个人简历

赵丽，教授，博士生导师。曾获学校教学成果三等奖2项。参编研究生教材《肿瘤药理学》，本科生教材《人体解剖生理学》，参编科研论著《恶性肿瘤多药耐药的逆转》， 获得授权发明专利多项。曾获得江苏省高校“青蓝工程”中青年学术带头人称号。“上海复星医药奖教学金” 优秀青年教师。2014-2015年在美国佛罗里达大学访学。发表SCI论文20余篇，累计影响因子100，总引用次数500余次。

研究领域

从事肿瘤发病机制及天然抗肿瘤药物的药效学和作用机制研究，主攻肿瘤微环境介导肿瘤耐药的机制研究和相关药物开发

近期论文

Qinglong Guo#, Lu Lu#, Yan Liao, Xiaoping Wang, Yi Zhang, Yicheng Liu, Shaoliang Huang, Haopeng Sun, Zhiyu Li, Li Zhao*，Influence of c-Src on Hypoxic Resistance to Paclitaxel in Human Ovarian Cancer Cells and Reversal of FV-429., Cell Death & Disease, 2018 Jan 11;8(1):e3178. (IF 5.965）
Xiaobo Zhang, Yicheng Liu, Lu Lu, Shaoliang Huang, Youxiang Ding, Yi Zhang, Qinglong Guo, Zhiyu Li* and Li Zhao*，Oroxyloside A overcomes bone marrow microenvironment-mediated chronic myelogenous leukemia resistance to imatinib via suppressing hedgehog pathway，Frontiers in Pharmacology, 2017 Aug 11;8:526.., (IF 4.400）
Zhang X#,Kang Y#,Huo T,Tao R,Wang X,Li Z,Guo Q*,Zhao L*, GL-V9 induced upregulation and mitochondrial localization of NAG-1 associates with ROS generation and cell death in hepatocellular carcinoma cells.,Free Radic Biol Med.2017 Jul 9;112:49-59. (IF 5.606）
Wenjun Li#, Qilong Ding#, Youxiang Ding, Lu Lu, Xiaoping Wang, Yi Zhang ,Xiaobo Zhang, Qinglong Guo*, Li Zhao*., Oroxylin A Reverses the Drug Resistance of Chronic Myelogenous Leukemia cells to Imatinib through CXCL12/CXCR7 axis in Bone Marrow Microenvironment，Molecular Carcinogenesis,2017 Mar;56(3):863-876（IF 4.185)
Ying Ge#, Aibo Li#, Jianwei Wu, Haiwei Feng, Letian Wang, Hongwu Liu, Yungen Xu, Qingxiang Xu*, Li Zhao*, Yuyan Li*. Design, synthesis and biological evaluation of novel non-peptide boronic acid derivatives as proteasome inhibitors, Eur J Med Chem. 2017 Jan 23;128:180-191.（IF 4.519)
Yi Zhang#, Xuefen Xu#, Wei Li, Hanchi Miao, Shaoliang Huang, Yuxin Zhou, Yang Sun, Zhiyu Li, Qinglong Guo*, Li Zhao*, Activation of endoplasmic reticulum stress and the extrinsic apoptotic pathway in human lung cancer cells by the new synthetic flavonoid, LZ-205 , oncotarget, 2016 Dec 27;7(52):87257-87270.（IF 5.168)
Raoling Ge, Qian Zhao, Zhouling Xie, Lu Lu, Qinglong Guo, Zhiyu Li* , Li Zhao*，Synthesis and Biological Evaluation of 6-fluoro-3-phenyl-7-piperazinyl Quinolone Derivatives as Potential Topoisomerase I Inhibitors, European Journal of Medicinal Chemistry, Volume 122, 21 October 2016, Pages 465–474（IF 4.519)
Xiaoping Wang#, Yang Sun#, Yue Zhao, Youxiang Ding, Xiaobo Zhang, Lingyi Kong , Zhiyu Li, Qinglong Guo*, Li Zhao*., Oroxyloside prevents dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB pathway through PPARγ activation., Biochemical Pharmacology, Volume 106, 15 April 2016, 70-81（IF4.581)
Li Zhao#, Han-Chi Miao#, Wen-Jun Li, Yang Sun, Zhi-Yu Li, Qing-Long Guo*，LW-213 induces G2/M cell cycle arrest through Akt/Gsk3β/β-catenin signaling pathway in human breast cancer cells，Molecular carcinogenesis，2016 May;55(5):778-92（IF4.185）
Xin Li，Han-chi Miao，Yi Zhang，Wei Li，Zhiyu Li，Yu-xin Zhou，Li Zhao*，Qing-Long Guo*，Bone marrow microenvironment confers imatinib resistance to chronic myelogenous leukemia and oroxylin A reverses the resistance by suppressing Stat3 pathway.，Archives of Toxicology, 89(1), January, 2015, 121-136（IF6.637）