个人简历

叶慧，女，现任中国药科大学副研究员、博士生及硕士生导师。2008年于四川大学获得本科学士学位，2013年获得美国威斯康星大学麦迪逊分校药学院博士学位。获得江苏省六大人才高峰、江苏省科协青年人才托举工程、江苏省双创博士的资助，主持国自然面上项目、青年项目、江苏省优秀青年项目、国家科技重点专项子任务、江苏省自然青年项目、教育部留学回国人员资助项目等科研项目，参与多项重大新药创制专项及重点研发计划。
迄今在生物和分析化学权威期刊Redox Biol、Anal Chem、Mol Cell Proteomics、Anal Chim Acta、Cell Death Dis等以一作/通讯共发表SCI文章近30篇。申请人曾参加 ASMS、Neuroscience、PittCon、BCEIA等多个国际学术会议作特邀及展板报告，并受邀成为Anal Chem、Anal Chim Acta、J Chromatogr A等SCI期刊的审稿人。

研究领域

（1）建立国际领先的代谢-蛋白多组学前沿技术，发现细胞内活性分子与靶蛋白的未知相互作用关系，聚焦肿瘤代谢，阐明疾病状态下紊乱的内源性代谢物对结合蛋白的功能调控模式，发现抗肿瘤的原创代谢靶标；
（2）基于化学蛋白质组学与分子生物学手段，阐明临床具有确切疗效的天然药物水飞蓟宾等对机体的代谢调控机制，优化结构，开发出针对功能靶标的新分子。
（3）基于长期在多肽及蛋白领域的丰富研究经验，开展生物药物的细胞药代动力学研究，精确描述生物药在靶细胞内的活性形式及代谢过程，指导创新生物药物的改造、筛选及评价。""

