个人简历

孙宏斌，男，出生于1966年12月。教育部“长江学者”特聘教授、“天然药物活性组分与药效”国家重点实验室副主任、江苏省代谢性疾病药物重点实验室主任、药物科学研究院新药研究中心主任、江苏省药学会药物化学专业委员会副主任委员、中国药科大学学位评定委员会和学术委员会委员。担任Recent Patents on Anti-Cancer Drug Discovery（IF 2.7）（地区编委）、Drug Discoveries & Therapeutics、药学学报（英文版）、 中国药物化学杂志 、 药物化学进展（丛书）和中国药科大学学报编委。入选教育部“新世纪优秀人才”（2005年）和江苏省“333高层次人才培养工程”第二层次培养对象(2013年)，获中国药学会“施维雅青年药物化学奖”（2006年）和EFSD (European Foundation for the Study of Diabetes) Grant Awards for Collaborative Diabetes Research between China and Europe（2007年）。
1989年毕业于吉林大学化学系获学士学位（有机化学）；1995年获中国药科大学博士学位（药物化学）；1995-1998年先后在中科院上海有机化学研究所和德国亚琛工业大学有机化学研究所从事博士后研究；1998-2001年在美国佛罗里达大学化学系做访问学者；2001-2003年在美国加州Metabolex公司从事新药研究，在此期间所设计合成的化合物MBX-2044作为抗糖尿病新药已完成IIa期临床试验；2003年8月回国任中国药科大学教授；2008年10月兼任法国Cachan高等师范学院Visiting Professor。

