个人简历

2003年毕业于中国药科大学药理学专业，进入新药筛选中心从事新药筛选相关工作，2014年获得中国药科大学药理学博士学位。2004年2-5月，赴中国医学科学院北京药物所新药筛选中心学习高通量筛选，2010年1-2月，赴英国剑桥培训高内涵筛选技术，2016年12-2017年12月，获得国家留学基金委资助赴美国人口学会Poulation Council's Center for Biomedical Research交流访问，学习生殖毒理学研究技术。期间承担建立了中心高通量药物筛选实验室和相关的技术管理规范，负责G蛋白偶联受体、激酶、蛋白酶、肝药酶等317个药物活性筛选模型的对外服务。目前主要从事新药筛选新技术开发应用，先导化合物、药物的药理毒理机制研究。在抗炎、生殖内分泌药物研究方面有一定的工作基础和实践经验。

研究领域

分子药理学/毒理学/高通量高内涵药物筛选

近期论文

1) Ling Shen#, Ming Yan#, Ling He, D5 receptor agonist 027075 promotes cognitive function recovery and neurogenesis in a Aβ1-42-induced mouse model. Neuropharmacology 2016(105):72-83
2) Wang, Y.#, Yan, M.#, Zheng, G.Y., He, L., Yang, H., 2014. A cell-based, high-throughput homogeneous time-resolved fluorescence assay for the screening of potential kappa-opioid receptor agonists. Acta Pharmacol Sin 2014,35, 957-966.
3) 严明，何玲，张陆勇. 新药筛选研究进展。中国药学年鉴，2012，P19-P23
4) 严明，王静宜，胡洁，苗靖姗，何玲，张陆勇。血管内皮生长因子受体-2抑制剂高通量筛选模型的建立和应用。中国药学杂志，2012,47（11）：894-898
5) 严明，张陆勇，孙丽新，江振洲，李萍，张尊建，肖小河，叶祖光。SD大鼠经口给予大黄总蒽醌的基因表达差异和肾脏毒性靶点研究，中国药学杂志,2008, 43(1):7-11
6) Ming Yan, Lu-Yong Zhang, Li-Xin Sun, Zhen-Zhou Jiang, Xiao-He Xiao Nephrotoxicity study of Total Rubarb Anthraquinons on Sprague Dawley rats using DNA microarrays，Journal of Ethernopharmacology, 2006, 107:308-311
7) Xiang Wang#, Fang Zhao#, Zhong-ming Lv, Wei-qin Shi, Lu-yong Zhang*, Ming Yan*. Triptolide disrupts the actin-based Sertoli-germ cells adherens junctions by inhibiting Rho GTPases expression，Toxicology and Applied Pharmacology, 2016, 310(1): 32–40
8) Qin-Wei YU#, Jie HU#, Hao WANG, Xin CHEN, Fang ZHAO, Peng GAO, Qiu-Bin YANG, Dan-Dan SUN, Lu-Yong ZHANG*, Ming YAN*, Antagonistic effects of extracts from Artemisia rupetris L. and Leontopodium leontopodioides to CC chemokine receptor 2b (CCR2b), Chinese Journal of Natural Medicines, 2016,14(5): 363–369
9) Jie Hu, Qinwei Yua, Fang Zhao, Jinzi Ji, Zhenzhou Jiang, Xin Chen, Peng Gao, Yuran Ren, Shuai Shao, Luyong Zhang*, Ming Yan*, Protection of Quercetin against Triptolide-induced apoptosis by suppressing oxidative stress in rat Leydig cells.Chemico-Biological Interactions,2015,240(5):38–46
10) Xin Chen, Jingshan Miao, Hao Wang, Fang Zhao, Jie Hua, Peng Gao, Yue Wang, Luyong Zhang*, Ming Yan*, The anti-inflammatory activities of Ainsliaea fragrans champ. Extract and its components in lipopolysaccharide-stimulated RAW264.7 macrophages through inhibition of NF-κB pathway, Journal of Ethnopharmacology, 2015, 170(21): 72–80
11) Ji, J.Z., Lao, K.J., Hu, J., Pang, T., Jiang, Z.Z., Yuan, H.L., Miao, J.S., Chen, X., Ning, S.S., Xiang, H., Guo, Y.M., Yan, M.*, Zhang, L.Y*., 2014. Discovery of novel aromatase inhibitors using a homogeneous time-resolved fluorescence assay. Acta Pharmacol Sin 2014,35, 1082-1092.
