个人简历

李运曼（1957- ），女，教授，博士生导师，基础医学与临床药学学院基础医学系副主任。1982年12月本科毕业于山东大学医学院医学系，并获得学士学位。2005年6月毕业于博士毕业于中国药科大学药理专业，并获理学博士学位。1982年12月进入中国药科大学从事心血管药物及肿瘤多药耐药逆转剂的药理研究。自2001年-2005年连续5年享受中国药科大学校特殊津贴。2011年被评为江苏省优秀硕士学位论文指导老师。主持或承担国家和省级科研课题20余项，在国内外核心期刊发表科研和教学论文100余篇，其中被SCI收载论文40余篇。江苏省生理学会常务理事，南京药学会第九届药理毒理专业委员会副主任委员，江苏省药理学会理事，中国药理学会心血管药理专业委员会第十一届委员会委员，国家保健食品审评专家，国家科技奖励评审专家，国家863计划基金评审专家，国家自然科学基金评审专家，国家发改委药品价格评审专家，江苏省药品保健食品审评专家。中南药学编委及审稿专家，中国临床药理学与治疗学审稿专家，Journal of Experimental &Clinical Cancer Research、JournalofPharmacyandPharmacology、Acta Pharmacologica Sinica、中国药理学通报、中国新药杂志和中国药科大学学报审稿专家。

研究领域

心脑血管药理：主要研究抗脑缺血、抗心肌缺血创新药物的药效学作用及作用信号通路或靶点；研究宽治疗时间窗的抗缺血性脑卒中和出血性脑卒中的创新药物；研究炎症因子、氧化应激、免疫与脑缺血、心肌缺血、高血脂动脉粥样硬化及高血压的关系及其药物干预，研究星形胶质细胞和小胶质细胞在缺血性脑损伤中的作用及其药物干预等