研究领域

长期从事药物化学、有机合成化学和新药研究，尤其是在五环三萜的化学、生物学及新药研究方面具有一定的影响力

近期论文

1. Zengwei Lai, Chunhong Li, Jun Liu, Lingyi Kong, Xiaoan Wen,* Hongbin Sun.* Discovery of Highly Potent DPP-4 Inhibitors by Hybrid Compound Design Based on Linagliptin and Alogliptin. European Journal of Medicinal Chemistry 2014, 83, 547-560.
2. Jizhe Dong, Yanchun Gong, Jun Liu, Xiangfeng Chen, Xiaoan Wen,* Hongbin Sun.* Synthesis and biological evaluation of all eight stereoisomers of DPP-IV inhibitor saxagliptin. Bioorganic & Medicinal Chemistry 2014, 22, 1383-1393.
3. Dongyin Chen, Chang Xu, Jie Deng, Chunhuan Jiang, XiaoanWen, Lingyi Kong, Ji Zhang,* Hongbin Sun,*Proton-exchanged montmorillonite-mediated reactions of methoxybenzyl esters and ethers. Tetrahedron2014, 70, 1975-1983.
4. Xiaowei Sun, Chengzhe Gao, Fan Zhang, Zhuang Song, Lingyi Kong, Xiaoan Wen, Hongbin Sun.* Electronic and Steric Effects on the Intramolecular Schmidt Reaction of Alkyl Azides with Secondary Benzyl Alcohols.Tetrahedron2014, 70, 643-649.
5. Zeng-Wei Lai, Rong-Fei Yang, Ke-Yin Ye, Hongbin Sun,* Shu-Li You.* Synthesis of 1-[bis(trifluoromethyl)phosphine]-1’-oxazolinylferrocene ligands and their application in regio- and enantioselective Pd-catalyzed allylic alkylation of monosubstituted allyl substrates. Beilstein Journal of Organic Chemistry2014, 10, 1261-1266.
6. Xueli Zhang, Yanli Tian, Zeng Li, Xiaoyu Tian, Hongbin Sun, Hong Liu, Anna Moore, Chongzhao Ran*. Design and synthesis of curcumin analogues for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid Beta species in Alzheimer's disease. J. Am. Chem. Soc. 2013, 135, 16397-409.
7. Jia Hao,Jun Liu, Xiaoan Wen, Hongbin Sun.* Synthesis and cytotoxicity evaluation of oleanolic acid derivatives.Bioorganic & Medicinal Chemistry Letters2013, 23, 2074-2077.
8. Jiaqi Shan, Hongbin Sun.* The discovery and development of Prasugrel. Expert Opinion on Drug Discovery2013, 8, 897-905.
9. Jia Hao,Jun Liu, Xiaoan Wen, Hongbin Sun.* Synthesis and cytotoxicity evaluation of oleanolic acid derivatives.Bioorganic & Medicinal Chemistry Letters2013, 23, 2074-2077.
10. Jiaqi Shan, Boyu Zhang, Yaoqiu Zhu, Bo Jiao, Weiyi Zheng, Xiaowei Qi, Yanchun Gong,Fang Yuan, Fusheng Lv, Hongbin Sun.* Overcoming Clopidogrel Resistance: Discovery of Vicagrel as a Highly Potent and Orally Bioavailable Antiplatelet agent. Journal of Medicinal Chemistry2012, 55, 3342–3352.（获Nature旗下刊物SciBX的亮点报道）
11. Jia Hao,Bo Chen,Yiwu Yao, Murad Hossain, Takafumi Nagatomo, Hequan Yao,Lingyi Kong, Hongbin Sun.* Practical access to four stereoisomers of naftidrofuryl and their binding affinity towards 5-hydroxytryptamine 2A receptor. Bioorganic & Medicinal Chemistry Letters2012, 22, 3441-3444.
12. Hao Zhang, Jun Liu, Luyong Zhang, Lingyi Kong, Hequan Yao, Hongbin Sun.*Synthesis and biological evaluation of ticagrelor derivatives as novel antiplatelet agents. Bioorganic & Medicinal Chemistry Letters2012, 22, 3598-3602.
13. Liying Zhang, Yingxia Zhang, Jizhe Dong, Jun Liu*, Luyong Zhang, Hongbin Sun.*Design and synthesis of novel photoaffinity probes for study of the target proteins of oleanolic acid. Bioorganic & Medicinal Chemistry Letters2012, 22, 1036-1039.
14. Jun Xia, Jiabin Li, Hongbin Sun.* Insights into ETA subtype selectivity of benzodiazepine endothelin receptor antagonists by 3D-QSAR approaches. Journal of Molecular Modeling2012, 18, 1299-1311.
15. Huaming Sheng,Hongbin Sun.* Synthesis, Biology and Clinical Significance of Pentacyclic Triterpenes: a Multi-target Approach to Prevention and Treatment of Metabolic and Vascular Diseases. Natural Product Reports 2011, 28, 543-593.
16. Zhangyu Yao, Xueying Wei, Xiaoming Wu, Jonathan L. Katz, Theresa Kopajtic, Nigel H. Greig, Hongbin Sun.*Preparation and Evaluation of Tetrabenazine Enantiomers and All Eight Stereoisomers of Dihydrotetrabenazine as VMAT2 Inhibitors. European Journal of Medicinal Chemistry 2011, 46, 1841-1848.
17.Zhongjie Liang, Liying Zhang, Lianchun Li, Jun Liu, Honglin Li, Luyong Zhang，Keguang Cheng, Xiaoan Wen, Pu Zhang, Jia Hao, Yanchun Gong, Xia Zhang, Jun Chen, Hong Liu, Cheng Luo, Hualiang Jiang,Hongbin Sun.* Pentacyclic Triterpenes Derivatives as Potent Inhibitors against Glycogen Phosphorylase: the Receptor-Based 3D-QSAR Guided Inhibitor Optimization. European Journal of Medicinal Chemistry 2011, 46, 2011-2021.
18. Yong Wu, Chen Shi, Xiaowei Sun, Xiaoming Wu, Hongbin Sun.* Synthesis, biological evaluation and docking studies of octane-carboxamide based renin inhibitors with extended segments toward S3’ site of rennin.Bioorganic & Medicinal Chemistry2011, 19, 4238-4249.
19. Pu Zhang, Li Xu, Keduo Qian, Jun Liu, Luyong Zhang, Kuo-Hsiung Lee, Hongbin Sun.* Efficient synthesis and biological evaluation of epiceanothic acid and related compounds. Bioorganic & Medicinal Chemistry Letters2011, 21, 338-341.
20. Jun Xia , Jianfei Song, Le Zhen, Xiuling Zhang, Xiantao Lei, Lina Zheng, Qiujuan Wang, Hongbin Sun.* Synthesis and in vitro evaluation of ambrisentan analogues as potential endothelin receptor antagonists. Bioorganic & Medicinal Chemistry Letters2011, 21, 3894-3897.