators as Anticancer Agents. J Med Chem. 2018, 61: 3059-75. （IF 6.253）\r
\r
ZS Kang#, C Wang#, XL Han, JJ Du, YY Li, C Zhang*. Design, synthesis and biological evaluation of non-secosteriodal vitamin D receptor ligand bearing double side chain for the treatment of chronic pancreatitis. European Journal of Medicinal Chemistry, 2018, 146: 541-553. (IF: 4.816) \r
\r
C Wang#, B Wang#, LJ Xue, ZS Kang, SY Hou, JJ Du, C Zhang*. Design, Synthesis and Antifibrosis Activity in Liver of Nonsecosteroidal Vitamin D Receptor Agonists with Phenyl-pyrrolyl Pentane Skeleton. Journal of Medicinal Chemistry, 2018. DOI: 10.1021/acs.jmedchem.8b01165. (IF: 6.253)\r
\r
ZK Zhao, Y Zhang, CL Tian, TJ Yin*, C Zhang*. Facile dynamic one-step modular assembly based on boronic acid-diol for construction of a micellar drug delivery system. Biomaterial Sciences, 2018, 6(10): 2605-2618. (IF: 5.831)\r
\r
Q Sun, CM Tang, ZG Su, JJ Du, YK Shang, LJ Xue, C Zhang*. A modular assembly pH-sensitive charge reversal siRNA delivery system. Biomaterials Science, DOI: 10.1039/c8bm01062e. (IF: 5.831)\r
\r
ZS Kang#, C Wang#, XL Han, B Wang, HL Yuan, SY Hou, MX Hao, JJ Du, YY Li, AW Zhou, C Zhang*. Sulfonyl-containing phenyl-pyrrolyl pentane analogues: Novel non-secosteroidal vitamin D receptor modulators with favorable physicochemical properties, pharmacokinetic properties and anti-tumor activity. European Journal of Medicinal Chemistry, 2018, 157: 1174-1191. (IF: 4.816) \r
\r
JW Xue, ZK Zhao, L Zhang, LJ Xue, SY Shen, YJ Wen, ZY Wei, L Wang, LY Kong, HB Sun, QN Ping, R Mo*, C Zhang*. Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence. Nature Nanotechnology, 2017, 12(7): 692-700. (IF 38.986)\r
\r
X Feng, W Yu, X Li, F Zhou, W Zhang, Q Shen, J Li, C Zhang*, P Shen*. Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. Biochemical Pharmacology, 2017, 136:136-149. (IF 4.75)\r
\r
T Cui, JJ Liang, H Chen, DD Geng, L Jiao, JY Yang, H Qian, C Zhang*, Y Ding*. Performance of Doxorubicin-Conjugated Gold Nanoparticles: Regulation of Drug Location. ACS Applied Materials & Interfaces, 2017, 9(10): 8569-8580. (IF: 7.504)\r
\r
B Wang, MX Hao, C Zhang*. Design, synthesis and biological evaluation of nonsecosteroidal vitamin D3 receptor ligands as anti-tumor agents. Bioorganic & Medicinal Chemistry Letters, 2017, 27: 1428-1436. (IF: 2.454)\r
\r
XY Chen, YD Zhang, CM Tang, CL Tian, Q Sun, ZG Su, LJ Xue, YF Yin, CY Ju*, C Zhang*. Co-delivery of paclitaxel and anti-survivin siRNA via redox-sensitive oligopeptide liposomes for the synergistic treatment of breast cancer and metastasis. International Journal of Pharmaceutics, 2017, 529(1-2): 102-115. (IF: 3.649)\r
\r
YJ He, ZG Su, LJ Xue, H Xu*, C Zhang*. Co-delivery of erlotinib and doxorubicin by pH-sensitive charge conversion nanocarrier for synergistic therapy. J Control Release.2016. 229: 80-92. (IF: 7.705)\r
\r
N Zhang, XF Xu, X Zhang, D Qu, LJ Xue*, R Mo, C Zhang*. Nanocomposite hydrogel incorporating gold nanorods and paclitaxel-loaded chitosan micelles for combination photothermal-chemotherapy. Int J Pharm. 2016, 497(1-2): 210-221. (IF: 3.65)\r
\r
ZX Ge, MX Hao, M Xu, ZG Su, ZS Kang, LJ Xue**, C Zhang*. Novel nonsecosteroidal VDR ligands with phenyl-pyrrolyl pentane skeleton for cancer therapy. Eur J Med Chem. 2016, 107: 48-62. (IF: 3.447)\r
\r
DB Yang, TF Wang, ZG Su*, LJ Xue, R Mo, C Zhang*. Reversing Cancer Multidrug Resistance in Xenograft Models via Orchestrating Multiple Actions of Functional Mesoporous Silica Nanoparticles. ACS Applied Materials & Interfaces 2016, 8 (34): 22431-22441. (IF: 7.504)\r
\r
SY Yin, CM Tang, B Wang, Y Zhang, LL Zhou, LJ Xue*, C Zhang*. Design, synthesis and biological evaluation of novel EGFR/HER2 dual inhibitors bearing a oxazolo[4,5-g]quinazolin-2(1H)-one scaffold. European Journal of Medicinal Chemistry 2016, 120: 26-36. (IF: 3.902)\r
\r
TF Wang, XF Liu, MX Hao, JN Qiao, CY Ju, LJ Xue*, C Zhang*. Design, synthesis and evaluation of pyrrolo[2,3-d]pyrimidine-phenylamide hybrids as potent Janus kinase 2 inhibitors. Bioorganic & Medicinal Chemistry Letters 2016, 26(12): 2936-2941. (IF: 2.486)\r

兼任英国皇家化学会期刊Biomaterials Science副主编、中国复合材料学会生物医用复合材料分会常务委员、中国药学会纳米药物专业委员会委员、天津市临床药物关键技术重点实验室学术委员会委员、中国药科大学学报编委和中国药科大学学术委员会委员。