近期论文

1、Yan Deng, Weirong Fang, Yunman Li(通讯作者), Juan Cen, Fang Fang, Peng Lv, Shubo Gong, Lishun Mao. Blood-brain barrier breakdown by PAF and protection by XQ-1H due to antagonism of PAF effects. European Journal of Pharmacology, 2009, 616 (1-3): 43-47. IF 2.787
2、Juan Cen, Yan Qi, Yunman Li(通讯作者), Weirong Fang, Yan Deng, Lu-yong Zhang, Wenlong Huang.HZ08, a great regulator to reverse multidrug resistance via cycle arrest and apoptosis sensitization in MCF-7/ADM. European Journal of Pharmacology. 2010; 647（1-3）: 21-30.IF 2.787
3、Zhen X, Cen J, Li YM（通讯作者）, Yan F, Guan T, Tang XZ. Cytotoxic effect and apoptotic mechanism of tanshinone A, a novel tanshinone derivative, on human erythroleukemic K562 cells. Eur J Pharmacol. 2011; 667(1-3): 129-35. IF 2.787
4、Fang W, Geng X, Deng Y, Li Y(通讯作者), Shang E, Cen J, Lv P: Platelet activating factor induces blood brain barrier permeability alteration in vitro. J Neuroimmunol, 2011, 230(1-2):42-47. IF 2.98
5、Jing Xiong1,2, Virginia M. Miller2,3*, Larry W. Hunter2,Yunman Li1*(通讯作者), Muthuvel Jayachandran3.Leukocyte- and Platelet-Derived Microvesicle Interactions following In Vitro and In Vivo Activation of Toll-Like Receptor 4 by Lipopolysaccharide. PLoS ONE.September 2011 | Volume 6 | Issue 9. IF 4.411
6、Lv P,Fang W, Geng X, Yang Q, Li Y（通讯作者）, Sha L. Therapeutic neuroprotective effects of ginkgolide B on cortex and basal ganglia in a rat model of transient focal ischemia. Eur J Pharm Sci. 2011; 44(3): 235-40。IF 3.291
7、Sun J, Li Y（通讯作者）, Fang W, Mao L. Therapeutic time window for treatment of focal cerebral ischemia reperfusion injury with XQ-1h in rats. Eur J Pharmacol. 2011; 666(1-3): 105-10.IF 2.787
8、Longfei Huang a,1, Teng Guan a,1, Yisong Qian a,1, Yunman Lia（通讯作者）, Hongbin Sun b.Anti-inflammatory effects of maslinic acid, a natural triterpene, in cultured cortical astrocytes via suppression of nuclear factor-kappa B. Eur J Pharmacol. 672 (2011) 169–174.IF ：2.787
9、Jing Xiong a,b,1, Li Baib,1, Wei Fang c, Jianyang Fu b, Weirong Fang b, Juan Cen b, Yi Kong d,*, Yunman Lib,*（通讯作者）. New peptide pENW (pGlu-Asn-Trp) inhibits platelet activation by attenuating Akt phosphorylation. European Journal of Pharmaceutical Sciences.45 (2012) 552–558.IF ：3.2
10、Menghao Huang 1, Yisong Qian 1, Teng Guan 1, Longfei Huang, Xuzhen Tang, Yunman Li （通讯作者）*.Different neuroprotective responses of Ginkgolide B and bilobalide, the two Ginkgo.European Journal of Pharmacology 677 (2012) 71–76.IF ：2.516
11、Qichuan Yang， Weirong Fang ， Peng Lv， Xiaohan Geng ，Yunman Li*（通讯作者）Lan Sha. Therapeutic Neuroprotective Effects of XQ-1H in a Rat Model of Permanent Focal Cerebral Ischemia. Pharmacology 2012;89:1–6.IF ：1.82
12、Qian, Yisong, Guan, Teng, Huang, Menghao, Cao, Liangxun, *Li, Yunman（通讯作者）, Cheng, Hao, Jin, Hangxia, Yu, Deyue，Neuroprotection by the soy isoflavone, genistein, via inhibition of mitochondria-dependent apoptosis pathways and reactive oxygen induced-NF-kappa B activation in a cerebral ischemia mouse model[J]，Neurochemistry International, 60(8), pp 759-767, 2012/6.期刊论文，IF ：2.857
13、Weirong Fang, Peng Lv, Xiaohan Geng, Erxin Shang, Qichuan Yang, Lan Sha, Yunman Li（通讯作者）.. Penetration of verapamil across blood brain barrier following cerebral ischemia depending on both paracellular pathway and P-glycoprotein transportation. Neurochem Int.62 (2013) 23–30 . IF 2.857。
14、Yidong Feng a, Yahui Hu a, Juan Cen a, Kodithuwakku Nandani Darshika a
, Weirong Fang a，Yunman Lia*（通讯作者）, Wenlong Huang b.HZ08 inhibits the multi-drug resistance on multiple sites as the substrate of p-glycoprotein.European Journal of Pharmacology 712 (2013) 53–59.IF：2. 592
15、Yi-dong Feng, Wei-rong Fang,Yun-man Li（通讯作者）. HZ08 inhibits the multi-drug resistance on multiple sites as the substrate of p-glycoprotein. [J]. Acta Pharmacol Sin，Vol.34,Supplement July 2013. IF：2.51
16. Jie Wei, Weirong Fang, Lan Sha, Dan Han, Rui Zhang, Xin Hao, Yunman Li（通讯作者）. XQ-1H suppresses neutrophils infiltration and oxidative stress induced by cerebral ischemia injury both in vivo and in vitro. Neurochem Res. IF 2.125
17、Weirong Fang, Rui Zhang, Lan Sha, Peng Lv, Erxin Shang, Dan Han, Jie Wei, Xiaohan Geng, Qichuan Yang, Yunman Li（通讯作者）. Platelet activating factor induces transient blood-brain barrier opening to facilitate edaravone penetration into the brain. J Neurochem. (2014) 128, 662–671。IF：3.973
18、Yan-Yan Zhanga, Ya-Hui Hua, Yi-Dong Fenga, Kodithuwakku Nandani Darshikaa, Wei-Rong Fanga, Yun-Man Lia*（通讯作者）, Wen-Long Huangb.The inhibitory and combinative mechanism of HZ08 with P-glycoprotein expressed on the membrane of Caco-2 cell line .Toxicology and Applied Pharmacology.274（2014）232-239。IF：3.973
19、Fang W, Sha L, Kodithuwakku ND, Wei J, Zhang R, Han D, Mao L, Li Y（通讯作者）. Attenuated Blood-Brain Barrier Dysfunction by XQ-1H Following Ischemic Stroke in Hyperlipidemic Rats.Mol Neurobiol.2014 Aug 17. [Epub ahead of print]，IF：5.286
20、Xiong, Y., Ma, Y., Han, W., Kodithuwakku, N.D., Liu, L.F., Li, F.W., Fang, W.R., Li, Y.M i（通讯作者）., 2014. Clematichinenoside AR induces immunosuppression involving Treg cells in Peyers patches of rats with adjuvant induced arthritis. Journal of ethnopharmacology 2014. 155(2): 1306-14. IF：2.755