12) Zeng Wu, Ming Yan, Shi-He Hu, Zhi-Cheng Yu, Yong Zhu, Ya-Dong Cheng, Hai-Chun Liu, Yan-Min Zhang, Si-Hui Yao, Wei-Fang Tang, Tao Lu, Design, synthesis and biological evaluation of indole derivatives as novel inhibitors targeting B-Raf kinase.Chinese Chemical Letters, 2014,25(2): 351-354.
13) Wang, C., He, L., Yan, M., Zheng, G.Y., Liu, X.Y., Effects of polyprenols from pine needles of Pinus massoniana on ameliorating cognitive impairment in a D-galactose-induced mouse model. Age 2014, 36, 9676.
14) Hou, J., Dong, H., Yan, M., Zhu, F., Zhang, X., Wang, H., Ye, W., Li, P., New guaiane sesquiterpenes from Artemisia rupestris and their inhibitory effects on nitric oxide production. Bioorg Med Chem Lett 2014,24, 4435-4438.
15) Hu, J., Yan, M., Pu, C., Wang, J., Van den Steen, P.E., Opdenakker, G., Xu, H., Chemically synthesized matrix metalloproteinase and angiogenesis-inhibiting peptides as anticancer agents. Anti-cancer agents in medicinal chemistry 2014,14, 483-494.
16) Liu FY, Wang YJ, Yan M,, Zhang LY, Pang T, Liao L. Glimepiride attenuates Aβ production via suppressing BACE1 activity in cortical neurons. Neurosci. Lett. 2013, 557: 90-94.
17) Zhou Tao-Tao, He Ling, Yan Ming, Zhang Lu-yong, He Jian-Guo, Rao Xiao-Ping. Tyrosine kinase hinhibitory activity of dehydroabietylamine derivatives tested by homogeneous time-resolved fluorescence based high throughput screening model. Chinese Journal of Natural Medicines. 2013,11(5):0506-0513
18) Yang H, He L, Yan M, He JG, Yu T. High Throughput Screening and Structure-Activity Relationship Study of Potential α2A-Adrenoceptor Agonists by LANCETM cAMP Assay. Comb Chem High Throughput Screen. 2013 Jun 28;16(7):522-30.
19) Zhonghui Li, Ming Yan, Zhoumin Li, Maika Vuki, Dan Wu, Fei Liu, Wenying Zhong, Luyong Zhang, Danke Xu, A multiplexed screening method for agonists and antagonists of the estrogen receptor protein. Anal Bioanal Chem.2012, 403(5):1373-84
20) Zheng Qiu, Ming Yan, Qian Li, Datao Liu, Philippe E. Van den Steen, Min Wang, Ghislain Opdenakker, Jialiang Hu. Definition of peptide inhibitors from a synthetic peptide library by targeting gelatinase B/matrix metalloproteinase-9(MMP-9) and TNF-α converting enzyme (TACE/ADAM-17). Journal of Enzyme inhibition and Medicinal Chemistry，2012.4（27）：533-540
21) Xue M, Jiang ZZ, Wu T, Yan M, Liu JP, Mu XM, Su YW, Zhang LY. Protective effects of tripterygium glycoside-loaded solid lipid nanoparticles on male reproductive toxicity in rats. Arzneimittelforschung. 2011;61(10):571-6
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