个人简历

王丽蕊，教授，博士生导师。2011年获中科院上海药物研究所药理学博士学位，同年7月加入上海药明康德新药研发有限公司任高级研究员，2012年3月前往美国加州大学圣地亚哥分校医学院进行博士后研究，2016年入选“中国药科大学海外高层次人才引进计划”、“江苏省特聘教授”，加入中国药科大学基础医学与临床药学学院。2017年入选江苏省“六大高峰人才计划、江苏省双创团队核心成员。已在Cell Host & Microbe、PNAS、Hepatology、Journal of Hepatology、Journal of Clinical Investigation、Nature Communications等国际著名期刊上发表论文20余篇，其中发表在Cell Host & Microbe上的论文成为Nature Reviews Gastroenterology &Hepatology的亮点文章，并受到世界主流新闻媒体，包括美国国家电视台NBC7、新闻期刊The Economist、Science Daily、德国广播中心等的采访及报道，现为多个国际生物医学及药理学期刊特邀审稿人。研究获中国药科大学双一流创新团队项目（CPU2018GF10，CPU2018GY31），江苏省特聘教授和江苏省双创团队资金、国家自然科学基金青年项目（81700748），科技部国家重点研发计划（2018YFC1704905）的资助。

研究领域

揭示酒精性肝病（ALD）、非酒精性脂肪性肝病（NAFLD）、肝纤维化（Liver fibrosis）等慢性非传染性肝病发病机理并探索相应的治疗策略

近期论文

Hartmann P, Seebauer CT, Mazagova M, Horvath A, Wang L, Llorente C, Varki NM, Brandl K, Ho SB, Schnabl B. Deficiency of intestinal mucin-2 protects mice from diet-induced fatty liver disease and obesity.Am J Physiol Gastrointest Liver Physiol. 2016 Mar 1;310(5):G310-22. PMID: 26702135 (IF=3.798)
Inamine T, Yang AM, Wang L, Lee KC, Llorente C, Schnabl B. Immunoglobulin A deficiency does not affect development of alcoholic steatohepatitis in mice.Alcohol Clin Exp Res. 2016 (IF=2.8)
Hartmann P, Chen P, Wang HJ, Wang L, McCole DF, Brandl K, Stärkel P, Belzer C, Hellerbrand C, Tsukamoto H, Ho SB, Schnabl B. Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice.Hepatology. 2013 Jul;58(1):108-19. PMID:23408358 (IF=14.079)
Han C, Wang L, Yu K, Chen L, Hu L, Chen K, Jiang H, Shen X. Biochemical characterization and inhibitor discovery of shikimate dehydrogenase from Helicobacter pylori.FEBS J. 2006 Oct; 273(20):4682-92. PMID:16972983 (IF=4.001)
Yang AM, Inamine T, Hochrath K, Chen P, Wang L, Llorente C, Bluemel S, Hartmann P, Xu J, Koyama Y, Kisseleva T, Torralba MG, Moncera K, Beeri K, Chen CS, Freese K, Hellerbrand C, Lee SM, Hoffman HM, Mehal WZ, Garcia-Tsao G, Mutlu EA, Keshavarzian A, Brown GD, Ho SB, Bataller R, Stärkel P, Fouts DE, Schnabl B. Intestinal fungi contribute to development of alcoholic liver disease. J Clin Invest. 2017 Jun 30;127(7):2829-2841. (IF= 13.251)
Hartmann P, Hochrath K, Horvath A, Chen P, Seebauer CT, Llorente C, Wang L, Alnouti Y, Fouts DE, Stärkel P, Loomba R, Coulter S, Liddle C, Yu RT, Ling L, Rossi SJ, DePaoli AM, Downes M, Evans RM, Brenner DA, Schnabl B. Modulation of the intestinal bile acid-FXR-FGF15 axis improves alcoholic liver disease in mice. Hepatology. 2017 Nov 21. (IF= 14.079)
Llorente C, Jepsen P, Inamine T, Wang L, Bluemel S, Wang HJ, Loomba R, Bajaj JS, Schubert ML, Sikaroodi M, Gillevet PM, Xu J, Kisseleva T, Ho SB, DePew J, Du X, Sørensen HT, Vilstrup H, Nelson KE, Brenner DA, Fouts DE, Schnabl B. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Nat Commun. 2017 Oct 16;8(1):837. (IF= 12.353)
Sena Bluemel, Lirui Wang, Cameron Martino, Suhan Lee, Yanhan Wang, Brandon Williams, Angela Horvath, Vanessa Stadlbauer, Karsten Zengler, Bernd Schnabl. The Role of Intestinal C‐type Regenerating Islet Derived‐3 Lectins for Nonalcoholic Steatohepatitis. Hepatol Commun. 2018 Apr; 2(4): 393–406. Published online 2018 Feb 28. doi: 10.1002/hep4.1165
Wang L, Mazagova M, Pan C, Yang S, Brandl K, Liu J, Reilly SM, Wang Y, Miao Z, Loomba R, Lu N, Guo Q, Liu J, Yu RT, Downes M, Evans RM, Brenner DA, Saltiel AR, Beutler B, Schnabl B.YIPF6 controls sorting of FGF21 into COPII vesiclesand promotes obesity. Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15184-15193. (IF=9.58)
Qian M, Lyu Q, Liu Y, Hu H, Wang S, Pan C, Duan X, Gao Y, Qi LW, Liu W, Wang L.Chitosan oligosaccharide ameliorates nonalcoholic fatty liver disease (NAFLD) in diet-induced obese mice. Marine Drugs. 2019 Jul 2;17(7). (IF=3.744)
Bluemel S, Wang L, Kuelbs C, Moncera K, Torralba M, Singh H, Fouts DE, Schnabl B. Intestinal and hepatic microbiota changes associated with chronic ethanol administration in mice. Gut Microbes. 2019 Apr 14:1-11. (IF=7.823)
Zhang, Yuan, Rongrong Huang, Mengjing Cheng, Lirui Wang, Jie Chao, Junxu Li, Peng Zheng, Peng Xie, Zhijun Zhang, Honghong Yao. Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2. Microbiome. 2019 Aug 22;7(1):116. (IF=10.465)