个人简历

2010年毕业于青岛大学医学院药学专业；2015年毕业于中国药科大学，获药物化学专业博士学位，同年留校任教；2018年任副研究员。现任职于中国药科大学药物代谢动力学重点实验室。目前主要基于核苷类药物及天然活性分子的药代动力学特征，开展创新药物分子的设计、合成及生物活性研究。

研究领域

基于药代动力学的创新药物分子发现

近期论文

Zhen Le, Dai Liang, Wen Xiaoan, Yao Lan, Jin Xiaoliang, Yang Xiao-Wen, Zhao Wenfeng, Yu Sheng-Qi, Yuan Haoliang, Wang Guangji, Sun Hongbin, Discovery of Novel Nucleotide Prodrugs with Improved Potency Against HCV Variants Carrying NS5B S282T Mutation,Journal of Medicinal Chemistry, 2017, 60, 6077-6088.
Zhen Le, Wang Jiankun, Xu Qing-Long, Sun Hongbin, Wen Xiaoan, Wang Guangji, Direct Intermolecular C–H Functionalization Triggered by 1, 5-Hydride Shift: Access to N-Arylprolinamides via Ugi-Type Reaction,Organic Letters, 2017, 19, 1566-1569.
Lin Chao,Zhen Le (coauther), Cheng Yong, Du Hong-Jin, Zhao Hui, Wen Xiaoan, Kong Ling-Yi, Xu Qing-Long, Sun Hongbin, Visible-Light Induced Isoindoles Formation To Trigger Intermolecular Diels–Alder Reactions in the Presence of Air,Organic Letters, 2015, 17, 2684-2687.
Wang Jiankun, Sun Yilin, Wang Guangji,Zhen Le*, DEAD-Promoted Oxidative Ugi-Type Reaction Including an Unprecedented Ugi Amidation Assisted by Dicarboxylic Acids,European Journal of Organic Chemistry, 2017, 6338-6348.
Zhen Le, Dai Liang, Yu Sheng-Qi, Lin Chao, Sun Hongbin, Xu Qing-Long, Reaction Pathways through a [1, 5]-Hydride Shift Triggered by Acids: Approach to Bridged-Ring Heterocycles and Polycycles,European Journal of Organic Chemistry, 2017, 560-569.