何华
近期热点
资料介绍
个人简历
何华,博士,副教授,硕士生导师。2013年毕业于中国药科大学药学院获博士学位。2015-2017年于美国北卡罗来纳大学教堂山分校从事博士后研究工作。研究领域
药代动力学建模与仿真。近年专注于应用药动学-药效学(PK-PD)模型、生理药动学(PBPK)模型、群体药动学(PopPK)模型以及定量系统药理学(QSP)模型等方法定量研究药物与机体之间相互作用的规律近期论文
[1]. Hua He, Can Liu, Yun Wu, Xinyuan Zhang, Jianghong Fan, Yanguang Cao*. A Multiscale Physiologically-Based Pharmacokinetic Model for Doxorubicin to Explore its Mechanisms of Cytotoxicity and Cardiotoxicity in Human Physiological Contexts. Pharm Res. 2018 Jul 9;35(9):174.[2]. Hua He, Yanguang Cao*. Chemotherapeutic dosing implicated by pharmacodynamic modeling of in vitro cytotoxic data: a case study of paclitaxel. J Pharmacokinet Pharmacodyn. 2017 Oct;44(5):491-501.[3]. Haidong Wang, Xi Li, Wenting Zhang, Yao Liu, Shijun Wang, Xiaoquan Liu*, Hua He*. Mechanism-based pharmacokinetic-pharmacodynamic modeling of salvianolic acid A effects on plasma xanthine oxidase activity and uric acid levels in acute myocardial infarction rats. Xenobiotica. 2017;47(3):208-216.[4]. Haochen Liu, Xiaoting Zhou, Hao Jiang, Hua He*, Xiaoquan Liu*. A semi-mechanism approach based on MRI and proteomics for prediction of conversion from mild cognitive impairment to Alzheimer's disease. Sci Rep. 2016;6:26712.[5]. Haidong Wang, Hao Jiang, Haochen Liu, Xue Zhang, Guimei Ran, Hua He*, Xiaoquan Liu*. Modeling disease progression: angiotensin II indirectly inhibits nitric oxide production via ADMA accumulation in spontaneously hypertensive Rats. Front Physiol. 2016; 7: 555.[6]. Haochen Liu, Chunxiang Wei, Hua He*, Xiaoquan Liu*. Evaluating alzheimer's disease progression by modeling crosstalk network disruption. Front Neurosci. 2016;9:523. 相关热点
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