个人简历

郭小可，副教授，药物化学专业硕士生导师。2009年7月毕业于中国药科大学基础药学理科基地班专业获理学学士学位，本科毕业后免推为中国药科大学药物化学专业硕博连读研究生，2014年6月获理学博士学位，同年留校任教于药学院药物化学系任教学助理。

研究领域

①心肌钾离子通道阻滞剂的合理设计、合成与成药性评价研究，目前已推进2个候选化合物进入临床前评价阶段；②组蛋白甲基转移酶相关小分子调控剂的设计、合成、作用机制及成药性研究

近期论文

1.Dong-Dong Li, Wei-Lin Chen, Zhi-Hui Wang, Yi-Yue Xie, Xiao-Li Xu, Zheng-Yu Jiang, Xiao-Jin Zhang, Qi-Dong You*, Xiao-Ke Guo*, High-affinity small molecular blockers of mixed lineage leukemia 1 (MLL1)-WDR5 interaction inhibit MLL1 complex H3K4 methyltransferase activity, Eur. J. Med. Chem., 2016, 124, 480-489.
2.Dong-Dong Li, Zhi-Hui Wang, Wei-Lin Chen, Yi-Yue Xie, Qi-Dong You*, Xiao-Ke Guo*, Structure-based design of ester compounds to inhibit MLL complex catalytic activity by targeting mixed lineage leukemia 1 (MLL1)-WDR5 interaction, Bioorg. Med. Chem., 2016, 24, 6109-6118.
3.Wei-Lin Chen, Zhi-Hui Wang, Tao-Tao Feng, Dong-Dong Li, Chu-Hui Wang, Xiao-Li Xu, Xiao-Jin Zhang, Qi-Dong You*, Xiao-Ke Guo*, Discovery, design and synthesis of 6H-anthra[1,9-cd]isoxazol-6-one scaffold as G9a inhibitor through a combination of shape-based virtual screening and structure-based molecular modification, Bioorg. Med. Chem., 2016, 24, 6102-6108
4.Xiao-Ke Guo, Wei-Lin Chen, Hao-Peng Sun*, Qi-Dong You*, Kv1.5 Inhibitors for Treatment of Atrial Fibrillation: A Tradeoff between Selectivity and Non-selectivity, Curr. Top. Med. Chem., 2016, 16, 1843-1854.
5.Tao-Tao Feng, Dong-Dong Li, Hai Wang, Jian Zhuang, Fang Liu, Qichao Bao, Yonghua Lei, Wei-Lin Chen, Xiao-Jin Zhan, Xiao-Li Xu, Hao-Peng Sun, Qi-Dong You*, Xiao-Ke Guo*, Novel 5-carboxy-8-HQ based histone demethylase JMJD2A inhibitors: Introduction of an additional carboxyl group at the C-2 position of quinoline, Eur. J. Med. Chem., 2015, 105, 145-155.
6.Tao-Tao Feng, Wei-Lin Chen, Dong-Dong Li, Hong-Zhi Lin, Fang Liu, Qichao Bao, Yong-Hua Lei, Xiao-Jin Zhang, Xiao-Li Xu, Xiao-Ke Guo*, Qidong You*, Haopeng Sun*, Identification of novel JMJD2A inhibitor scaffold using shape and electrostatic similarity search combined with docking method and MM-GBSA approach, RSC Adv., 2015, 5, 82936-82946.
7.Xiao-Ke Guo, Xiang-Lei Ma, Qian Yang, Jing Xu, Lu Huang, Jian-Min Jia, Jiao-Jiao Shan, Li Liu, Wei-Lin Chen, Hong-Xi Chu, Jin-Lian Wei, Xiao-Jin Zhang, Hao-Peng Sun*, Yi-Qun Tang*, Qi-Dong You*, Discovery of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors (part I). Eur J Med Chem, 2014, 81, 89-94.
8.Xiao-Ke Guo, Hao-Peng Sun*, Lv-Pei Du, Lu Huang, Jing Xu, Ying-Ying Zhu, Peng Yu, Xiao-Jin Zhang, Yi-Qun Tang* and Qi-Dong You*, Discovery of Aroyl Piperazine Derivatives as IKr & IKs Dual Inhibitors for Cardiac Arrhythmia Treatment, Med. Chem., 2014, 10, 497-505.