个人简历

徐明，博士，副教授，硕士生导师。2006年获安徽医科大学药理学硕士学位，2009年获中国药科大学药理学博士学位。2009年8月赴美国Virginia Commonwealth University从事博士后研究，2014年9月作为海外高层次引进人才进入中国药科大学工作。至今已发表SCI期刊论文23篇，其中第一作者论文13篇。多次参加国际学术会议，在The FASEB Journal和Hypertension发表会议论文16篇。目前主持中国药科大学高层次引进人才启动基金（项目批准号：1050010016）和国家自然科学基金面上项目（项目批准号：81570413）。参与全国高等学校药学专业第八轮规划教材《药学服务概论》编写。

研究领域

1.合理用药与临床药物评价
2. 心血管药理学

近期论文

Xu M, Zhang QF, Li PL, Nguyen T, Li X, Zhang Y. Regulation of dynein-mediated autophagosomes trafficking by acid sphingomyelinase in coronary arterial smooth muscle cells: Role of TRPML1. Frontiers in Bioscience. 2015(Accepted)
Xu M, Li XX, Wang L, Wang M, Zhang Y, Li PL.Contribution of Nrf2 to Atherogenic Phenotype Switching of Coronary Arterial Smooth Muscle Cells Lacking CD38 Gene.Cell Physiol Biochem. 2015; 37:432-44.
Xu M, Li XX, Chen Y, Pitzer AL, Zhang Y, Li PL. Enhancement of dynein-mediated autophagosome trafficking and autophagy maturation by ROS in mouse coronary arterial myocytes. J Cell Mol Med. 2014; 18(11):2165-75.
Zhang Y, Xu M(共同第一作者), Xia M, Li X, Boini KM, Wang M, Gulbins E, Ratz PH, Li PL. Defective autophagosome trafficking contributes to impaired autophagic flux in coronary arterial myocytes lacking CD38 gene. Cardiovasc Res. 2014; 102(1):68-78.
Xu M, Li XX, Xiong J, Xia M, Gulbins E, Zhang Y, Li PL. Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes. Biochim Biophys Acta. 2013; 1833(12):3228-36.
Xu M, Li XX, Ritter JK, Abais JM, Zhang Y, Li PL. Contribution of NADPH oxidase to membrane CD38 internalization and activation in coronary arterial myocytes. PLoS One. 2013; 8(8):e71212.
Xu M, Li X, Walsh SW, Zhang Y, Abais JM, Boini KM, Li PL. Intracellular two-phase Ca2+ release and apoptosis controlled by TRP-ML1 channel activity in coronary arterial myocytes. Am J Physiol Cell Physiol. 2013; 304(5):C458-66.
Xu M, Xia M, Li XX, Han WQ, Boini KM, Zhang F, Zhang Y, Ritter JK, Li PL. Requirement of translocated lysosomal V1 H(+)-ATPase for activation of membrane acid sphingomyelinase and raft clustering in coronary endothelial cells. Mol Biol Cell. 2012; 23(8):1546-57.
Xu M, Zhang Y, Xia M, Li XX, Ritter JK, Zhang F, Li PL.NAD(P)H oxidase-dependent intracellular and extracellular O2•- production in coronary arterial myocytes from CD38 knockout mice. Free Radic Biol Med. 2012; 52(2):357-65.
Xu M, Tang YQ, Dai DZ, Zheng YF, Cheng YS, Zhang Q, Dai Y. Comparison of sildenafil with strontium fructose diphosphate in improving erectile dysfunction against upregulated cavernosal NADPH oxidase, protein kinase Cå, and endothelin system in diabetic rats. J Pharm Pharmacol. 2012; 64(2):244-51.
Xu M, Dai DZ, Zhang Q, Cheng YS, Dai Y. Upregulated NADPH oxidase contributes to diabetic testicular complication and is relieved by strontium fructose 1,6-diphosphate. Exp Clin Endocrinol Diabetes. 2010; 118(7):459-65.
Xu M, Ji H, Dai DZ, Tang XY, Dai Y. Protective effect of the endothelin antagonist CPU0213 against isoprenaline-induced heart failure by suppressing abnormal expression of leptin, calcineurin and SERCA2a in rats. J Pharm Pharmacol. 2008; 60(6):739-45.
Xu M, Dai DZ, Dai Y. Normalizing NADPH Oxidase Contributes to Attenuating Diabetic Nephropathy by a Dual Endothelin Receptor Antagonist CPU0213 in Rats. Am J Nephrol. 2008; 29(3):252-6.
Xia M, Boini KM, Abais JM, Xu M, Zhang Y, Li PL. Endothelial NLRP3 inflammasome activation and enhanced neointima formation in mice by adipokine visfatin. Am J Pathol. 2014; 184(5):1617-28.
Li X, Xu M, Pitzer AL, Xia M, Boini KM, Li PL, Zhang Y. Control of autophagy maturation by acid sphingomyelinase in mouse coronary arterial smooth muscle cells: protective role in atherosclerosis. J Mol Med (Berl). 2014; 92(5):473-85.
Xiong J, Xia M, Xu M, Zhang Y, Abais JM, Li G, Riebling CR, Ritter JK, Boini KM, Li PL. Autophagy maturation associated with CD38-mediated regulation of lysosome function in mouse glomerular podocytes. J Cell Mol Med. 2013; 17(12):1598-607.
Wei YM, Li X, Xu M, Abais JM, Chen Y, Riebling CR, Boini KM, Li PL, Zhang Y. Enhancement of autophagy by simvastatin through inhibition of Rac1-mTOR signaling pathway in coronary arterial myocytes. Cell Physiol Biochem. 2013; 31(6):925-37.
Boini KM, Xia M, Abais JM, Xu M, Li CX, Li PL. Acid sphingomyelinase gene knockout ameliorates hyperhomocysteinemic glomerular injury in mice lacking cystathionine-β-synthase. PLoS One. 2012; 7(9):e45020.
Han WQ, Xia M, Xu M, Boini KM, Ritter JK, Li NJ, Li PL. Lysosome fusion to the cell membrane is mediated by the dysferlin C2A domain in coronary arterial endothelial cells. J Cell Sci. 2012; 125(Pt 5):1225-34.
Han WQ, Xia M, Zhang C, Zhang F, Xu M, Li NJ, Li PL.SNARE-mediated rapid lysosome fusion in membrane raft clustering and dysfunction of bovine coronary arterial endothelium.Am J Physiol Heart Circ Physiol. 2011 ;301(5):H2028-37.
Zhang F, Xu M, Han WQ, Li PL. Reconstitution of lysosomal NAADP-TRP-ML1 signaling pathway and its function in TRP-ML1(-/-) cells. Am J Physiol Cell Physiol. 2011; 301(2):C421-30.
Jin Y, Xu Y, Xue S, Liu H, Zhao J, Xu M. Predicting the development of early skin test sensitization in offspring of parents with asthma. Eur J Clin Invest. 2007; 37(6):522-7.
Jin Y, Xu Y, Xu M, Xue S. Increased risk of cancer among relatives of patients with lung cancer in China. BMC Cancer. 2005; 11(5):146.