个人简历

江振洲，博士，研究员，博士生导师。1998年参加工作，现工作于中国药科大学药物科学研究院科技部国家南京新药筛选中心、江苏省新药筛选重点实验室，任药物科学研究院新药筛选中心副主任。获第十四批“六大人才高峰”高层次人才选拔培养资助。主要从事分子药理/毒理学和毒代动力学研究，主要的研究方向是药源性肝脏毒性与干预及其分子机制，同时结合代谢动力学进行物质基础研究，寻找肝脏早期毒性生物标志物。已经建立了较完善规范的符合中药特点的肝毒性研究体系，在此基础上开展有毒中药、抗结核药物和雌激素调节剂等等的肝毒性作用机制和物质基础研究。主持在研国家自然科学基金面上项目2项，江苏省自然基金面上项目1项，主持完成国家自然科学基金、国家中医药管理局中医药科技研究专项等其他纵向课题7项，作为主要参与者（子课题负责人）参与1项国家自然科学基金重大国际合作研究项目，6项国家自然科学基金项目和省自然基金项目的研究，是重大新药创制中药肝毒性早期发现关键技术、中医药行业专项、综合性新药研究开发技术大平台安评子平台、重大新药创制筛选平台等多项重大纵向课题的科研骨干。获山东省科技进步奖一等奖（2015，6/12），教育部科学技术进步奖二等（2014，6/9），江苏省科技进步一等奖（2006，7/9）。发表SCI文章122篇，其中一作或（共）通讯作者SCI论文57篇，h-index为20。近4在Arch. Toxicol、Toxicological Science、Toxicology and Applied Pharmacology、Toxicology、Toxicology Letters等高水平毒理学专业杂志发表了28篇毒理相关论文，形成了具有特色的药物肝脏毒理学研究方向。