近期论文

Chang Shao, Wenjie Lu, Ye Du, Wenchao Yan, Qiuyu Bao, Yang Tian, Guangji Wang, Hui Ye*, Haiping Hao*. Cytosolic ME1 integrated with mitochondrial IDH2 supports tumor growth and metastasis, Redox Biol, in revision. IF=9.984.
Gaoyuan Lu, Xiaowei Xu, Gongyu Li, Huiyong Sun, Nian Wang, Yinxue Zhu, Ning Wan, Yatao Shi, Guangji Wang, Lingjun Li, Haiping Hao*, Hui Ye*. Subresidue-Resolution Footprinting of Ligand–Protein Interactions by Carbene Chemistry and Ion Mobility–Mass Spectrometry, Anal Chem. 2020, 92(1):947-956. IF=6.785.
Guoxiu Cao, Nian Wang, Dandan He, Xinmiao Wang, Yang Tian, Ning Wan, Wenchao Yan, Hui Ye*, Haiping Hao*, Intestinal mucosal metabolites-guided detection of trace-level ginkgo biloba extract metabolome, J Chromatogr A. 2019, 1608:460417.
Runbin Sun, Jingqiu Huang, Na Yang, Jun He, Xiaoyi Yu, Siqi Feng, Yuan Xie, Guangji Wang, Hui Ye*, Jiye Aa*, Purine Catabolism Shows a Dampened Circadian Rhythmicity in a High-fat Diet-Induced Mouse Model of Obesity, Molecules. 2019, 24(24):4524.
Chang shao, Wenjie Lu, Ning Wan, Mengqiu Wu, Qiuyu Bao, Yang Tian, Gaoyuan Lu, Nian Wang, Haiping Hao*, Hui Ye*. Integrative Omics Analysis Revealed that Metabolic Intervention Combined with Metronomic Chemotherapy Selectively Kills Cancer Cells. J Proteome Res. 2019,18, 6:2643-2653
Qiuling Zheng, Xujun Ruan, Yang Tian, Jiaojiao Hu, Ning Wan, G Lu, Xunxun Wu, Guangji Wang, Haiping Hao*, Hui Ye*. Ligand-protein target screening from cell matrices using reactive desorption electrospray ionization-mass spectrometry via a native-denatured exchange approach.Analyst. 2019 Jan 14;144(2):512-520.
Jialing Han, Chengyu Chu, Guoxiu Cao, Wuxiang Mao, Sen Wang, Zhou Zhao, M Gao, Hui Ye*, Xiaowei Xu*.A simple boronic acid-based fluorescent probe for selective detection of hydrogen peroxide in solutions and living cells. Bioorg Chem.2018 Dec;81:362-366.
Qiuling Zheng‡, Yang Tian‡, Xujun Ruan, Hao Chen, Xunxun Wu, Xiaowei Xu, Guangji Wang, Haiping Hao*, Hui Ye*. Probing specific ligand-protein interactions by native-denatured exchange mass spectrometry.Anal Chim Acta. 2018 Dec 7;1036:58-65. IF=5.256.
Qingran Li‡, Lijuan Cao‡, Yang Tian, Pei Zhang, Chujie Ding, Wenjie Lu, Chenxi Jia, Chang Shao, Wenyue Liu, Dong Wang, Hui Ye*, Haiping Hao*. Butyrate Suppresses the Proliferation of Colorectal Cancer Cells via Targeting Pyruvate Kinase M2 and Metabolic Reprogramming.Mol Cell Proteomics. 2018 May 8. pii: mcp.RA118.000752.
Hui Ye‡, Jingxin Wang‡, Zichuan Tian, James Dowell, Quentin Bremer, Gaoyuan Lu, Brian Baldo*, Lingjun Li*. Quantitative Mass Spectrometry Reveals Food Intake-Induced Neuropeptide Level Changes in Rat Brain: Functional Assessment of Selected Neuropeptides as Feeding Regulators. Mol Cell Proteomics. 2017 Nov; 16(11):1922-1937 (Cover article). IF 5.236.
Mengqiu Wu‡, Hui Ye‡, Zhiyuan Tang‡, Chang Shao, Gaoyuan Lu, Baoqiang Chen, Yuyu Yang, Guangji Wang*, Haiping Hao*. p53 dynamics orchestrates with binding affinity to target genes for cell fate decision. Cell Death Dis. 2017 Oct 19;8(10):e3130. IF=5.638
Lin Wang ‡，Hui Ye ‡，Di Sun，Tuo Meng，Lijuan Cao，Mengqiu Wu，Min Zhao，Yun Wang，Baoqiang Chen，Xiaowei Xu，Guangji Wang *，Haiping Hao*. A metabolic pathway extension approach for metabolomic biomarker identification.，Anal Chem，2017, 89(2):1229-1237. IF 6.042
Hua Sang，Gaoyuan Lu，Yazhong Liu，Qiyue Hu，Weifeng Xing，Dongbing Cui，Fang Zhou，Jingwei Zhang，Haiping Hao，Guangji Wang*，Hui Ye*. Conjugation site analysis of antibody-drug-conjugates (ADCs) by signature ion fingerprinting and normalized area quantitation approach using nano-liquid chromatography coupled to high resolution mass spectrometry. Anal Chim Acta，2017 Feb 22，22(955):67~78. IF=5.123
Mengqiu Wu ‡, Hui Ye ‡, Chang Shao, Xiao Zheng, Qingran Li, Lin Wang, Min Zhao, Gaoyuan Lu, Baoqiang Chen, Jun Zhang, Yun Wang, Guangji Wang*, Haiping Hao**. Metabolomics-proteomics combined approach identifies differential metabolism-associated molecular events between senescence and apoptosis. J Proteome Res. 2017 May 10.
Ye H‡, Wang L‡, Zhu L, Sun D, Luo X, Wang H, Wang G, Hao H. Stepped collisional energy MSAll: an analytical approach for optimal MS/MS acquisition of complex mixture with diverse physicochemical properties. J Mass Spectrom, 2016, 51(5):328-41.
Ye H‡, Zhu L‡, Wang L, Liu H, Zhang J, Wu M, Wang G*, Hao H*. Stepped MSAll Relied Transition (SMART): an approach to rapidly determine optimal multiple reaction monitoring mass spectrometry parameters for small molecules. Anal Chim Acta. 2016, 51(5):328-41.
Ye H, Wang J, Zhang Z, Jia C, Schmerberg C, Catherman AD, Thomas PM, Kelleher NL, Li L*. Defining the Neuropeptidome of the Spiny Lobster Panulirus interruptus Brain Using a Multidimensional Mass Spectrometry-Based Platform. J Proteome Res., 14(11):4776-91.
Ye H, Mandal R, Catherman A, Thomas PM, Kelleher NL, Ikonomidou C, Li L*. Top-down proteomics with mass spectrometry imaging: a pilot study towards discovery of biomarkers for neurodevelopmental disorders. PLoS One, 9(4):e92831.
Ye H, Wang J, Greer T, Strupat K, Li L.* Visualizing neurotransmitters and metabolites in the central nervous system by high resolution and high accuracy mass spectrometric imaging. ACS Chem Neurosci, 4(7):1049-56.
Ye H, Gemperline E, Venkateshwaran M, Chen R, Delaux PM, Howes-Podoll M, Ané JM, Li L.* MALDI mass spectrometry-assisted molecular imaging of metabolites during nitrogen fixation in the Medicago truncatula-Sinorhizobium meliloti symbiosis. Plant J., 75(1):130-45. IF=6.16
Ye H‡, Hui L‡, Kellersberger K, Li L.* Mapping of neuropeptides in the crustacean stomatogastric nervous system by imaging mass spectrometry. J Am Soc Mass Spectrom., 24(1):134-47.
Ye H‡, Gemperline E‡, Li L.* A vision for better health: mass spectrometry imaging for clinical diagnostics. Clin Chim Acta, 420:11-22.
Ye H‡, Greer T‡, Li L.* Probing neuropeptide signaling at the organ and cellular domains via imaging mass spectrometry. J Proteomics, 75(16):5014-26.
Ye H‡, Greer T‡, Li L.* From pixel to voxel: a deeper view of biological tissue by 3D mass spectral imaging. Bioanalysis, 3(3):313-32.
‡ The authors contributed equally to this work.
目前担任中国药理学会药代动力学委员会青年委员、江苏省药理学会理事及青年委员会秘书长、Female in MS (FeMS)联络委员会co-chair。