个人简历

郭长缨，博士，2016年以特聘研究员引进，博士研究生导师，现就职于生命科学与技术学院。2006年毕业于中国科学院微生物研究所，获生物化学与分子生物学博士学位。同年赴美国国立卫生院老人研究所著名教授Ranjan Sen课题组进行博士后研究。主要研究内容为B细胞发育过程中免疫球蛋白重链基因VDJ重组的分子机制。2012年成为美国免疫协会会员。2013年进入哈佛医学院波士顿儿童医学院著名教授Judy Lieberman实验室进行癌症相关研究，主要包括乳腺癌细胞雌激素受体诱导的转录激活的分子机制等。迄今为止已在国际知名的生物学学术期刊发表多篇学术论文。所发表论文累计影响因子>100, 被引用次数>500。

研究领域

乳腺癌发生和转移的分子机制以及相关药物开发；
生物大分子药物递送载体的开发和改造""

近期论文

1. C Lin, Y Wang, Y Wang, S Zhang, L Yu, C Guo* and H Xu*. Transcriptional and posttranscriptional regulation of HOXA13 by lncRNA HOTTIP facilitates tumorigenesis and metastasis in esophageal squamous carcinoma cells. Oncogene. 2017. 1-15. (* co-corresponding author)
2. Lindsey Montefiori, Robert Wuerffel, Damian Roqueiro, Bryan Lajoie, Changying Guo, Tatiana Gerasimova, Supriyo De, William Wood, Kevin G. Becker, Job Dekker, Jie Liang, Ranjan Sen, Amy L. Kenter. Extremely Long-Range Chromatin Loops Link Topological Domains to Facilitate a Diverse Antibody Repertoire. Cell Reports. 14(15), 2016, 1-11.
3. Tatiana Gerasimova, Changying Guo, Amalendu Ghosh, Xiang Qiu, Lindsey Montefiori, Jiyoti Verma-Gaur, Nancy M. Choi, Ann Feeney and Ranjan Sen. A structural hierarchy mediated by multiple nuclear factors establishes IgH locus conformation. Gene & Development. 29(16), 2015. 1683-1695.
4. Minh T. N. Le, Peter Hamar, Changying Guo, Emre Basar, Ricardo Perdigão-Henriques, Leonora Balaj, Judy Lieberman* miR-200 in extracellular vesicles promotes metastasis of breast cancer cells. Journal of Clinical Investigation. 124(12), 2014, 5109-5128.
5. Jennifer E. Phillips-Cremins, Michael E. Gehring, Amartya Sanya, Tatiana Gerasimova, Bryan R. Lajoie, Joshua S. K. Bell, Chin-Tong Ong, Tracy A. Hookway, Changying Guo, Yuhua Sun Michael J. Bland, William Wagstaff, Stephen Dalton, Todd C. McDevitt, Ranjan Sen, Job Dekker, James Taylor, Victor G. Corces Architectural protein subclasses shape the 3-D chromatin interactome at different length scales. Cell. 153 (6) 2013, 1281-1295.
6. Changying Guo*, Tatiana Gerasimova*, Haiping Hao, Irina Ivanova, Tirtha Chakraborty, Roza Selimyan, Eugene M. Oltz, Ranjan Sen. Two forms of loops generate the chromatin conformation of the immunoglobulin heavy chain gene locus. Cell. 147 (2), 2011, 332-343. (* shared first-author)