张惠斌
近期热点
资料介绍
个人简历
张惠斌,女,1964年12月出生。1984年本科毕业于南京药学院制药化学专业,1989年和2004年在中国药科大学分别获得药物化学硕士和博士学位。1989年起在中国药科大学新药研究中心长期从事新药研究和开发工作。负责国家自然科学基金、国家重大新药创制专项、江苏省产学研联合创新项目等。负责完成3项江苏省自然科学基金项目课题。负责完成多名硕士和博士研究生的论文指导工作。是国家自然科学基金和保健品评审专家。负责申请专利20多项,获得授权专利9项,发表论文90余篇。研究领域
抗代谢性疾病药物研究,主要针对代谢性疾病及肿瘤新靶点的创新药物研究近期论文
1. Junhao Xing, Lingyun Yang, Yifei Yang, Leilei Zhao, Qiangqiang Wei, Jian Zhang,Jinpei Zhou, Huibin Zhang*. Design, synthesis and biological evaluation of novel 2,3-dihydroquinazolin-4(1H)-one derivatives as potential fXa inhibitors. European Journal of Medicinal Chemistry, 2017,125,411-422.2. Leilei Zhao, Yifei Yang, Yahui Guo, Lingyun Yang, Jian Zhang, Jinpei Zhou*, Huibin Zhang*. Design, synthesis and biological evaluation of 7-methylimidazo [1,5-a]pyrazin-8 (7H)-one derivatives as BRD4 inhibitors. Bioorganic & Medicinal Chemistry, 2017, 25(8), 2482-2490.3. Lingyun Yang, Li Han, Bin Xu, Leilei Zhao, Jinpei Zhou, and Huibin Zhang*. Palladium-Catalyzed C−HBondOrthoAcylation/AnnulationwithTolueneDerivatives Toluene Derivatives.Asian Journal of Organic Chemistry, 2016, 5 (1): 62-65 .4. Xing J, Yang L, Li H, Li Q, Zhao L, Wang X, Zhang Y, Zhou M, Zhou J, Zhang H*. Identification of anthranilamide derivatives as potential factor Xa inhibitors: drug design, synthesis and biological evaluation. Eur J Med Chem, 2015 5; 95: 388-99 5. Li Q, Zhou M, Han L, Cao Q, Wang X, Zhao L, Zhou J, Zhang H*. Design, Synthesis and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel DPP-4 Inhibitors. Chem Biol Drug Des, 2015, 86(4): 849-56 6. Xing J, Li Q, Zhang S, Liu H, Zhao L, Cheng H, Zhang Y, Zhou J, Zhang H*. Identification of Dipeptidyl Peptidase IV Inhibitors: Virtual Screening, Synthesis and Biological Evaluation. Chem Biol Drug Des. 2014 , 84(3):364-77.7. Li Q, Hu Q, Wang X, Zong Y, Zhao L, Xing J, Zhou J, Zhang H*. Discovery of Novel 2-(piperidin-4-yl)-1H-benzo[d]imidazole Derivatives as Potential Anti-Inflammatory Agents. Chem Biol Drug Des. 2015, 86(4):509-16.8. Huibin Zhang, Yaan Zhang, Guanzhong Wu, Jinpei Zhou, Wenlong Huang, Xiaowen Hu, Synthesis and biological evaluation of sulfonylurea and thiourea derivatives substituted with benzenesulfonamide groups as potential hypoglycemic agents , Bioorganic & Medicinal Chemistry Letters, 2009, 19(6), 1740-17449. Jing Li, Huibin Zhang,*, Wenlong Huang, Hai Qian and Ying Li. TNF-Inhibitors with Anti-Oxidative Stress Activity from Natural Products. Current Topics in Medicinal Chemistry, 2012, 12, 1408-142110. Huibin Zhang, Yaan Zhang, Guanzhong Wu, Jinpei Zhou, Wenlong Huang, Xiaowen Hu, Synthesis and biological evaluation of sulfonylurea and thiourea derivatives substituted with benzenesulfonamide groups as potential hypoglycemic agents , Bioorganic & Medicinal Chemistry Letters, 2009, 19(6), 1740-174411. Yubin Wang, Hai Qian, Jinpei Zhou, Huibin Zhang*, and Jianfeng Ji and Wenlong Huang. Synthesis and Bioactivities of 2-Azetidinone Derivatives as Cholesterol Absorption Inhibitors. Medicinal Chemistry, 2011, 7, 534-54212. Wenyuan Liu, Ainan Zhoua, Feng Feng, Huibin Zhang*, Jinpei Zhou, Wenlong Huang. Qualitative and quantitative studies on impurities in G004, a potential hypoglycaemic agent, using liquid chromatography, nuclear magnetic resonance and mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 2011, 56, 627-632 13. Hui Bin Zhang, Yu Shi Chi, Wen Long Huang, Shuai Jian Ni. Total synthesis of human urotension-II by microwave-assisted solid phase method. Chinese Chemical Letters, 2007, 18 : 902–904. 14. Yushi Chi, Huibin Zhang*, Wenlong Huang, Jinpei Zhou, Yinghong Zhou, Hai Qian, Shuaijian Ni. Microwave-assisted solid phase synthesis, PEGylation, and biological activity studies of glucagon-like peptide-1(7–36) amide,Bioorganic & Medicinal Chemistry, 2008, 16 (16),7607-761415. Chi, Yushi; Zhang, Huibin*; Zhou, Jinpei; Huang, Wenlong; Ni, Shuaijian, Microwave-Assisted Solid Phase Synthesis of GLP-1-Analogues, Letters in Organic Chemistry, 2008 5(5),399-402(4) 16. Yu Li, Hui-bin Zhang*, Wen-long Huang, Yun-man Li ,Design and synthesis of tetrahydroisoquinoline derivatives as potential multidrug resistance reversal agents in cancer,Bioorganic & Medicinal Chemistry Letters, 2008, 18(12),3652-365517. Jing Li, Wenlong Huang, Huibin Zhang*, Xinyang Wang, Huiping Zhou. Synthesis of andrographolide derivatives and their TNF-α and IL-6 expression inhibitory activities,Bioorganic & Medicinal Chemistry Letters, 2007,17(24) , 6891-689 相关热点
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