研究领域

1.药物相关性脂肪性肝病的诱发机制与干预靶点研究；
2.药源性胆汁淤积型肝病分子机制研究；
3.基于免疫代谢紊乱的药物性肝病分子机制研究

近期论文

1.Tingting Yang, Ting Shu, Guanlan Liu, Huifang Mei, Xiaoyu Zhu, Xin Huang, Luyong Zhang, Zhenzhou Jiang*. Quantitative profiling of 19 bile acids in rat plasma, liver, bile and different intestinal section contents to invstigate bile acid homeostasis and the application of temporal variation of endogenous bile acids.Journal of Steroid Biochemistry & Molecular Biology. 2017, 172:69-78.
2.Guo Hongli, Hozeifa M. Hassan, Ding Pingping, Wang Shaojie, Chen Xi, Wang Tao, Sun Lixin,Zhang Luyong*,Jiang Zhenzhou*. Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2α-ATF4-CHOP pathway.Toxicology. 2017, 378:65-75.3.Hozeifa M. Hassan, Guo Hongli, Bashir A. Yousef, Ding Pingping, Zhang Luyong*, Jiang Zhenzhou*. Dexamethasone pretreatment alleviates isoniazid/lipopolysaccharide hepatotoxicity: inhibition of inflammatory and oxidative stress.Frontier in Pharmacology. 2017, 8(133):e1-e13.
4.Yu Linxi, Liu Xiaoxin, Yuan Zihang, Li Xiaojiaoyang, Yang Hang, Yuan Ziqiao, Lixin Sun,Zhang Luyong*, Jiang Zhenzhou*. SRT1720 alleviates ANIT-induced cholestasis in a mouse model.Frontier in Pharmacology. 2017, 8(256):e1-e17.
5.Li Xiaojiaoyang, Liu Runping, Luo Lan, Yu Linxi, Chen Xin, Sun Lixin, Wang Tao, Phillip B. Hylemon,Zhou Huiping*, Jiang Zhenzhou*, Zhang Luyong*. Role of AMP‑activated protein kinase α1 in17α-ethinylestradiol‑induced cholestasis in rats.Archives of Toxicology.2017, 91:481-494.
6.Hozeifa Mohamed Hassan, Guo Hongli, Bashir Alsiddig Yousef, Mounia Guerram, Aida Mejda Hamdi, Zhang Luyong*, Jiang Zhenzhou*. Role of Inflammatory and Oxidative Stress, Cytochrome P450 2E1, and Bile Acid Disturbance in Rat Liver Injury Induced by Isoniazid and Lipopolysaccharide Cotreatment. Antimicrobial Agents and Chemotherapy. 2016, 60(9):5285-5293.
7.Guo Hongli, Hozeifa M. Hassan, Zhang Yun, Dong Sizhe, Ding Pingping, Wang Tao, Sun Lixin,Zhang Luyong*, Jiang Zhenzhou*.Pyrazinamide induced rat cholestatic liver injury through inhibition of FXR regulatory effect on bile acid synthesis and transport.Toxicological Sciences. 2016. 152(2):417-428.
8.Li Xiaojiaoyang, Liu Runping, Yu Linxi, Yuan Zihang, Sun Rong, Yang Hang, Zhang Luyong,Jiang Zhenzhou*. Alpha-naphthylisothiocyanate impairs bile acid homeostasis through AMPK-FXR pathways in rat primary hepatocytes.Toxicology. 2016, 37:106-115.
9.Li Xiaojiaoyang, Yuan Zihang, Liu Runping, Hozeifa M. Hassan, Yang Hang, Sun Rong, Zhang Luyong*, Jiang Zhenzhou*. UDCA and CDCAalleviate17α-ethinylestradiol-induced cholestasis through PKA-AMPK pathwaysin rats.Toxicology and Applied Pharmacology.2016, 311:12-25.
10.Zhang Yun#, Guo Hongli#, Hozeifa M. Hassan, Ding Pingping, Wang Tao, Sun Lixin,Zhang Luyong*, Jiang Zhenzhou*. Pyrazinamide induced hepatic injury in rats through inhibiting the PPARα pathway.Journal of Applied Toxicology. 2016, 36(12):1579-1590 .
11.Yu Linxi, Liu Xiaoxin, Li Xiaojiaoyang, Yuan Zihang, Yang Hang, Zhang Luyong*, Jiang Zhenzhou*.Protective effects of SRT1720 via theHNF1α/FXRsignalling pathway and anti-inflammatory mechanisms in mice with estrogen-induced cholestatic liver injury.Toxicology Letters.2016, 264:1-11.
12.Zhang Yun, Liu Kechun, Hozeifa M. Hassan, Guo Hongli, Ding Pingping, Han Liwen, He Qiuxia, Chen Weiyun, Chung-Der Hsiao, Zhang Luyong, Jiang Zhenzhou*. Liver Fatty Acid Binding Protein Deficiency Provokes Oxidative Stress, Inflammation, and Apoptosis-Mediated Hepatotoxicity Induced by Pyrazinamide in Zebrafish Larvae.Antimicrobial Agents and Chemotherapy. 2016, 60(12): 7347-7356.
13.Liu Runping, Li Xiaojiaoyang, Luo Lan, Qiang Xiaoyan, Phillip B. Hylemon, Jiang Zhenzhou*, Zhang Luyong*, Zhou Huiping*.Taurocholate Induces Cyclooxygenase-2 Expressionviathe Sphingosine 1-phosphate. Receptor2 ina Human Cholangiocarcinoma Cell Line.J Biol Chem. 2015, 290(52): 30988-1002.
14.Wang Xinzhi, Zhang Luyong*, Jiang Zhenzhou*. Helper T cell-mediated factors in drug-induced liver injury. Journal of Applied Toxicology. 2015, 35(7):695-700.
15.Su Yijing#, Zhang Yun#, Chen Mi, Jiang Zhenzhou*, Sun Lixin, Wang Tao, Zhang Luyong. Lipopolysaccharide exposure augments isoniazide-induced liver injury. Journal of Applied Toxicology. 2014, 34: 1436–1442. IF 2.982
16.Tai T, Huang X, Su YW, Ji JZ, Su YJ, Jiang ZZ*, Zhang LY*. Glycyrrhizin accelerates the metabolism of triptolide through induction of CYP3Ain rats.Journa of Ethnopharmacology.2014; 152:358–363. IF 2.755
17.Xinzhi Wang, Zhenzhou Jiang*, Mengtao Xing, Jing Fu, Yuwen Su, d, Lixin Sun, Luyong Zhang*. Interleukin-17 mediates triptolide-induced liver injury in mice.Food and Chemical Toxicology. 2014, 71: 33–41.
18.Xiaojiaoyang Li, Zhenzhou Jiang*, Luyong Zhang. Triptolide: Progress on research in pharmacodynamics and toxicology. Journal of Ethnopharmacology. 2014, 155(1): 67-79.
19.Jiang ZZ,Wu MJ,Miao JS, Duan HQ, Zhang S, Chen M, Sun LX, Wang YR, Zhang XJ, Zhu X,Zhang LY. Deoxypodophyllotoxin exerts both anti-angiogenic and vascular disrupting effects.The International Journal of Biochemistry & Cell Biology.2013; 45:1710– 1719.IF 4.634
20.Jiang ZZ,Bao QL,Sun LX, Huang X, Wang T, Zhang S, Li H,Zhang LY. Possible role of mtDNA depletion and respiratory chain defects in aristolochic acid I-induced acute nephrotoxicity.Toxicology and Applied Pharmacology.2013; 266: 198–203.